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New study aims to predict lung cancer in Never-Smokers

NCT ID NCT05572944

Knowledge-focused Sponsor: Chung Shan Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is creating a risk prediction model for lung cancer in people who have never smoked. Researchers will enroll 10,000 participants aged 50-80 with a family history of lung cancer. They will collect data from questionnaires, blood tests for autoantibodies and genetic markers, and low-dose CT scans to identify high-risk individuals and improve early detection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a reliable way to identify never-smokers at high risk for lung cancer, enabling earlier detection and better outcomes.
What could go wrong
This is an observational study to develop a risk model, not a treatment trial. The model may not be accurate enough for widespread use, and results may not apply outside Taiwan.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Never-smoking population

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 50-80 years old 2. First-degree relatives of lung cancer patients * aged more than 50 - 80 years old * or older than the age at diagnosis of the youngest lung cancer the proband in the family if they are less than 50 years old Exclusion Criteria: 1. Previous history of lung cancer 2. Another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years 3. An inability to tolerate transthoracic procedures or thoracotomy 4. Chest CT examination was performed within 18 months 5. Hemoptysis of unknown etiology within one month 6. Body weight loss of more than 6 kg within one year without an evident cause 7. A known pregnancy

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chung Shan Medical University Hospital

    RECRUITING

    Taichung, Taiwan, 402, Taiwan

  • E-Da Hospital

    NOT_YET_RECRUITING

    Kaohsiung City, Taiwan

  • Hualien Tzu Chi Hospital

    RECRUITING

    Hualien City, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, Taiwan

  • Ministry of Health and Welfare Shuang-Ho Hospital

    NOT_YET_RECRUITING

    New Taipei City, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100229, Taiwan

  • National Taiwan University Hospital Hsin-Chu Branch

    RECRUITING

    Hsinchu, Taiwan

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