New combo therapy targets advanced tumors in early trial

NCT ID NCT00600496

First seen Nov 14, 2025 · Last updated May 14, 2026 · Updated 22 times

Summary

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find the best dose. About 140 participants will take AZD6244 pills twice daily alongside their chemo, and researchers will monitor side effects and how the drugs move through the body.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Detroit, Michigan, 48201, United States

  • Research Site

    Philadelphia, Pennsylvania, 19111, United States

  • Research Site

    Nashville, Tennessee, 37203, United States

  • Research Site

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.