Reading DNA clues: a blood test that could sniff out lung cancer

NCT ID NCT07008664

Recruiting now Diagnosis Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study is testing whether a blood test that looks for specific chemical changes on DNA can help diagnose lung cancer. Researchers will collect blood samples from 750 adults, including those with lung cancer, precancerous conditions, and healthy volunteers, and analyze the DNA for patterns that might signal cancer. The goal is to develop a simple, non-invasive tool that could catch lung cancer earlier and guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epigenetic Signature Assay (blood test measuring DNA methylation patterns)
What this could lead to: If successful, this blood test could offer a simpler, less invasive way to detect lung cancer early, potentially improving survival rates.
What could go wrong: This is an early-stage study focused on developing and validating the test, so it may not lead to a usable diagnostic tool. The test's accuracy and reliability are still being determined.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS (HV) LUNG CANCER LUNG CANCER SCREENING UNHEALTHY VOLUNTEERS

Contacts and locations

Locations

University of Maryland Baltimore Washington Medical Center
RECRUITING

Glen Burnie, Maryland, 21061, United States

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