Experimental combo aims to outsmart resistant lung cancer

NCT ID NCT05401110

Recruiting now Disease control Sponsor: Karen Reckamp, MD, MS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This early-phase trial tests whether adding carotuximab to the standard drug osimertinib is safe for people with advanced EGFR-mutated non-small cell lung cancer. About 60 participants whose cancer has progressed on prior treatments will receive both drugs. The main goal is to find the best dose and check for side effects, while also seeing if the combination can shrink tumors or delay progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Osimertinib and carotuximab
What this could lead to: If this works, it could offer a new treatment option for people with EGFR-mutated lung cancer whose current therapy stops working.
What could go wrong: This is a very early, small Phase 1 trial focused on safety, not yet proven to work. The combination may cause side effects or not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Cedars-Sinai Cancer at Beverly Hills (THO)
RECRUITING

Beverly Hills, California, 90211, United States
Cedars-Sinai Cancer at Hunt Cancer Center - TMPNCC
RECRUITING

Torrance, California, 90505, United States
Cedars-Sinai Cancer at SOCC
RECRUITING

Los Angeles, California, 90048, United States
Cedars-Sinai Cancer at The Angeles Clinic and Research Institute
RECRUITING

Los Angeles, California, 90025, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

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