LUNG CANCER

This study looks at whether adding an SGLT2 inhibitor (a diabetes drug) to standard cancer treatment can help people with both advanced lung cancer and type 2 diabetes live longer or slow their cancer's growth. About 200 adults will take either the SGLT2 inhibitor pill or other d…

This study compares two ways of doing robotic lung surgery for early-stage non-small cell lung cancer. In one method, the surgeon uses robotic tools entirely from a console. In the other, a bedside surgeon helps with handheld staplers. The goal is to see which approach costs less…

This study tests a combination of two drugs (Sac-TMT and bevacizumab) in 50 adults with a specific type of lung cancer (EGFR-mutant nonsquamous NSCLC) that has spread to the brain and stopped responding to standard targeted therapy. The goal is to see if the combo can shrink brai…

This early-phase study tests a new drug combination (HS-10504 plus other therapies) in 400 people with advanced non-small cell lung cancer that has worsened after prior treatment. The goal is to find safe and effective doses and see how well the treatment shrinks tumors. Particip…

This study tests a precise type of radiation therapy using proton beams for people with early-stage lung cancer who cannot or choose not to have surgery. About 65 participants will receive a few high-dose radiation sessions tailored to their tumor location. Researchers will track…

This study compares two types of targeted therapy pills (first-generation vs third-generation EGFR TKIs) for people with advanced lung cancer that has a rare EGFR mutation called 19delins. About 94 participants will be randomly assigned to one of the two treatments to see which o…

This study tests whether a special omega-3-enriched nutritional drink can help people with lung or colorectal cancer who are losing weight and at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The goal is …

This study will test a new device that uses freezing and radiofrequency heat to destroy small lung tumors during a bronchoscopy, right before patients have surgery to remove the cancer. The goal is to see if the procedure works well and is safe. About 20 adults with early-stage l…

This study tests a combination of two drugs, Sac-TMT and bevacizumab, in people with advanced non-squamous lung cancer whose cancer worsened after initial chemotherapy and immunotherapy. The goal is to see if this combo can shrink tumors or slow disease progression. About 31 adul…

This study tests whether community pharmacists can increase lung cancer screening rates. Eligible adults (aged 50-77 with a heavy smoking history) will be offered a blood test or a CT scan referral during a pharmacy visit. The goal is to catch lung cancer earlier and save lives.

This study aims to improve early detection of lung cancer by combining CT scans with a blood test that looks for DNA changes. Researchers will enroll 14,300 people aged 40-74 who have been diagnosed with cancer but haven't started treatment yet. The goal is to see if this combine…

This study tests whether using a special laser microscope (confocal laser endomicroscopy) along with a freezing biopsy probe can help doctors get better tissue samples from lung spots. Forty adults with lung lesions will be split into two groups: one gets the standard ultrasound-…

This study aims to see how well low-dose chest CT scans can detect lung cancer in people at high risk. It will include 20,000 adults aged 50-74 who are current or former heavy smokers. Participants will get a low-dose CT scan, and researchers will track how many cancers are found…

This study will test a new blood test that looks at RNA in platelets (a type of blood cell) using artificial intelligence to see if it can accurately detect lung cancer. Researchers will enroll 240 adults with either a new lung cancer diagnosis or a lung nodule found on imaging. …

This study looks at whether the shingles vaccine can prevent shingles and improve survival in 500 adults with lung cancer. Participants will be observed for 12 months to see who gets shingles and how long they live. The goal is to find out if this vaccine is safe and effective fo…

This study aims to see if low-dose CT scans can help find lung cancer early and reduce deaths in high-risk smokers. About 15,000 current or former heavy smokers aged 50-79 in Hong Kong will be randomly assigned to get either regular CT scans or standard care. The main goal is to …

This study tests a video-guided breathing tube for people having a second lung surgery. It aims to make tube placement easier and safer by letting doctors see inside the airway in real time. About 500 adults with lung cancer or nodules will take part. The goal is to reduce compli…

This study tests whether a combination of two anti-nausea drugs (rolapitant and palonosetron) can prevent vomiting and nausea in lung cancer patients undergoing chemoradiotherapy. About 238 adults with lung cancer will receive the drug combo and be monitored for 6 weeks. The goal…

This study tests whether a personalized exercise program is practical for people with stage II or III lung cancer before they start treatment. Twenty participants will follow the program, and researchers will track how many complete at least 80% of the sessions. The goal is to se…

This study tests whether an 8-week home exercise and breathing program before lung cancer surgery, followed by 4 weeks of rehab at home, helps patients recover faster and have fewer complications. About 84 adults with operable lung cancer will take part, using a smartphone app to…

This study looks at whether it's possible for people with stage I-III non-small cell lung cancer to do a short, supervised exercise session right before each radiation treatment. About 30 participants will ride a stationary bike for 20 minutes at a personalized intensity. The mai…

This study tests a program to help long-term lung cancer survivors feel more supported and improve their quality of life. Thirty survivors will be randomly assigned to either the support program or a comparison group. The program uses techniques from cognitive behavioral therapy …

This pilot study tests whether gentle osteopathic manipulations (a type of hands-on bodywork) can stimulate the vagus nerve in people with stage 4 lung cancer. The goal is to see if these safe, non-invasive techniques can improve heart rate variability, which is linked to better …

This study tests whether doing special breathing exercises (inspiratory and expiratory muscle training) before lung cancer surgery can reduce lung problems after the operation. About 70 adults scheduled for lung cancer surgery will be randomly assigned to standard physical therap…

This study tests a program called FOCUS, delivered through a smartphone app and telemedicine, to help people with advanced cancer manage common symptoms like trouble sleeping, worry, sadness, and fatigue. The goal is to improve quality of life and make these skills accessible to …

This study aims to see if a simple, non-drug approach can help people with lung cancer feel better during chemotherapy. Researchers will teach 60 patients special mindfulness breathing exercises over eight weeks to see if it reduces symptoms like shortness of breath and fatigue, …

This study tests whether 3D models made from a standard CT scan (no contrast dye) are as accurate as contrast-enhanced CT scans for planning lung cancer surgery. About 50 adults with early-stage lung cancer will have both scans, and doctors will compare the 3D model's predictions…

This study looks at how breathing in wildfire smoke can lead to long-term lung problems like asthma, COPD, and lung cancer. Researchers will safely expose 24 healthy adults to different levels of smoke in a controlled setting. The goal is to learn who is most at risk and what bio…

This study aims to see if using prediction models to identify Veterans who would benefit most from lung cancer screening can increase the number of people who get screened. Lung cancer is the top cancer killer of Veterans, often found too late for a cure. The trial will enroll ab…

This study will observe about 477 Brazilian smokers aged 50-80 to see how well lung cancer screening works in a region where other lung diseases are common. The goal is to find out how often screening gives false alarms, which can lead to extra tests and worry. Researchers hope t…

This study tests whether artificial intelligence (AI) can help doctors read low-dose CT scans more accurately for lung cancer screening. About 1120 adults at risk for lung cancer will be randomly assigned to have their scans read with or without AI assistance. The goal is to see …

This study tests whether using a chat-based mobile app (Zalo) can help more people complete recommended follow-up tests after an AI-powered chest X-ray finds possible signs of lung cancer or tuberculosis. About 2,692 adults aged 40-62 in Vietnam will be split into two groups: one…

This study will enroll over 3,200 adults in Delhi, India, to understand how air pollution, along with smoking and genetics, increases the risk of lung cancer. Researchers will track participants and analyze exposure to fine particulate matter (PM2.5) to identify who is most vulne…

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study looks at whether community health workers can help more people get lung cancer screening and quit smoking. About 80 adults aged 50-80 who are at risk for lung cancer will take part. The goal is to see if this approach is practical and acceptable, paving the way for a l…

This early-stage study tests whether inhaling the cancer drug afatinib works as well as taking it by mouth. It involves 24 healthy adult smokers who will receive both forms in separate sessions. The goal is to measure drug levels in the blood and lungs, and check for side effects…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …

This early-stage study looks at how the body processes anecatibin fumarate, a potential lung cancer treatment, in people with different levels of liver function. Researchers will compare 24 adults with either impaired or normal liver function to see how the drug moves through the…

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for outlining tumors and healthy organs before radiation therapy. About 80 adults with brain, bone, head/neck, or lung cancer will get both scans, and doctors will compare how accurately the…