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Engineered immune cells take aim at multiple Hard-to-Treat cancers

NCT ID NCT04348643

Terminated Disease control Sponsor: Chongqing Precision Biotech Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests a therapy called CEA CAR-T, which uses a patient's own immune cells modified to recognize and attack cancer cells that carry a protein called CEA. It is for adults aged 18-75 with advanced or recurrent solid tumors (such as lung, colorectal, liver, pancreatic, gastric, or breast cancer) that have not responded to standard treatments. The goal is to see if this cell therapy is safe and effective, and to find the best dose and schedule.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CEA CAR-T cells
What this could lead to
If successful, this could offer a new treatment option for several hard-to-treat cancers that express CEA, potentially shrinking tumors or slowing disease progression.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so the therapy may not work for everyone. CAR-T therapy can also cause serious side effects like cytokine release syndrome.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm colorectal cancer colorectal neoplasm gastric cancer gastric neoplasm liver cancer Liver Neoplasms lung cancer lung neoplasm malignant pancreatic neoplasm neoplasm pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER COLORECTAL CANCER GASTRIC CANCER LIVER CANCER LUNG CANCER PANCREATIC CANCER SOLID TUMOR

Contacts and locations

Locations

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, China

  • Henan Cancer Hospital

    Henan, China

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