LUNG CANCER

This study compares two ways to perform robotic surgery for early-stage lung cancer. One method is fully robotic, where the surgeon controls everything from a console. The other method involves a surgeon assisting at the bedside with handheld tools. Researchers want to see which …

This study is testing a home-based exercise and breathing program for people scheduled for lung cancer surgery. The program lasts 8 weeks before surgery and 4 weeks after, guided by a mobile app, with the goal of improving patients' fitness before the operation and speeding up re…

This study is testing a medical device called the HybridTherm® system during a lung procedure called bronchoscopy. The device uses a combination of cold and radiofrequency energy to destroy small lung cancer tumors. Researchers want to see if using this device is safe and practic…

This study is testing a treatment plan for adults with a specific type of advanced, inoperable lung cancer who are not candidates for or refuse chemotherapy. The plan involves taking a targeted pill called osimertinib for about 12 weeks, followed by radiation therapy, and then co…

This study is testing a new video-guided breathing tube designed to make anesthesia safer for patients needing a second lung surgery. It aims to help doctors place the tube correctly on the first try and monitor the airway during the operation. The research will involve 500 adult…

This study is testing whether a special nutritional drink with omega-3 fatty acids (like those in fish oil) can help people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will be split into two groups: one gets the omega-3 drink pl…

This study in Vietnam tests if using a popular chat app (Zalo) to talk with doctors helps people actually get the follow-up tests they need after an artificial intelligence (AI) system finds something unusual on their routine chest X-ray. It focuses on adults at risk for lung can…

This study aims to find out which type of targeted drug works better as the first treatment for advanced lung cancer with a specific, less common genetic change called an EGFR '19delins' mutation. It will compare older 'first-generation' drugs with newer 'third-generation' drugs.…

This study is testing if adding a common type of diabetes pill (called an SGLT2 inhibitor) to standard cancer treatment can help people who have both advanced lung cancer and type 2 diabetes. Researchers want to see if these pills can help patients live longer or slow down the ca…

This early-stage study is testing a new combination therapy called HS-10504 for people with advanced non-small cell lung cancer that has continued to grow despite previous treatments. The main goals are to find the safest and most effective dose and to see how well the body handl…

This study is testing a new two-drug combination for people with a specific type of advanced lung cancer that has worsened after their first treatment. It aims to see if the treatment can shrink tumors and control the disease. The trial will enroll about 31 patients to closely mo…

This study is testing a specialized, high-dose form of radiation therapy using proton beams for people with early-stage lung cancer who are not candidates for surgery or who refuse it. The goal is to see how well this treatment controls the cancer, how long patients live without …

This study is testing whether a drug called axelopran can help control advanced cancers of the lung, breast, pancreas, and prostate in patients who are taking opioid pain medication. Researchers want to see if the drug can slow tumor growth, improve bowel function, and reduce inf…

This study is testing whether a new two-drug combination can help control advanced lung cancer that has spread to the brain after other targeted treatments have stopped working. It will enroll 50 patients with a specific genetic type of lung cancer to see if the treatment shrinks…

This study is testing if a type of CT scan called Dual-Energy CT (DECT) can work as well as MRI scans for planning radiation therapy. Doctors need very clear pictures to map out tumors and avoid damaging healthy organs during radiation. The study will enroll 80 patients with canc…

This study is testing whether artificial intelligence (AI) software can help doctors read lung cancer screening scans more accurately and efficiently. Over 1,100 participants will be randomly assigned to have their low-dose CT scans read either with the help of AI software or by …

This study is testing a new blood test that uses artificial intelligence to analyze RNA from platelets to detect lung cancer. Researchers will enroll 240 people, including those with lung nodules or newly diagnosed lung cancer, to see if this test can accurately tell cancerous fr…

This study aims to develop a better method for finding lung cancer early by combining two tests: a low-dose CT scan and a new blood test that looks for cancer signals. It will enroll 14,300 people, including those with and without cancer, to see if using both tests together is mo…

This study is testing whether using a special high-magnification camera (confocal laser endomicroscopy) during a lung biopsy can make the procedure safer and more accurate. Researchers will compare this new method to the standard technique in 40 patients with suspicious lung spot…

This study is testing a new computer tool that creates a 3D model of a patient's lungs before lung cancer surgery. Doctors will use this model to perform a 'virtual surgery' to predict how well the patient's lungs will work after the real operation. The goal is to give surgeons a…

This study offers free, low-dose chest CT scans to 1,200 California firefighters to check for early signs of lung cancer and other work-related lung diseases. Firefighters face higher cancer risks from smoke and chemical exposure, but current screening rules often overlook this j…

This study is testing whether 3D models created from a standard CT scan (without contrast dye) are as accurate as models from a contrast CT scan for planning a precise type of lung cancer surgery. It will involve 50 adults with early-stage lung cancer who are eligible for minimal…

This study aims to see if getting the shingles vaccine can help prevent shingles in people with lung cancer. Researchers will follow 500 adult lung cancer patients who have never had the vaccine to check if they get shingles over a year. They will also track the patients' surviva…

This study aims to find out if regular low-dose CT scans can help prevent deaths from lung cancer in people at high risk. It will enroll 15,000 Chinese adults in Hong Kong aged 50-79 who are current or former heavy smokers. Half will receive three scans over several years, while …

This study aims to see if specially trained community health workers can help more people get screened for lung cancer. The workers will reach out to eligible patients, help them understand screening, offer smoking cessation support, and assist with scheduling. The goal is to fin…

This study aims to see if a simple program can get more people screened for lung cancer. It will work with 300 eligible patients in an emergency department who are current or former heavy smokers. Researchers will test if providing a direct referral to a screening program plus se…

This large VA study aims to increase lung cancer screening among eligible Veterans. It will test whether using personalized risk prediction tools, alongside support for doctors and patients, can get more people screened compared to current standard guidelines. The goal is to find…

This study is testing whether a personalized exercise program is practical and acceptable for people with stage II-III lung cancer. It will involve about 20 participants who will follow the exercise plan before, during, and after their cancer treatment. The main goal is to see if…

This study is testing a combination injection to prevent nausea and vomiting in lung cancer patients who are receiving chemotherapy and radiation at the same time. It will compare two different anti-nausea drug combinations to see which one works better. The goal is to improve co…

This study is testing a web-based tool called CARE that helps cancer patients understand treatment costs, health insurance, and find financial resources. Researchers will enroll 430 patients with gynecologic, prostate, lung, or colorectal cancer to see if using the tool reduces f…

This pilot study explores whether gentle osteopathic techniques can help lung cancer patients during chemotherapy. Researchers will measure if these hands-on treatments improve heart rate variability—a sign of better nervous system balance—and reduce anxiety. The study involves 8…

This study is testing a phone app called FOCUS that teaches coping skills to help people with advanced cancer manage common symptoms like fatigue, anxiety, depression, and sleep problems. It aims to make this support more accessible to patients living in rural areas who may have …

This study aims to understand how patients feel and what they believe after an artificial intelligence (AI) tool tells them their personal risk of developing lung cancer in the next three years. Researchers at the University of Illinois will enroll up to 400 current or former hea…

This study aims to understand how cancer and its treatments affect patients' enjoyment of food and eating. Researchers will survey 180 adults with various cancers to identify which factors most harm food-related quality of life. The goal is to create a model to predict which pati…

This study aims to understand why strength training improves the health of people with various cancers. Researchers will enroll 150 patients with lung, breast, colon, blood, or lymph node cancers. Half will do supervised strength training twice a week for 12 weeks, while the othe…

This study aims to understand the real-world results of lung cancer screening in Brazil. Researchers will observe about 477 high-risk smokers to see how often scans incorrectly suggest cancer, leading to unnecessary follow-up tests. The goal is to learn if screening works as well…

This early-stage study aims to see if inhaling the cancer drug afatinib works similarly to taking it as a pill. It will involve 24 healthy adult smokers who will try both the inhaled and oral versions. Researchers will measure how much of the drug gets into the body and lungs to …