New drug aims to stop cancer wasting

NCT ID NCT07168226

Recruiting now Symptom relief Sponsor: MetaFines Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests a drug called ASCA101 in 135 adults with solid tumors (colorectal, ovarian, or lung cancer) who have cachexia—a condition causing severe weight loss and muscle wasting. Participants receive either ASCA101, an active control (Megace), or a placebo for 12 weeks. The main goal is to see if ASCA101 helps increase or maintain body weight compared to baseline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ASCA101
What this could lead to: If it works, this could lead to a new treatment that helps cancer patients with cachexia maintain or gain weight, improving their strength and quality of life.
What could go wrong: This is an early Phase 2 trial with only 135 participants, so results may not apply to everyone. The drug may cause side effects or fail to show meaningful weight improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cachexia colorectal cancer lung cancer neoplasm ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CACHEXIA; CANCER

Contacts and locations

Locations

Ajou University Hospital
RECRUITING

Gyeonggi-do, Suwon-si, South Korea
Chung-Ang University Gwangmyeong Hospital
RECRUITING

Gyeonggi-do, Gwangmyeong-si, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, Seongbuk-gu, South Korea
National Cancer Center
RECRUITING

Gyeonggi-do, Goyang-si, South Korea
Samsung Medical Center
RECRUITING

Seoul, Gangnam-gu, South Korea
Seoul ST. Mary's hospital
RECRUITING

Seoul, Seocho-gu, South Korea

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