LUNG CANCER

This early-stage trial tested adding an approved lung fibrosis drug, pirfenidone, to standard first-line chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe combined dose and get early signs of whether the combination could help sh…

This study aimed to find out if a less invasive surgery (removing only part of a lung lobe) works as well as the standard surgery (removing the entire lobe) for small, early-stage lung cancers. It involved 701 patients with tumors 2 cm or smaller. The goal was to see if the small…

This study tested a new surgical technique to help surgeons find and remove small lung nodules more accurately. Researchers used real-time CT imaging during minimally invasive surgery to guide the procedure. The goal was to see if this approach was safe and effective for patients…

This study tested whether adding a specialized geriatric care team to standard cancer treatment could help older patients. It involved 792 patients aged 70 and older with various advanced cancers. The goal was to see if this coordinated care approach improved survival and quality…

This study tested whether a common breathing device (CPAP) could make radiation therapy safer for people with lung cancer or left-sided breast cancer. Researchers wanted to see if using the CPAP device during treatment planning could reduce the amount of radiation that reaches he…

This study tested whether adding addiction treatment directly to cancer care helps patients quit smoking and drinking. It involved 133 adults newly diagnosed with head/neck or lung cancer who were regular smokers. Researchers compared patients who received integrated addiction tr…

This early-stage trial tested a new oral drug, VS-6766, given alone and later combined with another drug called everolimus. The main goal was to find safe and tolerable dosing schedules for patients with advanced solid tumors or multiple myeloma that had stopped responding to sta…

This small pilot study tested a program designed to help lung cancer patients quit smoking and prevent relapse. The program combined phone coaching, educational videos, and standard quit-smoking support. Researchers measured whether patients found the program helpful and complete…

This study tested if a new augmented reality (AR) system could help surgeons find small lung nodules just as well as the standard CT-guided needle method, but with less pain and radiation. It involved 270 patients with small lung nodules needing surgery. Researchers compared the …

This early-stage trial tested the safety and best dose of a two-drug combination for people with advanced lung cancer driven by a specific KRAS gene change. The study involved 34 adults and combined two oral medications, palbociclib and binimetinib, which work together to block d…

This study tested a telehealth support program to help people complete their recommended annual follow-up scans for lung cancer screening. Researchers worked with patients and healthcare providers to design the program, then offered it to a small pilot group. The main goal was to…

This study tested whether adding an experimental drug called AZD1775 to standard chemotherapy (carboplatin and paclitaxel) could help control advanced squamous cell lung cancer. It involved 42 adults whose cancer had spread and had no known curative options. The main goal was to …

This study tested if adding a common, inexpensive beta blocker (a type of heart/blood pressure medication) to a standard immunotherapy drug (camrelizumab) could make the cancer treatment work better for people with advanced non-small cell lung cancer. Researchers enrolled 59 pati…

This study tested a combination of three drugs—nivolumab, ipilimumab, and plinabulin—for patients whose small cell lung cancer had returned after initial chemotherapy. The goal was to find a safe dose and see if the combination could help control the cancer. The trial involved 39…

This study provided continued access to the cancer drug bintrafusp alfa for 22 patients who had previously benefited from it in earlier trials. Its main goal was to collect long-term safety information and track how long patients lived after treatment. Researchers followed patien…

This early-stage study tested a new cancer vaccine designed to teach the body's immune system to recognize and attack tumors. It involved 43 people with advanced colorectal, lung, breast, or prostate cancer that had stopped responding to standard treatments. The main goals were t…

This study tested whether adding a new drug called itacitinib to an existing lung cancer medication (osimertinib) is safe and effective. It involved 59 adults with advanced non-small cell lung cancer that had specific genetic changes (EGFR and T790M mutations) and had stopped res…

This study tested a new blood test called OncoSweep to see if it can help detect lung cancer. Researchers collected blood samples from 109 people—some with lung nodules and some without—to compare the results. The goal is to see if this test can provide extra information to help …

This study tested whether adding a specific biopsy procedure (EBUS-TBNA) after a standard PET/CT scan could more accurately determine the stage of early lung cancer. It involved 150 patients with early-stage non-small cell lung cancer who were being evaluated for a targeted radia…

This study tested whether giving primary care doctors access to a blood test for lung cancer screening would encourage more eligible patients to get checked. It focused on patients who were at high risk due to smoking history but were not getting the recommended CT scans. Researc…

This study tested a new computer system called RUS Lung that creates a 3D map from a patient's CT scan to help guide surgeons during minimally invasive lung cancer surgery. It involved 34 patients and aimed to see if the system was practical to use and if it helped surgeons accur…

This study tested a new scanning method to see if it could make PET scans better at finding small lung tumors. It involved 103 adults who had small lung nodules. Researchers compared images from a standard PET scan to images from a new scan that was timed with the patient's breat…

This study tested a new, combined robotic system designed to improve the accuracy of lung nodule biopsies. It involved 155 adults with small lung nodules (2 cm or smaller) to see how well the system could guide a needle directly into the nodule for a tissue sample. The main goal …

This study tested a robotic system designed to help doctors more accurately place biopsy tools inside small lung nodules. It involved 200 adults in Europe who needed a biopsy because they were at moderate to high risk for lung cancer. The main goal was to see how often the roboti…

This study tested whether adding a social needs assessment and support to standard lung cancer screening education could get more at-risk people to actually get screened. Researchers worked with 101 adults in New Jersey who were eligible for screening due to their smoking history…

This study tested a program designed to help more eligible patients get screened for lung cancer. It involved reminding doctors, educating patients, offering financial help, and prompting discussions during check-ups. The goal was to see if this approach led to more people gettin…

This project tested whether a community support program could help more people in Philadelphia get to their scheduled lung cancer screenings. Researchers offered free help with transportation to and from appointments for 252 eligible city residents. The goal was to see if this pr…

This study tested a community support program to help people in West Philadelphia get to and attend their scheduled lung cancer screening appointments. The program offered phone support from a representative and free Lyft rides to the hospital. Researchers measured whether this e…

This study tested whether watching 360° virtual reality movies could help reduce fear and anxiety in cancer patients about to begin radiation therapy. Researchers enrolled 292 adults with breast, lung, prostate, head and neck cancers, or brain tumors. Patients watched VR movies s…

This study tested whether a structured program of breathing exercises and early movement after lung cancer surgery helps patients recover faster. It involved 60 patients aged 45-90 who received daily physiotherapy during their hospital stay. Researchers compared recovery times an…

This study tested whether a structured education session before lung cancer surgery helps patients recover better. One hundred patients were randomly assigned to either receive this special nurse-led education or the hospital's standard care. Researchers then compared their pain …

This study tested a new approach to managing side effects during cancer radiation treatment. It involved 104 patients with lung or gastrointestinal cancers. The goal was to see if having patients directly report their symptoms to their doctors each week led to better detection an…

This study tested a home-based exercise program designed to help people manage severe fatigue after lung cancer surgery. Researchers worked with 235 patients who had non-small cell lung cancer to see if starting exercises right after surgery or waiting 6 weeks worked better. The …

This study followed 385 people newly diagnosed with lung or head/neck cancer to understand how many continue using tobacco and alcohol during their first year of treatment. Researchers tracked patients' substance use patterns to identify factors that make quitting difficult. The …

This study tested a new type of CT scanner used during radiation therapy to see if it could produce clearer images. It involved 41 adults receiving radiation for cancers in areas like the head, neck, lung, breast, abdomen, or pelvis. The goal was to see if the improved images cou…

This study tested whether targeted Facebook ads and an online educational tool called 'LungTalk' could increase awareness and encourage more people at high risk for lung cancer to get screened. Researchers enrolled over 500 adults with a significant smoking history to see if this…

This study tested whether smartphones and smartwatches could be used to reliably measure symptoms like fatigue and changes in activity in cancer patients. Researchers enrolled 49 adults with various cancers who were already receiving treatment. They used iPhones and Apple Watches…

This study tested a new automated system to see if it could grow cancer cells from patients with advanced metastatic cancer inside chicken eggs. The goal was to create a faster, cheaper research model to help scientists study cancer and test potential drugs. The study involved 10…

This study aimed to understand if the body's natural daily rhythm (circadian rhythm) influences how lung cancer cells spread through the bloodstream. It followed 27 patients with advanced lung cancer for one year, taking blood samples before they started treatment. The goal was t…

This study aimed to understand how lung cancer treatment affects a patient's physical strength, activity levels, and overall well-being. Researchers followed 150 patients receiving treatment, measuring their fitness and symptoms at different points. The goal was to learn why pati…

This study observed 535 patients in France with advanced non-small cell lung cancer who were already scheduled to receive the drug nivolumab after prior chemotherapy. Its purpose was to collect real-world information on how long the treatment worked, its side effects, and how it …

This study aimed to understand how people with lung cancer develop and maintain immunity after getting COVID-19 or receiving a COVID-19 vaccine. Researchers observed nearly 2,000 patients across Spain, checking their blood for protective antibodies at different times. The goal wa…

This study aimed to understand how lung cancer affects patients' sexual health. Researchers surveyed 553 lung cancer patients to learn about the types, frequency, and severity of sexual problems they experience. The goal is to use this information to create better support strateg…

This study aimed to understand if firefighters have different lung scan results compared to non-firefighters, and if their job exposures are linked to these findings. Researchers compared lung scans from over 700 current and retired firefighters with over 1,100 similar non-firefi…

This study tested whether new AI software could help doctors plan radiation therapy more accurately and quickly than traditional manual methods. Researchers compared three ways of outlining organs on CT scans from 500 patients with lung, breast, or esophageal cancer. The goal was…

This study aimed to collect and store biological samples from thousands of tin miners in China who are at very high risk for lung cancer. The goal was to create a 'biobank' of samples to help researchers find early warning signs of the disease and understand what causes it. Parti…

This study tested a training program called KanSurvive-ECHO to help rural primary care doctors provide better follow-up care for people who have finished treatment for breast, colorectal, lung, or prostate cancer. Researchers worked with 20 rural clinics to identify gaps in care …