New drug combo targets hard-to-treat lung cancer gene

NCT ID NCT03170206

First seen Feb 20, 2026 · Last updated May 13, 2026 · Updated 11 times

Summary

This early-phase trial tested a combination of two targeted drugs (palbociclib and binimetinib) in 34 people with advanced lung cancer that has a specific KRAS gene change. The main goal was to find the safest dose and check for early signs of tumor control. While not a cure, this approach aims to manage the disease in patients who have few other options.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

Conditions

Explore the condition pages connected to this study.