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New hope for hard-to-treat cancers: targeted combo trial opens

NCT ID NCT06922591

Recruiting now Disease control Sponsor: Tango Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new oral drug, TNG462, combined with other treatments for people with pancreatic or non-small cell lung cancer that has lost the MTAP gene and, in some cases, has a RAS mutation. The trial has two phases: first to find the safest dose, then to see how well the combination shrinks tumors. About 183 adults with advanced or metastatic disease who have already tried standard therapy will participate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic ductal adenocarcinoma thoracic cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER MTAP DELETION NSCLC PANCREATIC CANCER METASTATIC PDAC PDAC - PANCREATIC DUCTAL ADENOCARCINOMA RAS MUTATION THORACIC CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Georgetown University Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Huntsman Cancer Institute, University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Cancer Center

    RECRUITING

    Rochester, Minnesota, 55905-0001, United States

  • Mayo Clinic Jacksonville

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Scottsdale

    RECRUITING

    Scottsdale, Arizona, 85259-5452, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 11065, United States

  • NEXT Dallas

    RECRUITING

    Irving, Texas, 74039, United States

  • NEXT Oncology

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68124, United States

  • Northwestern Memorial Hospital

    RECRUITING

    Chicago, Illinois, 60611-2908, United States

  • Sarah Cannon Research Institute Denver

    RECRUITING

    Denver, Colorado, 80218, United States

  • University of Indiana

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • University of Iowa Health Care

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27599-7305, United States

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.