Gut health boost? butyrate and polyphenol supplements under study
NCT ID NCT06419231
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested two dietary supplements—a butyrate formulation and a butyrate plus polyphenol formulation—against a placebo in 143 adults with frequent gut issues. The goal was to see if these supplements improve gut health, reduce gut permeability, and ease digestive symptoms. Participants took capsules daily and were monitored for changes in gut microbiome, symptoms, and other markers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Butyrate and polyphenol dietary supplements
What this could lead to
If effective, these supplements could offer a natural way to improve gut health and ease digestive discomfort.
What could go wrong
This is a small, completed trial with no phase designation, so results are preliminary. Supplements are not regulated like drugs, and benefits may be modest or not apply to everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Life Extension Clinical Research, Inc.
Fort Lauderdale, Florida, 33304, United States