Experimental virus therapy takes on Drug-Resistant lung cancer
NCT ID NCT06125197
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-stage trial tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment combines a specially designed virus (TILT-123) that delivers immune-boosting signals directly into tumors, with the immunotherapy drug pembrolizumab. The study aims to find a safe dose and check for side effects in about 22 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TILT-123 (a modified virus that delivers immune-boosting proteins) combined with pembrolizumab (an immunotherapy drug)
What this could lead to
If it works, this could offer a new treatment option for people with advanced lung cancer whose current immunotherapy has stopped working.
What could go wrong
This is a very early, small Phase 1 trial focused on safety, not yet on effectiveness. The virus may cause side effects or fail to shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92658, United States
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UCLA Jonsson Comprehensive Cancer Center
Santa Monica, California, 90404, United States