Small study tackles nasty side effect of lung drug

NCT ID NCT06200714

Completed Symptom relief Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. Researchers tracked how many patients had fewer than 3 loose stools per day. It is an observational study, meaning no new treatment was tested—just real-world data collection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nintedanib (OFEV)
What this could lead to: If successful, this could help doctors manage a common side effect of nintedanib, allowing patients to stay on their lung fibrosis treatment with less discomfort.
What could go wrong: This is a very small observational study (18 people) with no control group, so results may not apply to everyone. It only looks at diarrhea control, not whether the drug works for the lung disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIARRHOEA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diarrheal disease idiopathic pulmonary fibrosis pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIARRHOEA IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

Locations

Hospital Clínic i Provincial de Barcelona

Barcelona, 08036, Spain
Hospital Clínico San Carlos

Madrid, 28040, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital Universitari Germans Trias i Pujol

Barcelona, 08916, Spain
Hospital Universitario Virgen de las Nieves

Granada, 18014, Spain
Hospital Universitario de Cruces

Bizkaia, 48903, Spain
Hospital de La Princesa

Madrid, 28006, Spain
Hospital Álvaro Cunqueiro

Pontevedra, 36312, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.