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A common antibiotic may help Crohn's patients get more out of biologic therapy

NCT ID NCT05599347

Recruiting now Disease control Sponsor: Rambam Health Care Campus Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether a short course of azithromycin, taken before starting anti-TNF therapy, can reduce the body's tendency to develop antibodies against the biologic drug. Antibodies can make the treatment less effective over time. The study enrolls adults with Crohn's disease who are about to begin anti-TNF therapy and compares azithromycin to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
azithromycin pill
What this could lead to
If it works, this could point toward a simple way to make anti-TNF therapy more effective and durable for people with Crohn's disease.
What could go wrong
This is a mid-stage trial, so the approach may not prove effective. Azithromycin can cause side effects like gastrointestinal upset or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIOLOGICAL SUBSTANCE; ADVERSE EFFECT CROHN'S DISEASE RELAPSE

Contacts and locations

Locations

  • Bnei Zion

    RECRUITING

    Haifa, Israel

  • Carmel Medical Center

    RECRUITING

    Haifa, Israel

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, Israel

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, Israel

  • Rambam Health Care Campus

    RECRUITING

    Haifa, Haifa District, Israel

  • Shaare Zedek

    RECRUITING

    Jerusalem, Israel

  • Soroka University Medical Center

    RECRUITING

    Beersheba, Israel

  • Wolfson Medical Center

    RECRUITING

    Holon, Israel

  • Zvulun

    RECRUITING

    Kiryat Bialik, Israel

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