Supercharged immune cells take on advanced cancers
NCT ID NCT05902520
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new approach to treat advanced solid tumors by giving patients a large dose of their own immune cells that are specially selected to attack cancer. The cells are taken from the tumor, multiplied in the lab, and then infused back. Some patients also receive cells that have been modified to reduce a brake on their activity. The study aims to see if this treatment is safe and whether it can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tumor-infiltrating lymphocytes (TILs) with or without PD-1 gene silencing
- What this could lead to
- If successful, this could point toward a more effective cell therapy for advanced solid tumors by using only the most tumor-reactive immune cells.
- What could go wrong
- This is an early Phase 1 trial with only 18 participants, so safety and effectiveness are not yet proven. The treatment involves intensive chemotherapy and may cause serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Providence Portland Medical Center
Portland, Oregon, 97213, United States
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