DIARRHEA

This is the first human study of a new vaccine called IVT Shigella-04, designed to prevent Shigella infections that cause severe diarrhea. Researchers will test five different dose levels in 60 healthy adults aged 18-49 to see if the vaccine is safe and triggers a protective immu…

This study is testing whether a fecal transplant from a carefully selected donor can help control symptoms of irritable bowel syndrome (IBS). It will involve 43 adults with moderate-to-severe IBS who have a specific gut protein activity. The main goal is to see if this procedure …

This study is testing whether two natural proteins from milk, lactoferrin and lysozyme, can help children who are recovering from severe diarrhea and malnutrition. The goal is to see if these daily supplements, mixed into food, can prevent future diarrhea episodes and help the ch…

This study is testing a medicine called rifaximin, given with oral rehydration fluids, to see if it helps children aged 6 to 11 recover from sudden, suspected bacterial diarrhea faster than using fluids alone. Researchers want to learn how the child's body processes the medicine …

This early-stage study is testing whether a treatment made from specific cultivated bacteria (SER-155) is safe and might help control severe diarrhea caused by cancer immunotherapy drugs. It will involve about 15 adults who are experiencing this side effect but have not yet recei…

This study is testing a program to prevent cholera outbreaks by focusing on neighborhoods where a cholera patient lives. Researchers will provide water, sanitation, and hygiene education to about 3,140 people living near cholera cases in Bangladesh. They want to see if this targe…

This study is testing if a 'stool transplant' (taking capsules containing processed stool from a healthy donor) can help cancer patients who develop severe diarrhea and colon inflammation from their immunotherapy drugs. Twenty patients with melanoma or kidney cancer will receive …

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This Mayo Clinic study is testing if adding the medication mirtazapine to a low-FODMAP diet helps people with IBS-D feel better than using the diet alone. The low-FODMAP diet avoids certain hard-to-digest carbs. Researchers want to see if the combination reduces abdominal pain, d…

This study aims to better understand a collection of bowel problems that can occur after someone has their entire colon removed. Researchers will follow 30 patients who have had this surgery, asking them about symptoms like diarrhea, urgency, and incontinence to see how common th…

This study aims to understand why some people with alpha-gal syndrome get stomach pain, diarrhea, and nausea after eating red meat. Researchers will give 30 participants pork with and without the alpha-gal sugar in a blinded test to see which one triggers symptoms. They will coll…