Breath test could revolutionize lung cancer detection

NCT ID NCT06193239

Completed Diagnosis Sponsor: Owlstone Ltd Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study is testing a new breath test called OWL-EVO1 to see if it can accurately tell the difference between people who have lung cancer and those who do not. The test involves breathing into a device after taking a special probe. Researchers are enrolling adults aged 45-85 who have had a recent chest CT scan. If the test works well, it could become a simple, non-invasive tool for lung cancer screening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: OWL-EVO1 Breath Biopsy Test (D5-ethyl-βD-glucuronide EVOC probe)
What this could lead to: If successful, this breath test could offer a non-invasive, quick way to help detect lung cancer earlier, potentially improving outcomes.
What could go wrong: This is a Phase 2a study with 187 participants, so results are preliminary. The test may not prove accurate enough for widespread use, and breath sampling can be technically challenging.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER

Contacts and locations

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Locations

Barts Health NHS Trust

London, London, E1 1FR, United Kingdom
Department of Pulmonology, University of Debrecen

Debrecen, Debrecen, H-4032, Hungary
Glenfield Hospital

Leicester, Leicestershire, LE3 9QP, United Kingdom
Imperial Centre for Translational and Experimental Medicine, Imperial College

London, London, W12 0HS, United Kingdom
National Koranyi Institute for Pulmonology

Budapest, Budapest, H-1121, Hungary
Quadram Institute

Norwich, Norfolk, NR4 7UQ, United Kingdom
Royal Papworth Hospital NHS Foundation Trust

Cambridge, Cambridgeshire, CB2 0AY, United Kingdom
Thomayer Hospital

Prague, Prague, 140 59, Czechia
Wythenshawe Hospital

Manchester, Greater Manchester, M23 9LT, United Kingdom

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