New hope for Hard-to-Treat cancers: targeted combo trial opens
NCT ID NCT06922591
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 30 times
Summary
This study tests a new oral drug, TNG462, combined with other treatments for people with pancreatic or non-small cell lung cancer that has lost the MTAP gene and, in some cases, has a RAS mutation. The goal is to find safe doses and see if the combinations shrink tumors. About 183 adults with advanced or metastatic disease who have already tried standard therapy will participate.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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Georgetown University Medical Center
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Huntsman Cancer Institute, University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Cancer Center
RECRUITINGRochester, Minnesota, 55905-0001, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Scottsdale
RECRUITINGScottsdale, Arizona, 85259-5452, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 11065, United States
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NEXT Dallas
RECRUITINGIrving, Texas, 74039, United States
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NEXT Oncology
RECRUITINGFairfax, Virginia, 22031, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Nebraska Cancer Specialists
RECRUITINGOmaha, Nebraska, 68124, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611-2908, United States
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Sarah Cannon Research Institute Denver
RECRUITINGDenver, Colorado, 80218, United States
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University of Indiana
RECRUITINGIndianapolis, Indiana, 46202, United States
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599-7305, United States
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact
Conditions
Explore the condition pages connected to this study.