No-Marker tumor tracking could make lung cancer radiation safer

NCT ID NCT04310891

Ongoing Knowledge-focused Sponsor: Royal North Shore Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new X-ray technique to track lung tumors during radiation without needing implanted markers. Five adults with early-stage lung cancer will be observed to see if the markerless method matches the standard marker-based tracking within 3 millimeters. If it works, it could make radiotherapy less invasive and more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Markerless Tumour Tracking (intrafraction kilovoltage X-ray imaging)
What this could lead to: If successful, this could make lung cancer radiotherapy more accurate and less invasive by removing the need for implanted markers.
What could go wrong: This is a very small, early-phase study with only 5 participants, so results may not apply to all patients. The tracking method may not be accurate enough for routine use.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRAFRACTION KOLOVOLTAGE X-RAY IMAGING LUNG CANCER MARKERLESS IMAGE GUIDANCE

Contacts and locations

Locations

Royal North Shore Hospital

Saint Leonards, New South Wales, 2065, Australia

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