New drug cocktail targets Hard-to-Treat cancers

NCT ID NCT06618287

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BMS-986507 (also called Iza-bren or Izalontamab brengitecan) combined with other drugs like osimertinib, pembrolizumab, nivolumab, or pumitamig

What this could lead to

If successful, this could point toward new treatment options for people with advanced lung or breast cancer that has not responded to other therapies.

What could go wrong

This is an early-phase trial (phase 1/2a) with a small number of participants, so the main goal is safety, not proof of effectiveness. The combinations may cause side effects or fail to shrink tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm lung cancer lung neoplasm non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER LUNG CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
RECRUITING

Marseille, Bouches-du-Rhône, 13385, France

Contact Phone: •••-•••-••••
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy

Contact Phone: •••-•••-••••
CHUS - Hospital Clinico Universitario
RECRUITING

Santiago de Compostela, A Coruña [La Coruña], 15706, Spain

Contact
Centre Hospitalier de l'Université de Montréal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada

Contact Phone: •••-•••-••••
Centre Leon Berard
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France

Contact Phone: •••-•••-••••
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Phone: •••-•••-••••
Cro-Irccs
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy

Contact Phone: •••-•••-••••
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada

Contact Phone: •••-•••-••••
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, Lombardy, 20133, Italy

Contact Phone: •••-•••-••••
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy

Contact Phone: •••-•••-••••
Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, 94800, France

Contact Phone: •••-•••-••••
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29011, Spain

Contact Phone: •••-•••-••••
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [Barcelona], 08035, Spain

Contact Phone: •••-•••-••••
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain

Contact Phone: •••-•••-••••
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain

Contact
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Madrid, Comunidad de, 28222, Spain

Contact Phone: •••-•••-••••
Hôpital Arnaud de Villeneuve - CHU Montpellier
RECRUITING

Montpellier, Hérault, 34090, France

Contact Phone: •••-•••-••••
Hôpital Tenon
RECRUITING

Paris, 75970, France

Contact Phone: •••-•••-••••
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
RECRUITING

Bordeaux, Aquitaine, 33076, France

Contact Phone: •••-•••-••••
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

Hospitalet, Barcelona [Barcelona], 08907, Spain

Contact Phone: •••-•••-••••
Institut Curie
RECRUITING

Paris, 75248, France

Contact Phone: •••-•••-••••
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
RECRUITING

Candiolo, Torino, 10060, Italy

Contact Phone: •••-•••-••••
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada

Contact Phone: •••-•••-••••
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States

Contact Phone: •••-•••-••••
Leids Universitair Medisch Centrum
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands

Contact Phone: •••-•••-••••
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia

Contact Phone: •••-•••-••••
Local Institution - 0001
NOT_YET_RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

Contact
Local Institution - 0014
WITHDRAWN

Pittsburgh, Pennsylvania, 15232, United States
Local Institution - 0021
NOT_YET_RECRUITING

Glasgow, Glasgow City, G12 0YN, United Kingdom

Contact
Local Institution - 0023
WITHDRAWN

Ottawa, Ontario, K1H 8L6, Canada
Local Institution - 0047
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile

Contact
Local Institution - 0048
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile

Contact
Local Institution - 0049
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8330032, Chile

Contact
Local Institution - 0052
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States

Contact
Local Institution - 0059
WITHDRAWN

Barcelona, Catalunya [Cataluña], 08036, Spain
Local Institution - 0064
NOT_YET_RECRUITING

Newmarket, Ontario, L3Y 2P9, Canada

Contact
Local Institution - 0065
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States

Contact
Local Institution - 0076
NOT_YET_RECRUITING

Caen, Calvados, 14076, France

Contact
Local Institution - 0077
WITHDRAWN

Nice, Alpes-Maritimes, 06189, France
Local Institution - 0090
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States

Contact
Local Institution - 0093
NOT_YET_RECRUITING

Milan, 20141, Italy

Contact
Local Institution - 0101
NOT_YET_RECRUITING

Subiaco, Western Australia, 6008, Australia

Contact
Local Institution - 0102
NOT_YET_RECRUITING

Columbus, Ohio, 43212, United States

Contact
Local Institution - 0105
NOT_YET_RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile

Contact
Local Institution - 0107
NOT_YET_RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile

Contact
Local Institution - 0108
NOT_YET_RECRUITING

East Melbourne, Victoria, 3002, Australia

Contact
Local Institution - 0110
NOT_YET_RECRUITING

Ancona, 60126, Italy

Contact
Local Institution - 0112
NOT_YET_RECRUITING

Seville, 41009, Spain

Contact
Local Institution - 0118
NOT_YET_RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain

Contact
Local Institution - 0125
NOT_YET_RECRUITING

Maywood, Illinois, 60153, United States

Contact
Local Institution - 0127
NOT_YET_RECRUITING

Madrid, 28040, Spain

Contact
Local Institution - 0134
NOT_YET_RECRUITING

Portland, Oregon, 97225, United States

Contact
NEXT Oncology - Irving
RECRUITING

Irving, Texas, 75039, United States

Contact Phone: •••-•••-••••
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
RECRUITING

Amsterdam, 1066 CX, Netherlands

Contact Phone: •••-•••-••••
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia

Contact Phone: •••-•••-••••
Royal Free Hospital
RECRUITING

London, England, NW32QG, United Kingdom

Contact Phone: •••-•••-••••
Swedish Medical Center
RECRUITING

Seattle, Washington, 98104, United States

Contact Phone: •••-•••-••••
The Ottawa Hospital - General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

Contact Phone: •••-•••-••••
University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, West Midlands, B15 2GW, United Kingdom

Contact Phone: •••-•••-••••
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States

Contact Phone: •••-•••-••••
University of Miami Hospital and Clinics, Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

Contact Phone: •••-•••-••••
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States

Contact Phone: •••-•••-••••