LUNG CANCER

This study tested a new, faster way to give radiation therapy for small lung tumors. Instead of the usual two to three weeks of planning and multiple visits, the goal was to complete the entire treatment in just one day. Ten patients with early-stage lung cancer or limited lung m…

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced cancers (colorectal, lung, breast, or prostate) that make a protein called CEA. The vaccine uses a modified virus to teach the immune system to attack cancer cells. The main goals were to check safety a…

This study looked at whether offering a structured program to help patients quit smoking and reduce alcohol use, as part of their initial cancer treatment, works better than just giving advice. It included 133 adults with a first-time head/neck or lung cancer who were still smoki…

This early-stage study tested a new drug (BI 765049) alone or with another drug (ezabenlimab) in 21 Asian adults with advanced solid tumors like lung, stomach, or liver cancer. The goal was to find a safe dose and see if the drugs could shrink tumors. Participants received infusi…

This study tested a new way to remove small lung nodules using a CT scanner during surgery. 25 patients with small, outer-edge lung tumors were treated. The goal was to see if the approach is safe and can successfully remove the nodules. The technique aims to make surgery more pr…

This early-phase study tested an experimental drug called VS-6766, given by mouth on different schedules, in 104 adults with advanced solid tumors or multiple myeloma. The goal was to find a safe and tolerable dose, both when used alone and when combined with another drug (everol…

This early-stage study tested a new drug called COM902, alone or with another drug (COM701), in 94 people with advanced cancers like ovarian, lung, colon, and multiple myeloma. The main goal was to check safety and find the best dose. While not a cure, the approach aims to contro…

This study tested whether adding a precise, high-dose radiation treatment (CyberKnife) after standard chemo and radiation could improve outcomes for people with stage III non-small cell lung cancer. It involved 35 patients whose tumors had not spread but could not be removed by s…

This early-phase trial tested whether adding the drug pirfenidone to standard chemotherapy is safe and effective for people with advanced non-small cell lung cancer. 48 participants received the combination to find the best dose and see if tumors shrank. The goal was to control t…

This early-phase trial tested a combination of two targeted drugs (palbociclib and binimetinib) in 34 people with advanced lung cancer that has a specific KRAS gene change. The main goal was to find the safest dose and check for early signs of tumor control. While not a cure, thi…

This study tested a program to help people with lung cancer stop smoking. Researchers worked with 263 patients to provide support and medication. The goal was to see if the program could help more patients quit and improve how doctors document tobacco treatment.

This study compared two types of surgery for people with small (≤2 cm) early-stage lung cancer: removing the entire lobe (lobectomy) versus removing only the tumor and a small margin (sublobar resection). The goal was to see if the less invasive approach works just as well with f…

This study followed 22 adults with lung cancer or other cancers who were already taking the drug bintrafusp alfa in earlier trials. The goal was to keep giving them the drug and watch for side effects and how long they lived. It is not a cure, but a way to manage the disease over…

This study tested a new drug combination (itacitinib plus osimertinib) in 59 adults with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation). The goal was to see if the combination is safe and helps shrink tumors. Participants received both drug…

This study tested a combination of three drugs (nivolumab, ipilimumab, and plinabulin) in 39 adults with recurrent small cell lung cancer that had worsened after initial chemotherapy. The goal was to find the safest dose of plinabulin and see if the combo could shrink tumors or d…

This study looked at whether a care plan led by a geriatrician and a nurse could help older adults (70+) with cancer live longer and feel better. It included 792 people with different cancers like breast, lung, or prostate. The approach was compared to usual cancer care to see if…

This study tested whether adding the drug AZD1775 to standard chemotherapy (carboplatin and paclitaxel) helps people with advanced squamous cell lung cancer live longer without their cancer growing. 42 participants received the combination. The main goal was to see how long it to…

This study tested a new smart probe that uses electrical signals to tell the difference between healthy lung tissue and tumors during a biopsy. 30 adults with lung lesions had the probe used during their procedure. The goal was to see if the probe could accurately identify cancer…

This study compared a new type of PET scan (68Ga-FAPI) to the standard FDG-PET scan in 58 people with known or suspected lung cancer. The goal was to see if the new scan could more accurately find and stage lung tumors. Participants received both scans, and results were checked a…

This study tested a special fluorescent dye called VGT-309 that makes lung cancer cells glow during surgery. About 89 people with known or suspected lung cancer received the dye before their operation, allowing surgeons to see tumors that standard methods might miss. The goal was…

This study collected blood samples from 109 adults, some with lung cancer and some without. The goal was to use these samples to develop and validate a new blood test called OncoSweep that can tell the difference between cancer and non-cancer signals. This test aims to help detec…

This study looked at whether low-dose CT scans can help find lung cancer early in people with HIV who have a history of heavy smoking. About 450 participants aged 40 and older were scanned. The goal was to measure how many lung cancers were found and to learn more about the types…

This study looked at whether adding a special ultrasound-guided needle test (EBUS-TBNA) after a standard PET/CT scan can more accurately stage early-stage non-small cell lung cancer. About 150 adults with stage I-IIA lung cancer who were being considered for precise radiation the…

This study tested a new way to biopsy small lung nodules (≤2 cm) using a robotic system called Ion and a special 3D imaging machine called Cios Spin. The goal was to see how accurate and safe the biopsy procedure is. 155 adults took part, and the study measured how often the need…

This study tested whether a robotic bronchoscopy system, guided by real-time 3D CT scans, can more accurately biopsy lung nodules. 200 adults with suspicious lung nodules took part. The goal was to see how often the biopsy tool reached the exact nodule location before sampling, w…

This study tested a tool called MyLungHealth, delivered through a patient portal, to see if it could increase lung cancer screening rates. Over 31,000 people aged 50-79 with a smoking history took part. The tool helped identify who was eligible for screening and encouraged them t…

This study tested a special way of taking PET scans that accounts for breathing movements. The goal was to see if it could better detect small lung nodules in 103 patients with lung cancer or COPD. Participants had a standard PET scan plus an extra 10-minute scan while following …

This pilot study tested a 10-week virtual group program called Mindful Self-Compassion for Lung Cancer (MSC-LC) in 79 adults with lung cancer who felt stigmatized. Participants were randomly assigned to the program or a waitlist that received mental health resources. The goal was…

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched VR movies and then…

This study tested a program to help people with lung cancer stop smoking and stay smoke-free. 21 adults with lung cancer who smoked took part. The program included counseling and support to help them quit and avoid starting again.

This study tested whether augmented reality (AR) can replace the standard CT-guided hook-wire method for locating small lung nodules before surgery. 270 adults with lung nodules up to 2 cm took part. The goal was to see if AR could make the process faster, less painful, and just …

This study looked at whether a home-based exercise program can help people with non-small cell lung cancer manage severe tiredness after surgery. 235 adults took part. The program was designed to be simple, safe, and low-cost. The goal was to reduce fatigue and improve quality of…

This study tested a structured program of breathing exercises, chest therapy, and early movement in 60 adults aged 45-90 who had lung cancer surgery. The goal was to see if the program could shorten hospital stays and improve recovery. Researchers measured hospital length, vital …

This study tested whether a simple walking program, tracked with fitness trackers, could help people with various cancers (brain, head and neck, lung, gastrointestinal, or cervical) complete their planned chemoradiotherapy without missing treatments. 166 adults who could walk ind…

This study looked at whether a special education session before lung cancer surgery helps patients recover faster. 100 adults were split into two groups: one got a nurse-led lesson with a booklet, the other got usual care. Researchers measured pain, breathing, and overall recover…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is linked to…

This study looked at whether the body's natural 24-hour cycle (circadian rhythm) influences the spread of tumor cells in the blood of people with advanced lung cancer. Researchers collected blood samples from 27 patients before they started cancer treatment. The goal was to bette…

This study tested a brief virtual mindfulness program designed to reduce stigma and health disparities among lung cancer patients, especially those from underserved groups. Researchers worked with a community advisory board of lung cancer patients to build the program. The goal w…

This study tested whether free, open-source 3D lung reconstructions could help surgeons perform lung cancer surgery. Thirteen patients scheduled for lung cancer surgery had 3D models created from their CT scans. The study measured how usable the models were and whether they accur…

This study tested whether an AI-assisted software (iCurveE) helps doctors more accurately and quickly outline organs at risk on CT scans for radiation therapy. 500 adults with lung, breast, or esophageal cancer participated. Researchers compared manual contouring, AI-only, and AI…

This project offered free transportation coordination to help people in Philadelphia attend lung cancer screening appointments. The study included 252 adults who had upcoming or missed low-dose CT scans. Researchers compared attendance among those who used the free rides, those w…

This study tested a new type of CT scanner that takes pictures during radiation therapy for lung, liver, breast, and other cancers. The goal was to see if the new scanner produces clearer images with fewer distortions. 31 people participated, and the results will help doctors bet…

This study tested a program to help Hispanic/Latinx patients get screened for lung cancer. 60 eligible adults received either extra support (education, reminders, and financial help) or usual care. The goal was to see if the program increased the number of people who got a low-do…

This study looked at whether giving doctors access to a blood test called FirstLook (which looks for DNA fragments linked to lung cancer) would encourage more eligible patients to get screened. The study involved 28 primary care practices and patients who were at high risk for lu…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study tested a new automated method to grow cancer cells from patients with metastatic cancers (like prostate, breast, lung) inside chicken eggs. The goal was to see if this system could successfully grow tumors from patient samples, which could help doctors study cancer and…

This study tested whether iPhones and Apple Watches can help monitor symptoms and activity levels in people with cancer. 49 adults receiving cancer treatment at the NIH wore an Apple Watch and used an iPhone for 4 months. The goal was to see if these devices could reliably measur…

This study looked at sexual problems in 553 adults with lung cancer to understand how common and severe they are. Researchers aimed to find patterns that could help doctors provide better support during cancer care. The study did not test any treatments, only gathered information…

This study looked at whether firefighters have different lung scan results compared to non-firefighters. Researchers used low-dose CT scans to check for lung nodules and other lung diseases in 734 current and retired firefighters. The goal was to better understand how job-related…

This study tested a program called KanSurvive-ECHO to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers worked with 15 clinics to improve tasks like scheduling cancer screenings, checking for distress, and tracking weight and tobacco …

This study followed 535 people in France with advanced non-small cell lung cancer who were already prescribed nivolumab after at least one round of chemotherapy. Researchers observed how long treatment worked, side effects, and quality of life in real-world settings. The goal was…

This study tested a community support program (CSP) to see if it helps people attend lung cancer screening appointments. Researchers compared attendance rates among West Philadelphia residents who opted into the program, those who did not, and a group from another area. The goal …

This study looked at chemical markers in blood, lung tissue, and breath from 74 people with lung nodules. Researchers compared samples from 22 people with non-small cell lung cancer to 20 with benign nodules. They used advanced lab methods to find differences that could one day h…

This study looked at 385 adults diagnosed with their first lung or head and neck cancer to see how many kept using tobacco or alcohol during the first year. Researchers tracked smoking and drinking habits, as well as cancer progression and survival. The goal was to understand ris…

This study followed 150 people with lung cancer to see how their treatment (surgery, chemo, or radiation) affected their physical abilities, symptoms, and quality of life. Researchers measured things like walking distance, strength, and daily activity levels. The goal was to unde…

This study tested whether helping people with social needs (like housing, food, or transportation) increases the number of high-risk adults who get screened for lung cancer. About 101 current or former smokers aged 50–80 took part. One group received standard education about lung…

This study tested a new type of CT scanner that takes pictures while patients lie on the treatment couch during radiation therapy for cancer. The goal was to see if the images were clear enough to help doctors aim radiation more precisely. 41 adults with head and neck, lung, brea…

This study gathered information from 101 patients and healthcare providers to design a care pathway for COPD in people with lung or head and neck cancer. The goal was to reduce treatment burden and overcome common barriers to COPD care in community oncology clinics. Researchers u…

This study looked at 60 people with advanced lung cancer who were receiving immunotherapy. Researchers checked if taking beta-blockers (a common blood pressure medicine) at the same time changed how well the cancer treatment worked. They compared tumor shrinkage, time until cance…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation, such as l…

This study looked at whether asking cancer patients to report their own symptoms during radiation treatment helps doctors notice and manage side effects better. 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sympto…

This study tested a new way to help surgeons find small lung nodules during a type of keyhole surgery called VATS. Doctors used a special CT scanner in the operating room to place tiny metal markers (microcoils) near the nodules before removing them. The goal was to see how much …

This study tested a new 3D navigation system called RUS Lung to help surgeons find lung tumors during minimally invasive surgery. 34 adults with small lung cancers (tumors 3 cm or smaller) took part. The main goal was to see if the system could accurately match the tumor's locati…

This study tested a telehealth program to help people remember to get their yearly lung cancer screening. 22 people who were overdue for their follow-up scan took part. The goal was to see if video calls could make it easier to complete the screening on time.

This study created a large collection of biological samples (like sputum, blood, and urine) from over 9,700 tin miners in China who are at high risk for lung cancer due to exposure to radon, arsenic, and tobacco. The goal was to identify early markers of lung cancer to improve de…

This small study looked at whether using a CPAP machine during radiation therapy can reduce the amount of radiation reaching the lungs in people with left-sided breast cancer or lung cancer. Eight patients were enrolled to compare lung radiation doses with and without CPAP. The g…

This study looked at nearly 2,000 adults with lung cancer who caught COVID-19. Researchers collected medical records and blood tests to understand how their immune systems responded. They also checked antibody levels 6 months after COVID vaccination. The goal was to learn more ab…

This study tested a program to help more people get screened for lung cancer. The program included reminders for doctors, education for patients, help with costs, and prompts to talk about screening during visits. The goal was to see if these steps would increase the number of pe…

This study tested whether Facebook ads and a tailored online tool called LungTalk could increase awareness and knowledge about lung cancer screening among high-risk individuals. Over 500 current or former heavy smokers participated. The goal was to see if social media can effecti…

This study looked at whether a video-call exercise program can help people recover after lung cancer surgery. 36 patients aged 55-75 who had part of a lung removed took part. The program aimed to improve breathing, strength, and quality of life from home.