ENDOMETRIAL CANCER

This study tested a combination of three drugs (bevacizumab, atezolizumab, and rucaparib) in 30 people with endometrial cancer that had come back or continued to grow despite prior treatment. The goal was to see how many participants' tumors shrank or disappeared. The approach ai…

This study tested a drug called selinexor in 263 women with advanced or recurrent endometrial cancer who had finished chemotherapy and were in remission or partial remission. Participants took either selinexor or a placebo once a week to see if the drug could keep the cancer from…

This early-phase trial tested a new drug called TPST-1495, given alone or with pembrolizumab, in 89 people with advanced solid tumors (like colorectal, lung, or head and neck cancers) that had stopped responding to standard treatments. The main goal was to find a safe dose and ch…

This study tested a high-dose internal radiation therapy (brachytherapy) in 43 adults with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver the right dose. Participants received the…

This study tested a combination of three drugs (afuresertib, sintilimab, and chemotherapy) in 22 adults with certain solid tumors that had stopped responding to prior immunotherapy. The goal was to find the safest dose and see if the combo could shrink tumors. The approach aims t…

This study looked at whether high-intensity interval training (short bursts of intense exercise) before standard surgery could slow the growth of endometrial cancer in 30 women. Participants exercised in supervised sessions, and researchers checked tissue samples for changes in c…

This study tested an experimental drug combination (MK-4280A) in 163 people with either a type of skin cancer (cutaneous squamous cell carcinoma) or endometrial cancer. The goal was to see if the treatment could shrink or eliminate tumors. Participants received either the new com…

This study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had run out of standard options. The main goals were to check safety, find the best dose, and see if the drug shrinks tumors. It is an early-phase tria…

This study tested a shorter course of pelvic radiation (about 1 week instead of the usual 5-6 weeks) given after hysterectomy for advanced endometrial cancer. The goal was to see if this shorter treatment causes fewer side effects while still controlling the cancer. The study inc…

This study tested a shorter course of pelvic radiation for women with endometrial cancer after surgery. The goal was to see if this approach is safe and tolerable. Eight patients participated, and researchers monitored side effects and quality of life for three months after treat…

This study looked at whether adding a drug called aprepitant to the usual two anti-nausea medicines can better prevent vomiting and nausea caused by chemotherapy in women with gynecologic cancers like ovarian or cervical cancer. 143 women took part. The goal was to see if the thr…

This study looked at whether a drug called oliceridine is safe and effective for putting patients to sleep during gynecologic laparoscopic surgery for endometrial cancer. Researchers compared it to another drug, sufentanil, by checking blood pressure and heart rate changes. The s…

This study tested a new way to follow up with people who finished treatment for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor every time, patients met with a nurse every other visit and used a smartphone app to help manage t…

This study tested a physical activity program for breast and endometrial cancer survivors who were not getting enough exercise. The program used technology like fitness trackers and electronic health records to provide support, with extra help for those who needed it most. The go…

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health and fitness in women who finished treatment for endometrial cancer. Thirty-three survivors in remission took part. They received exercise equipment and a Fitbit, and had he…

This study tested a home-based, personalized brain training program for 60 women with gynecologic cancer (ovarian, endometrial, cervical, or vulvar) who had finished chemotherapy and reported memory or thinking issues. The goal was to see if the program was practical and acceptab…

This study looked at 78 women having hysterectomy or related surgery to compare robotic-assisted laparoscopy with conventional laparoscopy. The main goal was to see how long each type of surgery takes. Researchers also tracked time under anesthesia, blood loss, and other details …

This study measured 14 trace elements (like iron, selenium, lead) in blood samples from 40 women: some with endometriosis, some with ovarian or endometrial cancer, and healthy controls. Researchers wanted to see if certain elements are higher or lower in each disease group. The g…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used data from past clinical trials and real-world medical records to compare outcomes in …

This study looked at 150 women with intermediate- or high-risk endometrial cancer to compare two types of surgery: removing lymph nodes from the lower part of the abdomen versus removing nodes from both the lower and upper abdomen. The goal was to see which approach gives doctors…

This study looked at how chemotherapy affects the overall quality of life in women treated for stage II or III endometrial cancer. Researchers surveyed 51 women at least two years after their treatment ended, using standard questionnaires to measure physical, emotional, and socia…

This study reviewed medical records of 509 adults in Taiwan with advanced cervical, endometrial, or ovarian cancer. Researchers wanted to find out how many of these cancers have high levels of a protein called HER2, which can help guide treatment. The goal is to better understand…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study observed 102 women with ovarian, fallopian tube, or endometrial cancer who received standard chemotherapy (carboplatin and paclitaxel). Researchers measured changes in taste, muscle mass, and nutrition before, during, and after treatment. The goal was to understand how…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study tested a newer, more precise type of radiation therapy for people with endometrial or cervical cancer after surgery. The goal was to find the smallest safe radiation target area to reduce side effects while still covering the cancer. Fifteen patients participated, and …

This study tested a new type of follow-up clinic for women who finished treatment for early-stage breast or gynecologic cancer. The clinic used online surveys to track symptoms and connect patients with nurses or dietitians when needed. The goal was to see if this approach was pr…

This study looked at 66 women having hysterectomy (removal of the uterus) to compare a newer method called vNOTES (done through the vagina) with standard laparoscopic surgery. The goal was to see which approach causes less pressure inside the head, measured by ultrasound of the o…

This study tested a new way to inject a green dye to find lymph nodes during robotic surgery for early-stage endometrial cancer. The new method injects the dye until the surgeon can see the lymph channels in real time, while the standard method uses a fixed amount. The goal was t…