LUNG CANCER

This study tests a new tool that uses microwave energy to destroy small lung tumors. The tool is inserted through a tube into the lungs, avoiding the need for open surgery. The study includes 35 adults with lung nodules that are either confirmed or suspected to be cancer. The mai…

This study aimed to compare three different immunotherapy approaches (atezolizumab, nivolumab, and pembrolizumab) given before and after surgery for people with early-stage non-small-cell lung cancer. The goal was to see which approach best prevented the cancer from coming back. …

This study tests whether adding chest radiation to maintenance durvalumab can help people with extensive-stage small cell lung cancer live longer without the disease getting worse. About 46 participants will first receive standard chemo plus durvalumab, then those whose cancer re…

This early-stage trial tests a precise radiation technique for lung tumors located very close to the windpipe or food pipe. Up to 38 adults with such 'ultracentral' tumors will receive daily MRI-guided radiation that adapts to the tumor's position. The main goal is to find the hi…

This study tests whether a precise type of radiation called SBRT can restore the effectiveness of immunotherapy drugs in people with metastatic cancer that has started to grow again. About 69 adults with cancers such as melanoma, lung, bladder, kidney, or head/neck cancer will re…

This study tests a treatment for people with advanced lung cancer that has spread to the brain. It combines two immunotherapy drugs (nivolumab and ipilimumab) with a short course of chemotherapy. The goal is to see if this approach can control the brain tumors for at least 6 mont…

This study looks at whether a blood test (liquid biopsy) can help doctors see how well the drug brigatinib is working in people with a specific type of advanced lung cancer (ALK-positive NSCLC). About 33 patients will take brigatinib pills and give blood samples over time. The go…

This study tests a new drug called QL1706 combined with chemotherapy for people with advanced non-small cell lung cancer that does not have the PD-L1 protein. About 606 adults will be randomly assigned to receive either QL1706 with chemo or another drug (tislelizumab) with chemo.…

This study tests a drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors and help people live longer without the cancer getting worse. Participants must be 18 or older and in fairly…

This study tests whether adding the drug durvalumab to precise radiation therapy (SBRT) can keep early-stage non-small cell lung cancer from coming back longer than radiation alone. It involves 13 adults with stage I to IIIA disease. The main goal is to see how long participants …

This study tests a combination of two immunotherapy drugs (zimberelimab and domvanalimab) as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called PD-L1. The goal is to see if the combination can slow or stop cancer growth …

This study tests whether combining two drugs, pembrolizumab and vorinostat, can help people with advanced non-small cell lung cancer. About 120 adults with stage IV disease will receive either the combination or pembrolizumab alone. The goal is to see if the combo is safe and can…

This study tests whether combining the drug durvalumab with radiation therapy can slow down cancer growth in people with locally advanced non-small cell lung cancer. About 61 adults with stage II or III lung cancer who would normally receive chemotherapy followed by radiation are…

This early-phase study tests a combination of two drugs, ceritinib and docetaxel, in people with advanced non-small cell lung cancer that does not have certain gene changes (ALK-negative, EGFR wild-type). The main goal is to find the safest dose and see if the combination can shr…

This early-stage trial tests a new treatment for people with advanced solid tumors (like head and neck, melanoma, or lung cancer). Doctors take a patient's own immune cells from the tumor, grow them into billions, and give them back as a one-time infusion. Some cells are also mod…

This early-phase study tests a treatment called TBI-1301 for people with advanced solid tumors (like sarcoma, melanoma, or ovarian cancer) that have not responded to other therapies. The treatment uses a patient's own immune cells, which are genetically modified in a lab to bette…

This study tracks 29 adults in Taiwan with advanced lung cancer who have a specific gene change (EGFR-positive) and were treated with the oral drug dacomitinib. Researchers want to see how often people need to change their dose or stop treatment, and how long they live without th…

This study tests whether adding the drug zipalertinib to standard chemotherapy after lung cancer surgery helps prevent the cancer from returning. It is for people with early-stage (IB-IIIA) non-small cell lung cancer that has specific uncommon EGFR mutations. About 360 participan…

This phase 3 study tests a two-step approach for people with a specific type of advanced lung cancer (EGFR-mutant, stage III). First, patients take a targeted pill called almonertinib. Then, based on a sensitive blood test (MRD) and team evaluation, they may get surgery or radiat…

This early-phase study tests a new drug, BG-60366, designed to break down a faulty protein (mutant EGFR) that drives non-small cell lung cancer. About 33 adults with advanced or spreading lung cancer who have already tried other treatments will receive the drug to see if it is sa…

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find th…

This study tests whether a pulmonary rehabilitation program can improve lung function in people with lung cancer who are not healthy enough for surgery. The goal is to help more patients become eligible for lung resection. Researchers will also check how these patients recover af…

This study tested whether adding low-dose radiotherapy to standard chemotherapy and an immunotherapy drug (durvalumab) could help people with extensive-stage small cell lung cancer live longer without the disease getting worse. The trial enrolled 30 adults with advanced lung canc…

This study offers continued treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte-sponsored trial. Participants must have stable disease and be tolerat…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy after lung cancer surgery can clear tiny bits of tumor DNA from the blood. About 100 adults with early-stage non-small cell lung cancer who had surgery and still have detectable tumor DNA…

This study tests a drug called DFMO combined with the immunotherapy pembrolizumab in people with advanced non-small cell lung cancer that has a specific gene change (STK11/LKB1). The goal is to find a safe dose and see if the combination shrinks tumors. About 45 adults will take …

This study tests whether combining two drugs, savolitinib and durvalumab, can help control advanced lung cancer in people whose tumors have a change in the MET gene. About 47 adults in China with this specific type of lung cancer will receive the treatment. The main goal is to se…

This study tests a drug called ado-trastuzumab emtansine (T-DM1) in 131 adults with advanced solid tumors that have a specific change in the HER2 gene. The goal is to see how well the drug shrinks or controls the cancer. Participants must have certain HER2 mutations or amplificat…

This early-phase study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goal is to find the safest dose and check for side effects. About 44 adults who have tried other tre…

This study tests whether giving the targeted drug osimertinib before and after standard chemoradiation helps people with a specific genetic type of stage III lung cancer that cannot be removed by surgery. About 76 adults with EGFR-mutated non-small cell lung cancer will receive o…

This early-stage trial tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment combines a specially designed virus (TILT-123) that targets cancer cells with pembrolizumab, an immunotherapy drug. Th…

This study tests whether a new under-the-skin injection of the immunotherapy drug pembrolizumab works as well as the standard IV infusion for people with advanced non-small cell lung cancer. About 67 participants will receive either the shot or the IV, and researchers will measur…

This early-phase study tests a new drug, amivantamab, combined with standard targeted therapies (TKIs) in 12 adults with advanced non-small cell lung cancer that has specific gene changes (ALK, ROS1, or RET). The cancer has stopped responding to current treatments. The goal is to…

This study tests whether injecting a patient's own blood into the chest can stop air leaks that sometimes happen after lung cancer surgery. About 60 adults who still have an air leak three days after surgery will receive the blood patch. The goal is to see if it prevents prolonge…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This study tests the safety of adding an experimental drug (MPDL3280A) to standard chemotherapy and radiation for people with a type of lung cancer that cannot be removed by surgery. About 52 participants will receive the combination therapy. The main goal is to see how safe the …

This program offers expanded access to NanoPac, a cancer treatment, for people with advanced pancreatic, prostate, or lung cancer who do not qualify for current clinical trials. The goal is to provide the drug to patients who have no other good treatment options. However, this pr…

This study tests a treatment using a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells with a protein called mesothelin. It is for people with malignant pleural disease, including mesothelioma and cancers that have spread to the chest lining. …

This study tests a new drug called JDQ443, alone or with other medicines, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe and can shrink tumors. About 344 adults whose cancer has not responded to standard treatm…

This study tests whether adding a special type of radiation therapy (hypofractionated radiation) to the standard immunotherapy drug durvalumab is safe and effective for people with stage III non-small cell lung cancer. The treatment targets any remaining tumor after initial chemo…

This early-phase study tests whether combining two drugs—sarilumab (Kevzara) and cemiplimab—can help control certain types of advanced non-small cell lung cancer. About 56 adults with EGFR or LKB1/STK11 gene mutations will receive the combination. The main goal is to check safety…

This study looks at whether heavy smokers at high risk for lung cancer can be screened every two years instead of every year with low-dose CT scans, without missing early-stage cancers. It also offers a smoking cessation program to help participants quit. The goal is to make lung…

This study looks at whether fluid washed from inside the lungs during a bronchoscopy can find genetic changes in early-stage lung cancer. About 50 adults with suspected lung cancer will have this fluid tested with advanced genetic sequencing. The goal is to see if this method is …

This study tests a new radioactive imaging agent called [18F]-C-SNAT4 to see how it spreads in the body and whether it can help detect lung cancer tumors. About 20 healthy volunteers and people with lung cancer will receive the agent and have PET scans. The goal is to understand …

This study is testing a new blood test called DELFI to see how well it can detect lung cancer in people at high risk (current or former smokers aged 50+). About 12,000 participants will give a blood sample and have a standard CT scan. The goal is to see if the blood test is accur…

This study is testing a new blood test (GuardantLUNAR-2) to see how well it can find lung cancer in people at high risk. About 12,000 adults aged 50-80 who smoke or recently quit will give a blood sample and also get a standard low-dose CT scan. The goal is to see if the blood te…

This study looks at whether a large-scale lung cancer screening program can be set up in Germany. It involves 12,100 current or former smokers aged 55-79. The goal is to see which method (NELSON or PLCO) works best for finding lung cancer early, so treatment can start sooner.

This study compares a new approach using cone-beam CT and robotic-assisted bronchoscopy against standard methods for taking lung tissue samples. The goal is to see if the new technique improves the chance of getting a clear diagnosis for lung cancer or other lung diseases. About …

This study tests a new technology called breathprinting, or electronic nose (e-nose), to see if it can detect early-stage lung cancer. About 119 adults with a suspicious lung nodule will provide a breath sample, and the e-nose results will be compared to standard biopsy results. …

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study compares a robotic-assisted bronchoscopy system (Ion) with standard electromagnetic navigation for diagnosing lung nodules. About 354 adults with suspicious lung nodules will be randomly assigned to one of the two methods. The goal is to see which approach yields a mor…

This study looks at whether an artificial intelligence (AI) software called qXR can help doctors find lung cancer earlier by prioritizing chest X-rays that show suspicious signs. Researchers will compare how quickly patients get follow-up CT scans when AI is used versus standard …

This study is testing a robotic bronchoscopy system combined with real-time 3D imaging to see if it can more accurately reach and sample suspicious lung nodules. Researchers will enroll 132 adults with lung nodules to see how well the system performs and how quickly doctors learn…

This study is testing a new blood test called Lung EpiCheck to see if it can accurately detect early-stage lung cancer. It involves 5,000 current or former heavy smokers who are either getting a routine CT scan for screening or have a suspected or confirmed lung cancer diagnosis.…

This study tests whether a program combining low-dose aspirin, smoking cessation support, diet changes, and increased physical activity can lower chronic inflammation and prevent lung cancer in heavy smokers aged 55 to 75. Participants will also receive yearly low-dose CT scans f…

This study is testing a program to help more people at community health centers get screened for lung cancer. It uses text messages, educational videos, and telehealth support to guide patients through the screening process. The goal is to see if these tools make it easier for pe…

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This study looks at whether a 12-week program of online chair-based exercise and health education, combined with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if the program is practical and acceptable, and if it…

This study tests whether a text-message helper called 'Penny' can help lung cancer patients stick to their daily oral targeted therapy and manage side effects. About 75 adults with non-small cell lung cancer will either use Penny or get usual care. The goal is to see if real-time…

This study tests whether live exercise coaching plus a personalized digital app can improve quality of life for cancer survivors. About 146 adults with breast, lung, prostate, colorectal, or other cancers who had treatment in the last year will use the program for 18 months. Rese…

This study tests whether a smartphone app called AmDTx is practical for helping lung cancer patients manage anxiety before and after surgery. Six participants will use the app, which adjusts to each person's needs based on their doctor's instructions. The goal is to see if people…

This study tests whether using a special breathing device (AEROBIKA) after chest surgery can reduce the chance of a collapsed lung (atelectasis) in people with lung cancer or other chest tumors. About 72 participants will either get standard rehab or standard rehab plus the devic…

This study tests a brief educational and support program for 100 adults who have just finished lung cancer treatment with the goal of curing their cancer. The program is designed to help them adjust to life after treatment, reduce fear of the cancer coming back, and improve their…

This study tests whether a new imaging method can track lung tumors during radiation without needing to implant small markers (fiducials) around the tumor. It involves 5 adults with early-stage lung cancer or limited lung metastases who are already receiving standard radiation. T…

This study tests a new imaging system called HyperSight that takes clearer, faster 3D scans during radiation therapy for cancer. The goal is to see if these scans are good enough to help doctors plan treatment more accurately. About 40 adults with head and neck, breast, lung, upp…

This study tests whether a new method for lung cancer screening, called the Engaged Approach, is practical and acceptable for different screening programs. About 40 staff members from up to 8 programs across Colorado and the US will try it and give feedback. The goal is to see if…

This study tests whether reminder messages can encourage adults aged 40 to 80 who smoke or have smoked to get screened for lung cancer. Participants will receive reminders and then fill out questionnaires about how acceptable they find the messages. The goal is to learn which rem…

This study collects DNA from over 21,000 people with different cancers (like breast, colon, and lung) in New York. Researchers will look for inherited gene changes that might be linked to cancer. The goal is to find clues for future studies, not to test a treatment.

This study looks at the best way to collect tissue samples from people with suspected lung cancer during a routine ultrasound procedure. It compares taking 2 versus 3 samples from each lymph node to see which method provides enough material for genetic testing. The study also che…

This study looks at whether simple reminders and prompts for patients and their doctors can help more people get their yearly lung cancer scan. About 825 patients and their primary care doctors are taking part. The goal is to make sure people who are due for screening or follow-u…

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to learn how symptoms change over time, not…

This study tests a special camera that helps surgeons see and remove the first lymph node draining a lung tumor during surgery. The goal is to better detect if cancer has spread and to remove that node for analysis. About 57 adults with early-stage lung cancer are taking part. Th…

This study looks at 12 people with stage IV non-small cell lung cancer who are already receiving immunotherapy (nivolumab or pembrolizumab) and also get palliative radiation to the chest. The goal is to track side effects from the combination and how it affects patients' quality …

This study aimed to give firefighters low-dose chest CT scans to check for lung cancer and other lung diseases caused by smoke and chemical exposure. It focused on firefighters aged 35 and older who never smoked or quit long ago. The study was withdrawn before enrolling anyone, s…

This study tests a new computer program designed to reduce blurring in CT scans used during lung cancer radiation therapy, helping doctors locate tumors more accurately. It also checks how well the program tracks small markers placed in the lungs compared to using radio signals. …

This study looks at whether patient education and reminders can help more people get their yearly lung cancer screening. About 1,837 adults aged 50-78 who had a negative scan took part. The goal is to see if these simple tools improve repeat screening and early detection.

This study follows 45 uninsured current or former heavy smokers to find better ways to detect lung cancer early. Researchers collect blood samples, perform CT scans, and review medical records to test new screening methods. The goal is to catch lung cancer sooner in people who of…

This study looks at chest CT scans and breathing tests from over 2,000 World Trade Center workers and volunteers to better understand lung diseases like chronic airway disease, scarring, and cancer. Researchers want to see how these findings relate to symptoms and exposure to dus…

This study tests a very small camera, called a composite optical fiberscope, to see if it can reach and view lung tumors in the outer parts of the lung. Researchers will use lung tissue removed from 50 patients during surgery. The goal is to see if the camera can help doctors spo…

This study looks at whether a person's natural breathing pattern before surgery can help predict dangerous drops in oxygen levels during lung surgery. Researchers will measure breathing in 44 adults with lung cancer before the operation and track oxygen levels during the procedur…

This study looks at microplastic particles in the lungs of 119 patients, both with and without lung cancer. Researchers will collect fluid from the lungs during a routine procedure to measure how much plastic is there and what types. The goal is to understand if microplastic poll…

This study is testing whether artificial intelligence (AI) can combine blood biomarkers and CT scan images to more accurately predict lung cancer risk in heavy smokers. Researchers will analyze data from 650 current or former heavy smokers to see if these tools can better identif…

This study looks at whether a new way of paying for cancer care can help doctors work together better and improve health outcomes for patients with breast, colon, or lung cancer. The study involves 7 participants and compares the new payment model to the usual way of paying for c…

This study looks at two methods to help people with lung cancer hold their breath during a special type of radiation called SBRT. One method uses a camera system (SGRT) alone, and the other adds small markers placed in the lung. The goal is to see which method is safer and more r…

This study looks at whether certain inherited gene changes (EGFR mutations) increase the risk of lung cancer, especially in people who never smoked. Researchers collect saliva from cancer patients with a specific tumor mutation (T790M) to see if they carry an inherited mutation. …

This study tracks 126 adults aged 50 to 74 who are at high risk for lung cancer due to heavy smoking. The goal is to see how many actually complete their low-dose CT scans as part of a screening program. Researchers also look at how many refuse screening, quit smoking, and the ra…

This study looks at whether a PET scan using a special tracer called FAZA can detect low oxygen levels (hypoxia) in lung cancer tumors. Hypoxia can affect how tumors grow and respond to treatments like radiation. About 36 adults with stage II or III lung cancer will receive one F…

This study looks at what helps increase lung cancer screening in people aged 50-80 who smoke or used to smoke. Researchers will test two different ways to encourage screening and compare them to usual care. About 2,869 participants from UC Davis clinics will take part. The goal i…

This study looks at whether a newer biopsy method called transbronchial cryobiopsy (using a freezing tool) is safer than the standard method for taking lung tissue samples. About 100 adults with known or suspected cancer will take part. The goal is to see if this technique causes…

This study is looking at whether having low muscle mass (sarcopenia) before lung cancer surgery affects how well patients recover. Researchers are following 400 older adults who are having surgery to remove lung cancer. They want to see if muscle loss can help predict survival an…

This study looks at how lung cancer patients and their doctors communicate during appointments. Researchers want to understand how these conversations affect patient well-being and outcomes. About 294 patients will take part, sharing their experiences through interviews and quest…

This study involves 30 adults with lung cancer who are taking oral targeted therapy (TKIs). Participants use a smartphone app, a Fitbit, and a smart pill cap for up to 24 weeks to track symptoms and medication use. The goal is to see if this remote system is practical and to guid…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…

This study collects blood, tumor tissue, and other body fluids from 1,000 adults with lung cancer, thymus cancer, or mesothelioma. Researchers analyze these samples to find biological markers that could predict how cancer will behave or respond to treatments. The goal is to impro…

This study looks at whether a new imaging method, called needle-based confocal laser endomicroscopy (nCLE), can confirm that a biopsy needle has reached a lung nodule. About 25 adults with suspected lung cancer will have nCLE added to their standard biopsy procedure. The goal is …

This study works with the Choctaw Nation to find better ways to get people screened for lung cancer. Researchers will talk to patients and doctors to understand barriers, then test a program that helps eligible people get screened and quit smoking. The goal is to catch lung cance…