LUNG CANCER

This study is testing whether an investigational drug called QBS72S can shrink tumors that have spread to the brain from breast or lung cancer. It involves 21 adults with advanced cancer that has spread to the central nervous system. Researchers will measure how well the drug wor…

This study is testing how well the drug brigatinib works for people with advanced non-small cell lung cancer that has a specific genetic change (ALK+). Researchers will also explore if simple blood tests (liquid biopsies) can help track how the cancer responds to treatment over t…

This study is testing whether a drug called ado-trastuzumab emtansine can help control advanced solid tumors that have specific abnormalities in the HER2 gene. The trial is enrolling adults with cancers like lung, bladder, and urinary tract cancers that have these genetic feature…

This study is checking how safe it is to combine two standard treatments—radiation therapy and immunotherapy drugs—for people with advanced lung cancer that has spread. Researchers are watching 12 patients to see what side effects occur and how the treatment affects their quality…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy after lung cancer surgery can better prevent the cancer from returning. It focuses on patients who have signs of remaining cancer cells in their blood after surgery, which indicates high…

This study tests whether using a patient's own blood as a patch can help seal air leaks that sometimes occur after lung cancer surgery. The trial involves 120 patients who still have an air leak three days after their operation. Researchers will compare outcomes between patients …

This study is testing whether adding an older drug called DFMO to the immunotherapy pembrolizumab can help control advanced lung cancer in people whose tumors have a specific genetic change (STK11 mutation). The first part finds the safest dose, and the second part checks if the …

This program provided access to an experimental cancer treatment called NanoPac for patients with advanced pancreatic, prostate, or lung cancer who couldn't join regular clinical trials. It was designed to offer treatment options when standard trials weren't available. The progra…

This study is testing whether adding an immunotherapy drug called durvalumab to a precise form of radiation therapy (SBRT) works better than radiation alone for early-stage lung cancer. It is for patients with a higher risk of their cancer returning who are not candidates for sur…

This is the first human study of an experimental oral medication called HBI-2438 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. The study …

This trial is testing if adding chest radiation therapy to a maintenance immunotherapy drug (durvalumab) can better control advanced small cell lung cancer. Patients first receive standard chemotherapy combined with durvalumab. If the cancer responds or stays stable, they then re…

This study is testing whether combining two drugs, savolitinib and durvalumab, can help control advanced lung cancer in Chinese patients whose tumors have a specific genetic change called a MET alteration. The goal is to see if this combination can slow or stop the cancer's growt…

This early-stage study is testing whether adding a new drug called amivantamab to standard targeted therapies can help control advanced lung cancer that has started growing again. It will involve about 12 adults whose cancer has specific genetic changes and has become resistant t…

This early-stage study is testing the safety of a new two-part treatment for advanced non-small cell lung cancer that has stopped responding to standard immunotherapy. The treatment combines a modified virus designed to attack tumors with an existing immunotherapy drug (pembroliz…

This study is testing a new medical device that uses microwave energy to destroy small lung tumors. Doctors guide a thin tube through the patient's airway to reach and heat up the tumor. The main goals are to see if this procedure is safe and if the device can reliably reach and …

This study is testing if a text-message chatbot named 'Penny' can help people with lung cancer remember to take their daily oral medications and manage side effects. Researchers are comparing the chatbot to usual care in 75 patients to see if it improves how consistently patients…

This study is testing whether a 3-4 week pulmonary rehabilitation program can improve lung function in lung cancer patients who currently don't qualify for surgery. The program includes supervised exercise training, education, and counseling to help patients build strength and br…

This large Phase 3 trial is comparing a new drug combination (QL1706 plus chemotherapy) against a standard treatment for patients with advanced non-small cell lung cancer that has spread and tests negative for a specific biomarker called PD-L1. The study aims to see if the new co…

This early-stage trial is testing whether adding an experimental oral drug called AZD6244 to standard chemotherapy is safe for people with advanced cancers like breast, lung, colon, and kidney cancer. The study will find the highest dose patients can tolerate and track how the bo…

This early-stage study is testing whether combining two existing cancer drugs—ceritinib and docetaxel—can help control advanced lung cancer that has stopped responding to standard chemotherapy. The trial aims to find the safest dose of this combination and see if it can shrink tu…

This study is testing whether combining two immunotherapy drugs (zimberelimab and domvanalimab) can help control advanced non-small cell lung cancer in people who haven't had prior treatment. The trial is for patients whose cancer has high levels of a specific marker called PD-L1…

This study is testing whether combining a drug called durvalumab (an immunotherapy) with radiation therapy can help control locally advanced non-small cell lung cancer. It is for patients who are not eligible for the standard treatment of chemotherapy followed by radiation, often…

This early-stage study is testing whether combining an existing arthritis drug (sarilumab) with an existing cancer immunotherapy (cemiplimab) can help control advanced non-small cell lung cancer. It is enrolling 56 adults whose cancer has specific genetic changes (EGFR or LKB1 mu…

This is a first-in-human study testing a new personalized cell therapy for people with advanced solid tumors that have not responded to standard treatments. Doctors take a patient's own tumor-fighting immune cells from a tumor sample, grow large numbers of the most potent ones in…

This study tested a new system in a lung cancer clinic to help patients quit smoking. Researchers wanted to see if staff asked patients about smoking and offered them proven help like medication or counseling. They measured success by checking if patients actually quit, using bre…

This study is testing a new drug called JDQ443, both alone and in combination with other treatments, for patients with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find safe doses and see if the treatments can shrink tumors. It…

This study is testing whether a special type of radiation guided by MRI can safely deliver higher doses to lung tumors located dangerously close to major airways or the food pipe. Up to 38 patients will receive this treatment, with the goal of finding the highest dose that does n…

This study is testing if a short, high-precision form of radiation (SBRT) can help restart the effectiveness of immunotherapy drugs in patients whose cancer has started to grow again. It involves adults with certain advanced cancers (like melanoma, lung, or bladder cancer) who ar…

This study is testing the safety of adding a new immunotherapy drug (MPDL3280A) to the standard treatment of chemotherapy and radiation for patients with non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this three-part combination is safe and ca…

This study is testing two different techniques for delivering a precise type of radiation treatment (SBRT) to lung tumors while patients hold their breath. The goal is to see which method causes fewer lung side effects and is more reliable at hitting the tumor accurately. It will…

This study is testing whether adding the targeted drug osimertinib before and after standard chemoradiation helps control stage III lung cancer that cannot be removed by surgery. It will involve about 76 adults whose cancer has specific EGFR gene changes. The goal is to see if th…

This study is testing a new, simpler way to give an existing lung cancer drug. It compares giving the drug as an under-the-skin injection versus the standard method of an IV infusion. The main goals are to see if the injection gets similar drug levels into the body and is as safe…

This study is testing if combining two existing cancer drugs, pembrolizumab and vorinostat, is safe and works better than pembrolizumab alone for people with advanced lung cancer that has spread. It will involve about 120 adults whose cancer has progressed after at least one prio…

This early-stage study is testing whether adding a short, focused course of radiation (a 'boost') to a standard immunotherapy drug (durvalumab) is safe and can help control stage III non-small cell lung cancer. The treatment is given after patients finish their initial chemo-radi…

This study allows patients who were already taking the drug ruxolitinib in a previous cancer trial to continue receiving it, along with their other cancer treatments, if they are benefiting. It's for people with pancreatic, colorectal, breast, or lung cancer who are doing well on…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This trial is testing a new treatment for advanced cancers that have spread to the lining of the chest (pleura), including mesothelioma, lung cancer, and breast cancer. Doctors collect a patient's own immune cells (T cells), genetically modify them to recognize a cancer protein c…

This study is testing whether an AI software program can help doctors prioritize which chest X-rays to look at first when checking for possible lung cancer. The goal is to get patients who need a follow-up CT scan identified faster, which could lead to quicker diagnosis and treat…

This study is testing a safe dose of a special dye and a near-infrared light to help surgeons see and remove the first lymph node that drains from a lung tumor. By finding and analyzing this 'sentinel' node more precisely, doctors hope to better detect if cancer has spread. The s…

This study is testing whether a new, less invasive method can accurately find genetic changes in early-stage lung cancer. Researchers will collect fluid from inside lung tumors during a thin-tube procedure and analyze it with advanced genetic testing. The goal is to see if this f…

This study is testing whether a new blood test called GuardantLUNAR-2 can accurately detect lung cancer in people at high risk. It will enroll 12,000 current or former heavy smokers who are already scheduled for a standard CT scan. Researchers will compare the blood test results …

This study is testing a new blood test called Lung EpiCheck to see if it can accurately detect early-stage lung cancer. It involves 5,000 current or former heavy smokers who are either getting a routine CT scan for screening or have a suspected or confirmed lung cancer diagnosis.…

This study is testing a new robotic system designed to help doctors more accurately biopsy suspicious lung nodules. It involves 132 patients with lung nodules at moderate to high risk for cancer. The goal is to see if this robotic system, combined with 3D imaging, can improve the…

This is a small, early-stage study to test a new type of imaging scan. The scan uses a special radioactive tracer that attaches to a protein (CEA) made by many cancers. The goal is to see if this new scan can find cancer spots that standard imaging tests might miss in patients wi…

This study is testing a new imaging technology called HyperSight to see if it can take clearer pictures during radiation therapy. The goal is to help doctors more accurately target cancer cells while better protecting healthy tissue. About 40 adults with head and neck, breast, lu…

This study aims to find the best way to collect tissue samples during a lung cancer biopsy to ensure there is enough material for advanced genetic testing. It will compare taking two needle passes versus three passes from suspicious lymph nodes. The study will also test if a simp…

This early-stage study is testing a new radioactive tracer called [18F]-C-SNAT4 for PET scans. The goal is to see if this tracer can safely and effectively help doctors better see and monitor lung cancer. The study will involve 20 people, including healthy volunteers and patients…

This study is testing how to best set up a national lung cancer screening program in Germany. It will enroll over 12,000 current and former smokers aged 55-79 to compare different methods of identifying high-risk people and using CT scans to find cancer early. The goal is to crea…

This study is testing simple reminder strategies to help more eligible people get their annual lung cancer screenings and any needed follow-up tests. It involves sending text message reminders to patients and electronic alerts to their doctors. The goal is to remove common barrie…

This study is testing a comprehensive prevention program for long-term smokers aged 55-75. The program combines low-dose aspirin, a quit-smoking medication, a Mediterranean-style diet, and increased physical activity, along with annual lung scans. The goal is to see if this multi…

This study is testing a new program to help more people at risk for lung cancer get screened. It uses text messages, videos, and telehealth calls to guide patients through the screening process and help them overcome common barriers like confusion or scheduling. The goal is to se…

This study is testing different reminder messages to help people who smoke or used to smoke get screened for lung cancer. Researchers want to find the most effective way to remind eligible adults aged 40-80 to get this important preventive screening. The goal is to increase scree…

This study tests a program designed to help more Hispanic patients get screened for lung cancer. It works by reminding doctors, educating patients, helping with costs, and prompting discussions during doctor visits. The goal is to see if this approach gets more eligible patients …

This study is testing two new programs to help more people get their yearly lung cancer screening scans on time. It involves nearly 1,800 Kaiser Permanente members who are at high risk for lung cancer. The programs focus on patient education and sending reminders to see if they i…

This study is testing whether it's practical to offer a smartphone app with mindfulness exercises to lung cancer patients before and after their surgery. The goal is to see if using the app helps reduce anxiety and distress related to their cancer diagnosis and treatment. The sma…

This study is testing whether a personalized mobile app with live coaching can improve quality of life for people who have had cancer. The 18-month program focuses on exercise, meditation, and diet advice. Researchers will compare the app's coaching to standard lifestyle resource…

This study aims to understand if having low muscle mass (sarcopenia) before lung cancer surgery affects how well patients recover afterward. Researchers will follow 400 elderly patients undergoing surgery to see if muscle measurements can help predict their survival, complication…

This study is testing a new technology designed to track lung tumors during radiation therapy without needing to implant physical markers near the tumor. The goal is to see if this 'markerless' tracking is accurate enough to guide radiation beams in real time. Five patients with …

This study is testing whether a new payment model that encourages better care coordination improves health outcomes and reduces costs for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who receive chemotherapy through specific Hawaii prov…

This study aims to better understand the conversations between lung cancer patients and their doctors. Researchers are observing these consultations and asking patients about their experience to see how communication quality affects patient satisfaction and well-being. The study …

This study aims to collect leftover tissue and blood samples from people with cancer who are already having surgery or a biopsy. Researchers will study these samples to better understand cancer and find new targets for future treatments. The study will enroll about 1200 adults an…

This study is testing a new system to monitor symptoms in lung cancer patients taking oral targeted therapies. Participants use a smartphone app, a Fitbit watch, and a smart pill bottle cap for up to 24 weeks. The goal is to see if this remote system works well and to gather info…

This research study aims to learn about the biological features of how chest cancers like lung cancer, thymus tumors, and mesothelioma develop and spread. Researchers will analyze blood, tumor tissue, and other fluids from about 1000 patients to look for genetic markers. The goal…

This study aims to understand if tiny plastic particles in the air we breathe end up in our lungs and if they are connected to lung cancer. Researchers are analyzing lung fluid samples from 119 patients who are already scheduled for a standard lung washing procedure. The goal is …

This study aims to understand if a patient's natural breathing pattern before surgery can help predict who might experience low oxygen levels during a specific type of lung cancer operation. Researchers will measure breathing patterns before surgery and monitor oxygen levels duri…

This study is testing a new support framework for clinics that run lung cancer screening programs. Researchers are asking staff at up to 8 clinics across the US to try this new approach and give their feedback. The goal is to see if the framework is practical, acceptable, and som…

This study aims to find better ways to detect lung cancer early in people at high risk. Researchers are following 45 current or former heavy smokers who are uninsured, collecting samples and performing regular chest scans over five years. The goal is to learn what signs might pre…

This study aims to better understand the real-world symptoms and treatment experiences of adults with certain cancers. About 100 participants with breast, lung, gastrointestinal cancer, or multiple myeloma will complete weekly digital surveys about their symptoms for at least 12 …

This study is testing a new type of MRI scan that uses a special inhaled gas to see if it can predict which lung cancer patients will develop serious lung inflammation from radiation therapy. Researchers will scan patients before, during, and after their radiation treatment to lo…

This study aims to understand if an inherited change in a gene called EGFR increases a person's risk of developing lung cancer, particularly in people who have never smoked. Researchers are recruiting people with a specific cancer mutation (T790M) and their family members to prov…

This study is testing a special type of PET scan to find areas of low oxygen inside lung cancer tumors. Low oxygen can make tumors harder to treat with radiation or chemotherapy. Researchers want to see if this scan can reliably provide this information to help guide future treat…

This study aims to gather information to design a better, more manageable care plan for people who have both cancer and COPD (a chronic lung disease). Researchers will interview 100 patients and healthcare providers to understand the challenges of managing both conditions. The go…