Cancer resistance secrets revealed in massive genetic study

NCT ID NCT03347318

First seen Mar 19, 2026 · Last updated Jun 15, 2026 · Updated 9 times

Summary

This study aims to understand why some solid tumors stop responding to targeted therapies by analyzing their genetic profiles. Researchers will collect blood, saliva, and tumor samples from 2500 people with various cancers, including colorectal, breast, lung, and rare tumors. Some tumor samples will be grown in mice to study how genetic changes affect drug response. The goal is to improve future treatment decisions, not to test a new therapy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. Città della Salute e della Scienza di Torino - Presidio ospedaliero Ostetrico Ginecologico Sant'Anna

    Turin, Italy

  • AOU Città della Salute e della Scienza di Torino - Presidio Molinette

    Turin, Italy

  • AOU S. Luigi Gonzaga

    Orbassano, Italy

  • Azienda Ospedaliera Niguarda Ca'Granda

    Milan, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Italy

  • Azienda Ospedaliero-Universitaria Careggi

    Genova, Italy

  • Fondazione IRCCS - Istituto Nazionale dei Tumori

    Milan, Italy

  • IEO - Istiuto Europeo di Oncologia

    Milan, Italy

  • IOV - Istituto Oncologico Veneto

    Padova, Italy

  • Istituto Di Candiolo - Fondazione Del Piemonte Per L'Oncologia (FPO-Irccs)

    Candiolo, Italy

  • Ospedale Mauriziano Umberto I

    Turin, Italy

  • Ospedale Regionale Umberto Parini

    Aosta, Italy

  • Policlinico S.Orsola Malpighi

    Bologna, Italy

  • Policlinico Universitario Campus Biomedico

    Roma, Italy

  • Presidio Ospedaliero Martini

    Turin, Italy

Conditions

Explore the condition pages connected to this study.