Diarrheal disease

This study tests a new vaccine (IP-QSV) designed to protect against four types of Shigella bacteria, which cause severe diarrhea. The trial will include 370 healthy adults, children, and infants in Mali. Researchers will check if the vaccine is safe and triggers a strong immune r…

This large study tests whether an oral cholera vaccine can also protect children aged 2 to 14 from infectious diarrhea caused by other germs. 6,000 healthy kids will get either the vaccine or a placebo. The goal is to see if the vaccine lowers the number of diarrhea cases, buildi…

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study looks at whether a fast PCR test on stool samples can help doctors make better treatment decisions for children with stomach symptoms like diarrhea, vomiting, or belly pain. About 526 children visiting the emergency room will be randomly assigned to get either immediat…

This study will check how useful endoscopy is for finding the cause of stomach and gut issues in 150 children from birth to 18 years old at Assiut University Children Hospital. The goal is to see how often the procedure gives a clear diagnosis and to track any risks. The results …

This study tests a device that automatically adds chlorine to community water systems in rural Nigeria, without needing electricity or daily effort. The goal is to see if it makes drinking water cleaner and reduces diarrhea, especially in children under five. About 2,655 adults a…

This trial tests whether painting pit latrines with insecticidal paint or adding larvicide to breeding sites can reduce filth fly numbers and diarrhoeal disease in refugee camps in South Sudan. Over 5,600 people will take part across three camps. The study will measure diarrhoea …

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This phase II trial tests whether giving preventive medications (loperamide for diarrhea and cetirizine for rash) can reduce common side effects of the cancer drug capivasertib when combined with fulvestrant. About 108 adults with HR+/HER2- metastatic breast cancer will participa…

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool, called MITI 001, is safe for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to restore healthy gut function and ease symptoms. Only 13 adults with specific sign…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This pilot study will test a mobile app called ADEPT among 30 village doctors in Bangladesh. The app helps doctors decide when antibiotics are truly needed for children with diarrhea. The goal is to see if using the app reduces unnecessary antibiotic prescriptions, which is a maj…

This study looks at why some breast cancer patients get diarrhea from the drug pyrotinib while others don't. Researchers will compare the gut bacteria of 60 patients who develop diarrhea with those who don't. They hope to find specific bacteria that protect against this side effe…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…