New drug cocktail targets Hard-to-Treat cancers

NCT ID NCT06618287

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 5 times

Summary

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BMS-986507 (also called Iza-bren or Izalontamab brengitecan) combined with other drugs like osimertinib, pembrolizumab, nivolumab, or pumitamig
What this could lead to: If successful, this could point toward new treatment options for people with advanced lung or breast cancer that has not responded to other therapies.
What could go wrong: This is an early-phase trial (phase 1/2a) with a small number of participants, so the main goal is safety, not proof of effectiveness. The combinations may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm lung cancer lung neoplasm non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER LUNG CANCER

Contacts and locations

Locations

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
RECRUITING

Marseille, Bouches-du-Rhône, 13385, France
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy
CHUS - Hospital Clinico Universitario
RECRUITING

Santiago de Compostela, A Coruña [La Coruña], 15706, Spain
Centre Hospitalier de l'Université de Montréal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Centre Leon Berard
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cro-Irccs
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, Lombardy, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, 94800, France
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29011, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Madrid, Comunidad de, 28222, Spain
Hôpital Arnaud de Villeneuve - CHU Montpellier
RECRUITING

Montpellier, Hérault, 34090, France
Hôpital Tenon
RECRUITING

Paris, 75970, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
RECRUITING

Bordeaux, Aquitaine, 33076, France
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

Hospitalet, Barcelona [Barcelona], 08907, Spain
Institut Curie
RECRUITING

Paris, 75248, France
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
RECRUITING

Candiolo, Torino, 10060, Italy
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Leids Universitair Medisch Centrum
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Local Institution - 0001
NOT_YET_RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Local Institution - 0014
WITHDRAWN

Pittsburgh, Pennsylvania, 15232, United States
Local Institution - 0021
NOT_YET_RECRUITING

Glasgow, Glasgow City, G12 0YN, United Kingdom
Local Institution - 0023
WITHDRAWN

Ottawa, Ontario, K1H 8L6, Canada
Local Institution - 0047
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0048
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile
Local Institution - 0049
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8330032, Chile
Local Institution - 0052
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Local Institution - 0059
WITHDRAWN

Barcelona, Catalunya [Cataluña], 08036, Spain
Local Institution - 0064
NOT_YET_RECRUITING

Newmarket, Ontario, L3Y 2P9, Canada
Local Institution - 0065
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
Local Institution - 0076
WITHDRAWN

Caen, Calvados, 14076, France
Local Institution - 0077
WITHDRAWN

Nice, Alpes-Maritimes, 06189, France
Local Institution - 0101
NOT_YET_RECRUITING

Subiaco, Western Australia, 6008, Australia
Local Institution - 0102
NOT_YET_RECRUITING

Columbus, Ohio, 43212, United States
Local Institution - 0105
NOT_YET_RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile
Local Institution - 0107
NOT_YET_RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Local Institution - 0112
WITHDRAWN

Seville, 41009, Spain
Local Institution - 0118
WITHDRAWN

Valencia, Valenciana, Comunitat, 46010, Spain
Local Institution - 0127
WITHDRAWN

Madrid, 28040, Spain
NEXT Oncology - Irving
RECRUITING

Irving, Texas, 75039, United States
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
RECRUITING

Amsterdam, 1066 CX, Netherlands
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Royal Free Hospital
RECRUITING

London, England, NW32QG, United Kingdom
Swedish Medical Center
RECRUITING

Seattle, Washington, 98104, United States
The Ottawa Hospital - General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, West Midlands, B15 2GW, United Kingdom
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States

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