Gut health boost? butyrate and polyphenol supplements under study

NCT ID NCT06419231

Completed Symptom relief Sponsor: Supplement Formulators, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested two dietary supplements—a butyrate formulation and a butyrate plus polyphenol formulation—against a placebo in 143 adults with frequent gut issues. The goal was to see if these supplements improve gut health, reduce gut permeability, and ease digestive symptoms. Participants took capsules daily and were monitored for changes in gut microbiome, symptoms, and other markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Butyrate and polyphenol dietary supplements
What this could lead to: If effective, these supplements could offer a natural way to improve gut health and ease digestive discomfort.
What could go wrong: This is a small, completed trial with no phase designation, so results are preliminary. Supplements are not regulated like drugs, and benefits may be modest or not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abdominal Pain constipation disorder diarrheal disease Heartburn Mucopolysaccharidosis IV

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GUT HEALTH

Contacts and locations

Locations

Life Extension Clinical Research, Inc.

Fort Lauderdale, Florida, 33304, United States

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