New hope for Crohn's? experimental antibody BCD-261 enters Mid-Stage trial

NCT ID NCT07078994

Recruiting now Disease control Sponsor: Biocad Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a new drug called BCD-261 in 204 adults with moderate to severe active Crohn's disease who haven't improved with standard treatments. Participants receive either a low, medium, or high dose of BCD-261 or a placebo by injection. The goal is to see if the drug can reduce symptoms and heal the gut lining.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BCD-261 (anti-TL1A monoclonal antibody)
What this could lead to: If successful, this could lead to a new treatment option for people with moderate to severe Crohn's disease who haven't responded well to other therapies.
What could go wrong: This is an early Phase 2 trial, so it's not yet proven to work. The drug may not be more effective than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE (CD)

Contacts and locations

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Locations

"South Ural State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Chelyabinsk, 454092, Russia
Branch of the LLC "Hadassah Medical LTD"
RECRUITING

Moscow, 121205, Russia

Contact Email: •••••@•••••
Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency
RECRUITING

Krasnoyarsk, 60037, Russia
Federal State Educational Institution of Higher Education "First Saint Petersburg State Medical University named after Academician I.P. Pavlov" of the Ministry of Health of the Russian Federation
RECRUITING

Saint Petersburg, 197022, Russia
Federal State Educational Institution of Higher Education "North-West State Medical University named after I.I. Mechnikov" of the Ministry of Health of the Russian Federation
RECRUITING

Saint Petersburg, 191015, Russia
Federal State Educational Institution of Higher Education "Rostov State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Rostov-on-Don, Rostov Oblast, 344022, Russia
Federal State Educational Institution of Higher Education "Rostov State Medical University" of the Ministry of Health of the Russian Federation
RECRUITING

Rostov-on-Don, Rostov Oblast, 344022, Russia
LLC "Research Center Eco-Safety"
RECRUITING

Saint Petersburg, Sankt-Peterburg, 196143, Russia
LLC Medical Center "ASTRA"
RECRUITING

Barnaul, Altayskiy Kray, 656049, Russia

Contact Email: •••••@•••••
Llc "Novosibirsk Gastrocenter"
RECRUITING

Novosibirsk, Novosibirsk Oblast, 630007, Russia

Contact Email: •••••@•••••
Llc "Olla-Med"
RECRUITING

Moscow, 105554, Russia

Contact Email: •••••@•••••
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow City Health Department
RECRUITING

Moscow, 111123, Russia

Contact Email: •••••@•••••
Regional State Healthcare Institution "Regional Clinical Hospital
RECRUITING

Krasnoyarsk, 660022, Russia
Republican Clinical Hospital named after G.G. Kuvatov
RECRUITING

Ufa, Bashkortostan Republic, 450005, Russia
Saint Petersburg State Healthcare Institution "City Hospital of the Holy Martyr Elizabeth"
RECRUITING

Saint Petersburg, 195257, Russia
State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan"
RECRUITING

Kazan', Tatarstan Republic, 420064, Russia
State Healthcare Institution "Primorsky Regional Clinical Hospital No. 1"
RECRUITING

Vladivostok, 690091, Russia
State Healthcare Institution Ulyanovsk Regional Clinical Hospital
RECRUITING

Ulyanovsk, 432063, Russia

Contact Email: •••••@•••••
State Healthcare Institution of the City of Moscow "V.M. Buyanov City Clinical Hospital of the Moscow City Healthcare Department"
RECRUITING

Moscow, 115516, Russia
State Institution of Healthcare of the Moscow Region "Moscow Regional Research Clinical Institute named after M.F. Vladimirsky"
RECRUITING

Moscow, Moscow, 129110, Russia

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