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Lung surgery without a breathing tube: a gentler path to recovery?

NCT ID NCT06574295

Disease control Sponsor: Fudan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether removing lung nodules with non-intubated video-assisted thoracic surgery, which avoids a breathing tube and ventilator, helps patients recover faster and feel better than traditional intubated surgery. Researchers will compare symptom burden, quality of life, and hospital stay length in about 876 adults aged 18 to 75 who need minimally invasive lung surgery. They will also assess the procedure's cost-effectiveness and patient preferences to guide broader adoption.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-intubated video-assisted thoracic surgery (VATS), a surgical procedure that removes lung nodules without using a breathing tube or mechanical ventilation
What this could lead to
If successful, this approach could become a standard option for lung nodule removal, offering faster recovery and fewer anesthesia-related complications.
What could go wrong
The trial is observational, so it cannot prove cause and effect. Results may vary by patient and hospital, and the procedure may not suit everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

876 people

The number who actually took part.

Started

Aug 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 18 to 75 years who have been diagnosed with pulmonary nodules or lung cancer and are scheduled for minimally invasive thoracic surgery. These patients will be divided into two groups: an experimental group undergoing non-intubated video-assisted thoracic surgery (VATS) and a control group undergoing intubated VATS. Both groups include individuals who are able to tolerate surgery based on preoperative evaluations, regardless of gender. All participants must provide informed consent and agree to complete the required follow-up assessments.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Experimental Group (Non-intubated Video-assisted Thoracic Surgery)： 1. Patients diagnosed with pulmonary nodules or lung cancer who are scheduled for minimally invasive surgery (including wedge resection, segmentectomy, or lobectomy). 2. Aged between 18 and 75 years, regardless of gender. 3. Preoperative assessment indicates that the patient can tolerate non-intubated video-assisted thoracic surgery. 4. The patient has signed an informed consent form and voluntarily agrees to participate in the study. Control Group (Intubated Video-assisted Thoracic Surgery)： 1. Patients diagnosed with pulmonary nodules or lung cancer who are scheduled for minimally invasive surgery (including wedge resection, segmentectomy, or lobectomy). 2. Aged between 18 and 75 years, regardless of gender. 3. Preoperative assessment indicates that the patient can tolerate minimally invasive surgery. 4. The patient has signed an informed consent form and voluntarily agrees to participate in the study. Exclusion Criteria: 1. Patients unable to provide sufficient preoperative and postoperative follow-up data. 2. Pregnant or breastfeeding women. 3. Patients with severe cardiopulmonary dysfunction preoperatively, making them unfit for surgery. 4. Patients who have previously undergone surgery or radiotherapy in the same chest region. 5. Patients with active infections or other severe comorbidities that may affect surgical outcomes. 6. Patients with mental illness or cognitive impairment who cannot understand the study content or comply with follow-up requirements.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer

Contacts and locations

Locations

  • Affiliated Hospital of Hebei University

    Baoding, Hebei, 071000, China

  • Affiliated Hospital of Jining Medical University

    Jining, Shandong, 272029, China

  • Anhui Chest Hospital

    Hefei, Anhui, 230022, China

  • Anning First People's Hospital

    Anning, Yunnan, 650300, China

  • Anyang Tumor Hospital

    Anyang, Henan, 455001, China

  • Binzhou Medical University Hospital

    Binzhou, Shandong, 256603, China

  • Cangzhou Central Hospital

    Cangzhou, Hebei, 061001, China

  • Chongqing General Hospital

    Chongqing, Chongqing Municipality, 401147, China

  • Deyang People's Hospital

    Deyang, Sichuan, 618000, China

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

  • Guangxi Zhuang Autonomous Region Nanxishan Hospital

    Guilin, Guangxi, 541002, China

  • Nanjing Drum Tower Hospital

    Nanjing, Jiangsu, 210008, China

  • School of Public Health, Fudan University

    Shanghai, Shanghai Municipality, 200032, China

  • Shaoxing People's Hospital

    Shaoxing, Zhejiang, 312000, China

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510120, China

  • The First Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830054, China

  • The First People's Hospital of Yunnan Province

    Kunming, Yunnan, 650032, China

  • The Second Affiliated Hospital of University of South China

    Hengyang, Hunan, 421001, China

  • The Second Hospital of Shandong University

    Jinan, Shandong, 250033, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China

  • Wuhan Central Hospital

    Wuhan, Hubei, 430014, China

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