Could adding calcium to ORS stop diarrhea faster?

NCT ID NCT05814042

Completed Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a simple, affordable way to reduce the severity of diarrhea, which remains a major cause of death worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oral rehydration solution with added calcium
What this could lead to: If it works, this could lead to a better, low-cost treatment for severe diarrhea, potentially saving more lives in areas with limited resources.
What could go wrong: This is a completed Phase 2/3 trial, but results may not apply to children or other populations. Adding calcium might not improve outcomes over standard ORS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute diarrhea cholera diarrheal disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLERA DIARRHEA

Contacts and locations

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Locations

ICDDR,B Dhaka Hospital

Dhaka, 1212, Bangladesh

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