THORACIC CANCER

This study tests a new drug called TNG462, given with other cancer medicines, for people with pancreatic or lung cancer that has a specific genetic change (MTAP loss). The goal is to find safe doses and see if the combination shrinks tumors. About 183 adults with advanced cancer …

This study looks at whether proton therapy can safely treat tumors that have come back after standard radiation. Proton beams are more precise than X-rays, so they may deliver a stronger dose to the tumor while sparing healthy tissue. The study will enroll 1,800 adults with vario…

This study tests whether a special nerve block injection given before lung surgery can lower pain and the amount of pain medicine patients need afterward. About 70 adults having lung tumor removal will take part. Researchers will track pain scores and medication use for 24 hours …

This study is testing whether a virtual mind-body program called Integrative Medicine at Home (IM@Home) can help people with head and neck, thoracic, gynecologic, or other cancers feel less tired and have a better quality of life while receiving treatments like chemotherapy or ra…

This study is testing a new robotic system, the Medtronic Hugo™, for surgery on chest cancers. About 50 adults will have their tumor removal surgery using this robot. The goal is to see if the robot is safe and works well for these procedures.

This study is for people with lung or chest cancers that have come back or are new, and who have already had radiation before. Researchers want to see how safe and effective a second round of high-dose radiation is by tracking side effects and survival in 500 participants. The go…

This study looks at whether a simple test measuring heart and breathing patterns before major chest surgery can help predict complications after the operation. Researchers will enroll 130 adults undergoing surgery for lung, esophageal, or stomach cancer. The goal is to see if thi…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study is testing whether wearable devices like an Apple Watch and a home pulse oximeter can collect useful health information from 40 lung cancer patients during proton beam radiotherapy. Participants will wear the devices from the start of treatment until two weeks after it…

This study tests whether a patient navigator, text message check-ins, and an educational video can help more Black, Latinx, and older adults (70+) with advanced gastrointestinal, blood, or lung cancers get the genomic testing needed to join precision cancer trials. About 210 part…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatments than others, by looking at factors like genetics, lifestyle, and tumor details. The goal is to improve fu…