New pill could tame Crohn's Flare-Ups

NCT ID NCT06456593

Recruiting now Disease control Sponsor: Abivax S.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental oral drug called obefazimod in 212 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants receive either obefazimod or a placebo daily for 12 weeks (induction), then up to 40 more weeks (maintenance), followed by a 48-week extension. The goal is to see if the drug reduces inflammation and symptoms better than placebo, and to check its safety over the long term.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: obefazimod (a once-daily oral drug)
What this could lead to: If successful, obefazimod could offer a new oral treatment option to reduce inflammation and improve symptoms in people with moderate-to-severe Crohn's disease.
What could go wrong: This is a mid-stage (Phase 2b) trial with only 212 participants, so results may not confirm benefit. The drug may cause side effects or fail to outperform placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATELY TO SEVERELY ACTIVE CROHN DISEASE

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

ALLMEDICA sp. z o. o.
RECRUITING

Nowy Targ, Poland
AMICARE spółka z ograniczoną odpowiedzialnością spółka komandytowa
RECRUITING

Lodz, Poland
AZ Maria Middelares
RECRUITING

Ghent, Belgium
Advanced Research Institute, Inc.
RECRUITING

New Port Richey, Florida, 34653, United States
Amsterdam UMC, Locatie AMC
RECRUITING

Amsterdam, Netherlands
Auzmer Research
RECRUITING

Lakeland, Florida, 33813, United States
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
NOT_YET_RECRUITING

Bologna, Italy
Azienda Ospedaliera Universitaria Renato Dulbecco di Catanzaro
NOT_YET_RECRUITING

Catanzaro, Italy
Baylor University Hospital
RECRUITING

Dallas, Texas, 75246, United States
Bekes Varmegyei Kozponti Korhaz
RECRUITING

Békéscsaba, Hungary
Bernhoven Uden
NOT_YET_RECRUITING

Uden, Netherlands
CHU Amiens
RECRUITING

Amiens, France
CHU Besançon - Hôpital Jean Minjoz
NOT_YET_RECRUITING

Besançon, France
CHU Bordeaux - Hôpital Haut-Lévêque
RECRUITING

Pessac, France
CHU Clermont Ferrand - Hopital d'Estaing
RECRUITING

Clermont-Ferrand, France
CHU Dijon - Hôpital Bocage Central
NOT_YET_RECRUITING

Dijon, France
CHU Lille - Hôpital Claude Huriez
NOT_YET_RECRUITING

Lille, France
CHU Nantes - Hôtel Dieu
NOT_YET_RECRUITING

Nantes, France
CHU Nice - Hôpital de l'Archet 2
NOT_YET_RECRUITING

Nice, France
CHU Saint Etienne - Hôpital Nord
NOT_YET_RECRUITING

Saint-Etienne, France
CHU UCL Namur
RECRUITING

Yvoir, Belgium
CHU de Grenoble - Hôpital Michallon
NOT_YET_RECRUITING

Grenoble, France
Central Texas Clinical Research, LLC
NOT_YET_RECRUITING

Austin, Texas, 78705, United States
Centre Hospitalier Départemental Vendée - Les Oudairies
NOT_YET_RECRUITING

La Roche-sur-Yon, France
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, France
Centre Wallonie Picarde
NOT_YET_RECRUITING

Tournai, Belgium
Centro Medico Teknon
RECRUITING

Barcelona, Spain
Centrum Medyczne Medis
RECRUITING

Bydgoszcz, Poland
Centrum Medyczne Plejady
RECRUITING

Krakow, Poland
Centrum Zdrowia MDM
RECRUITING

Warsaw, Poland
Charite-Campus Benjamin Franklin Medizin.Klin.I
NOT_YET_RECRUITING

Berlin, Germany
Clinfan Szolgaltato Kft.
NOT_YET_RECRUITING

Szekszárd, Hungary
Clinica Gaias - Santiago
RECRUITING

Santiago de Compostela, Spain
Clinical Research Of Brandon, LLC
RECRUITING

Brandon, Florida, 33511, United States
Cliniq s.r.o.
RECRUITING

Bratislava, Slovakia
DC-MED
RECRUITING

Swidnica, Poland
Dartmouth-Hitchcock Medical Center
NOT_YET_RECRUITING

Lebanon, New Hampshire, 03756, United States
ETG Zamosc
NOT_YET_RECRUITING

Zamość, Poland
ETZ Elisabeth
RECRUITING

Tilburg, Netherlands
Endomed, s.r.o.
RECRUITING

Košice, Slovakia
Fakultna nemocnica s poliklinikou F.D. Roosevelta
RECRUITING

Banská Bystrica, Slovakia
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
RECRUITING

Székesfehérvár, Hungary
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, Italy
Frontier Clinical Research, LLC
RECRUITING

Uniontown, Pennsylvania, 15401, United States
GCP Clinical Research, LLC
RECRUITING

Tampa, Florida, 33609, United States
GI Alliance
RECRUITING

Cedar Park, Texas, 78613, United States
GI Alliance - Garland
NOT_YET_RECRUITING

Garland, Texas, 75044, United States
GI Alliance - Gurnee
NOT_YET_RECRUITING

Mansfield, Texas, 76063, United States
GI Alliance -Gurnee
RECRUITING

Sun City, Arizona, 85351, United States
Gabinet Lekarski Bartosz Korczowski
NOT_YET_RECRUITING

Rzeszów, Poland
Gastro I, s.r.o.
RECRUITING

Prešov, Slovakia
Gastroenterology Consultants of Southwest Virginia.
RECRUITING

Roanoke, Virginia, 24014, United States
Gyongyosi Bugat Pal Korhaz
NOT_YET_RECRUITING

Gyöngyös, Hungary
Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen
RECRUITING

Hamburg, Germany
Henry Ford Columbus Center
RECRUITING

Detroit, Michigan, 48202, United States
Hepato-Gastroenterologie HK s.r.o.
NOT_YET_RECRUITING

Hradec Králové, Czechia
Hoag Hospital
NOT_YET_RECRUITING

Irvine, California, 92618, United States
Hopital Rangueil
RECRUITING

Toulouse, France
Hopital Saint Eloi
RECRUITING

Montpellier, France
Hopital Universitaire de Bruxelles - Hopital Erasme
RECRUITING

Brussels, Belgium
Hospital Clinico Universitario de Valencia
NOT_YET_RECRUITING

Valencia, Spain
Hospital General Juan Ramon Jimenez
RECRUITING

Huelva, Spain
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING

Córdoba, Spain
Hospital Universitario Virgen del Rocio
NOT_YET_RECRUITING

Seville, Spain
Hospital Universitario de Fuenlabrada
NOT_YET_RECRUITING

Fuenlabrada, Spain
Hospital Universitario de Gran Canaria Dr. Negrin
RECRUITING

Las Palmas de Gran Canaria, Spain
Houston Methodist Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Hôpital Bicêtre
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, France
Hôpital Henri Mondor
RECRUITING

Créteil, France
Hôpital Nord - CHU Marseille
NOT_YET_RECRUITING

Marseille, France
Hôpital de Brabois
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, France
IMC Gulf Coast Gastroenterology, PC
NOT_YET_RECRUITING

Fairhope, Alabama, 36532, United States
IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, Italy
ISCARE a.s.
NOT_YET_RECRUITING

Prague, Czechia
Inquest Clinical Research
NOT_YET_RECRUITING

Baytown, Texas, 77521, United States
Institut des MICI
RECRUITING

Neuilly-sur-Seine, France
Istituto Clinico Humanitas
RECRUITING

Rozzano, Italy
KM Management spol. s r.o.
RECRUITING

Nitra, Slovakia
Kiepury Clinic MAŁGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POŁOŻNICZA
RECRUITING

Sosnowiec, Poland
Krankenhaus Waldfriede e. V.
RECRUITING

Berlin, Germany
LMU - Campus Grosshadern
NOT_YET_RECRUITING

München, Germany
Lucida Clinical Trials, LLC
RECRUITING

New Bedford, Massachusetts, 02740, United States
Maastricht University Medical Center
NOT_YET_RECRUITING

Maastricht, Netherlands
Medical Network Spolka z o.o
RECRUITING

Warsaw, Poland
Medizinische Hochschule Hannover
RECRUITING

Hanover, Germany
Melita Medical Sp. Z O. O.
RECRUITING

Wroclaw, Poland
Mz Badania Slowik Zymla Sp J
RECRUITING

Knurów, Poland
NSZOZ Termedica - Centrum Badan Klinicznych
NOT_YET_RECRUITING

Poznan, Poland
NZOZ Centrum Medyczne KERmed
NOT_YET_RECRUITING

Bydgoszcz, Poland
NZOZ VIVAMED Jadwiga Miecz
RECRUITING

Warsaw, Poland
Nemocnice Slany
RECRUITING

Slaný, Czechia
Northwestern University
RECRUITING

Evanston, Illinois, 60208, United States
Novel Research, LLC
RECRUITING

Bellaire, Texas, 77401, United States
OSU Inflammatory Bowel Disease Center
NOT_YET_RECRUITING

Hilliard, Ohio, 43026, United States
Obudai Egeszsegugyi Centrum Kft.
NOT_YET_RECRUITING

Budapest, Hungary
Orlando Health, Inc.
RECRUITING

Orlando, Florida, 32806, United States
Ospedale Sacro Cuore Don Calabria
NOT_YET_RECRUITING

Negrar, Italy
Ospedale San Raffaele
RECRUITING

Milan, Italy
Pannonia Maganorvosi Centrum
RECRUITING

Budapest, Hungary
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Penta hospitals SK, a.s.
RECRUITING

Rimavská Sobota, Slovakia
PreventaMed s.r.o.
RECRUITING

Olomouc, Czechia
Radboud UMC
NOT_YET_RECRUITING

Nijmegen, Netherlands
Rapid City Medical Center, LLC
RECRUITING

Rapid City, South Dakota, 57701, United States
Research Associates of South Florida, LLC
RECRUITING

Miami, Florida, 33134, United States
Richmond VA Medical Center
NOT_YET_RECRUITING

Richmond, Virginia, 23249, United States
S.C Delta Health Care S.R.L
RECRUITING

Bucharest, Romania
S.C Pelican Impex S.R.L
NOT_YET_RECRUITING

Oradea, Romania
SC Centrul Medical Medicum SRL, Specialitatea Gastroenterologie
RECRUITING

Bucharest, Romania
SOLUMED Centrum Medyczne
RECRUITING

Poznan, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
RECRUITING

Łęczna, Poland
Santa Sp. z o.o. Sp. K Polimedica PTG Kielce
NOT_YET_RECRUITING

Kielce, Poland
Sarkis Clinical Trials - Parent
RECRUITING

Ocala, Florida, 34474, United States
Scottsdale Gastroenterology Specialists
NOT_YET_RECRUITING

Scottsdale, Arizona, 85260, United States
Semmelweis Egyetem
RECRUITING

Budapest, Hungary
Semmelweis Egyetem
NOT_YET_RECRUITING

Budapest, Hungary
Southern Star Research Institute, LLC
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Spitalul Clinic Colentina
NOT_YET_RECRUITING

Bucharest, Romania
St. Marienkrankenhaus
RECRUITING

Ludwigshafen, Germany
SurGal Clinic s.r.o.
RECRUITING

Brno, Czechia
Susquehanna Research Group, LLC
NOT_YET_RECRUITING

Harrisburg, Pennsylvania, 17110, United States
Texas Digestive Specialists
RECRUITING

Harlingen, Texas, 78550, United States
Theia Clinical Research Centers, LLC
RECRUITING

Temple Terrace, Florida, 33617, United States
Trialmed CRS
NOT_YET_RECRUITING

Piotrkow Trybunalski, Poland
Twoja Przychodnia Opolskie Centrum Medyczne
RECRUITING

Opole, Poland
Twoja Przychodnia PCM
RECRUITING

Późna, Poland
Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
RECRUITING

Szczecin, Poland
Tyler Research Institute, LLC
RECRUITING

Tyler, Texas, 75701, United States
UPMC
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UZ Leuven
RECRUITING

Leuven, Belgium
United Medical Doctors
RECRUITING

Murrieta, California, 92563, United States
Universitaetsklinikum Brandenburg an der Havel
NOT_YET_RECRUITING

Brandenburg an der Havel, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, Germany
Universitaetsklinikum Frankfurt Goethe-Universitaet
NOT_YET_RECRUITING

Frankfurt am Main, Germany
Universitaetsklinikum Heidelberg
NOT_YET_RECRUITING

Heidelberg, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Kiel
RECRUITING

Kiel, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, Germany
Universitair Ziekenhuis Gent
NOT_YET_RECRUITING

Ghent, Belgium
University of Iowa Health Care
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
University of Massachusetts, Worcester
NOT_YET_RECRUITING

Worcester, Massachusetts, 01655, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Washington
NOT_YET_RECRUITING

Seattle, Washington, 98195, United States
Università Campus Bio-Medico di Roma
RECRUITING

Roma, Italy
Valahia Medical SRL
RECRUITING

Ploieşti, Romania
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37212, United States
Vojenska nemocnice Brno
RECRUITING

Brno, Czechia
Wellness Clinical Research
NOT_YET_RECRUITING

Miami Lakes, Florida, 33016, United States
West Central Gastroenterology d/b/a Gastro Florida
RECRUITING

Clearwater, Florida, 33762, United States