New cocktail of immune drugs shows promise in lung cancer trial

NCT ID NCT04262856

Completed Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tested three different drug combinations in 151 people with advanced non-small cell lung cancer that had not been treated before. The drugs help the immune system attack cancer cells. Researchers measured how many patients' tumors shrank or stopped growing, and how long they lived without the cancer getting worse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zimberelimab, domvanalimab, and etrumadenant (three drugs that help the immune system fight cancer)
What this could lead to: If successful, this could point toward a more effective first-line treatment for advanced non-small cell lung cancer by combining immune-boosting drugs.
What could go wrong: This is a phase 2 trial with only 151 participants, so results are still early. The drug combinations may cause immune-related side effects and may not improve survival compared to existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER NON-SMALL CELL LUNG CANCER NONSQUAMOUS NON SMALL CELL LUNG CANCER SQUAMOUS NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Adelaide Cancer Centre

Elizabeth Vale, Australia
Allegheny General Hospital (AGH)-Alleghney Singer Research Institute

Pittsburgh, Pennsylvania, 15224, United States
Asan Medical Center

Seoul, South Korea
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Border Medical Oncology

Albury, Australia
Catholic University of Korea, Uijeongbu St. Mary's Hospital

Uijeongbu-si, South Korea
Chang Gung Memorial Hospital at Linkou

Taoyuan, Taiwan
Chi Mei Hospital

Tainan, Taiwan
Chonbuk National University Hospital

Jeonju, South Korea
Chonnam University Hospital

Hwasun, South Korea
Chungbuk National University Hospital (CBNUH)

Cheongju-si, South Korea
Clinical Research Alliance

Lake Success, New York, 11042, United States
Coffs Harbour Health Campus

Coffs Harbour, Australia
Curie Oncology

Singapore, Singapore
Florida Cancer Specialists

Englewood, Florida, 34223, United States
Florida Cancer Specialists

Gainesville, Florida, 32605, United States
Florida Cancer Specialists - East

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists - Panhandle

Tallahassee, Florida, 32308, United States
Gachon University Gil Medical Center

Incheon, South Korea
Hong Kong United Oncology Centre

Hong Kong, Hong Kong
Innovative Clinical Research Institute (ICRI)

Whittier, California, 90603, United States
Kangbuk Samsung Hospital

Seoul, South Korea
Korea University Anam Hospital

Seoul, South Korea
Kosin University Gospel Hospital

Busan, South Korea
McGill University Health Centre (MUHC) - The Montreal Children's Hospital (MCH)

Montreal, Canada
Millennium Oncology

Houston, Texas, 77339, United States
National Cheng Kung University Hospital

Tainan, Taiwan
National Taiwan University Hospital

Taipei, Taiwan
Northwell Health Cancer Institute

Lake Success, New York, 11042, United States
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care

Blacksburg, Virginia, 24060, United States
Queen Elizabeth Hospital (Hong Kong)

Hong Kong, Hong Kong
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Seoul National University Bundang Hospital

Seongnam-si, South Korea
Shoalhaven Cancer Care Centre

Nowra, Australia
St Vincent Hospital of the Catholic University of Korea

Suwon, South Korea
Taipei Medical University - Shuang Ho Hospital

New Taipei City, Taiwan
Taipei Medical University Hospital

Taipei, Taiwan
The Center For Cancer And Blood Disorders (Texas Cancer Care)

Fort Worth, Texas, 76104, United States
The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion

Ridgewood, New Jersey, 07450, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States

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