Double immunotherapy attack shows promise for tough lung cancer

NCT ID NCT04736173

Ongoing Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This phase 2 trial is testing a combination of two immunotherapy drugs, zimberelimab and domvanalimab, as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called PD-L1. The study includes 169 participants and aims to see if the combination helps keep the cancer from growing longer than standard treatments. Researchers are also checking overall survival, tumor shrinkage, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zimberelimab and domvanalimab (two immunotherapy drugs)
What this could lead to: If successful, this combination could offer a new first-line treatment option for people with advanced lung cancer that has high PD-L1 levels, potentially improving how long they live without their cancer worsening.
What could go wrong: This is a mid-stage trial with only 169 participants, so results may not apply to everyone. Immunotherapy can cause serious side effects like inflammation in healthy organs, and the combination may not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER NON-SMALL CELL LUNG CANCER NONSQUAMOUS NON SMALL CELL LUNG CANCER SQUAMOUS NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Research Site

Columbus, Georgia, 31904, United States
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Kingwood, Texas, 77339, United States
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Blacksburg, Virginia, 24060, United States
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Hong Kong, Hong Kong
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Johor Bahru, Malaysia
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Kuala Lumpur, Malaysia
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Kuantan, Malaysia
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Kuching, Malaysia
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Pulau Pinang, Malaysia
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Putrajaya, Malaysia
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Mexico City, Mexico
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San Luis Potosí City, Mexico
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Cebu, Philippines
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Davao City, Philippines
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Manila, Philippines
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Michalovce, Slovakia
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George, South Africa
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Johannesburg, South Africa
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Pretoria, South Africa
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Busan, South Korea
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Daegu, South Korea
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Incheon, South Korea
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Jinju, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Taichung, Taiwan
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Bangkok, Thailand
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Changwat Sara Buri, Thailand
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Chanthaburi, Thailand
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Chiang Mai, Thailand
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Khon Kaen, Thailand
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Lampang, Thailand
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Nakhon Nayok, Thailand
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Nakhon Ratchasima, Thailand
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Phitsanulok, Thailand
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Songkhla, Thailand
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Ubon Ratchathani, Thailand
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Edirne, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Kocaeli, Turkey (Türkiye)
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Hanoi, Vietnam
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Huế, Vietnam

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