New cell therapy trial aims to tame stubborn Crohn's

NCT ID NCT06721962

Recruiting now Disease control Sponsor: Tr1X, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental cell therapy called TRX103 for people with moderate to severe Crohn's disease that hasn't improved with standard treatments. About 39 adults will receive TRX103 along with a low dose of a chemotherapy drug to prepare the body. The main goal is to check safety and find the best dose, while also looking at whether it can reduce bowel inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TRX103 (a cell therapy) with low-dose cyclophosphamide conditioning
What this could lead to: If it works, this could point toward a new treatment option for people with Crohn's disease that hasn't responded to other therapies.
What could go wrong: This is an early, small trial (39 people) focused on safety. The treatment may not work or could cause serious side effects like infections or Crohn's flares.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abdominal Pain Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHNS DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Mayo Clinic Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Email: •••••@•••••
Mount Sinai Health Systems
RECRUITING

New York, New York, 10029, United States
Northwestern
RECRUITING

Chicago, Illinois, 60611, United States
University of California, Davis
RECRUITING

Sacramento, California, 95817, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Florida
RECRUITING

Gainesville, Florida, 32608, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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