Glowing dye could help surgeons spot hidden lung cancer spread

NCT ID NCT00264602

Ongoing Knowledge-focused Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests whether a dye called indocyanine green, injected near a lung tumor during surgery, can help surgeons see and remove the first lymph node that drains from the cancer. The goal is to improve detection of cancer spread and guide more precise treatment. The trial involves 57 adults with operable lung cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indocyanine Green (a dye) injected near the tumor during surgery
What this could lead to: If successful, this technique could help surgeons more accurately identify and remove the lymph node most likely to contain cancer cells, potentially improving staging and treatment decisions for lung cancer patients.
What could go wrong: This is a very early (Phase 1) trial with only 57 participants, so results may not apply to all lung cancer patients. The dye or imaging might not reliably find the correct lymph node, and the procedure carries standard surgical risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02115, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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