New pill aims to keep endometrial cancer at bay after chemo

NCT ID NCT03555422

Completed Disease control Sponsor: Karyopharm Therapeutics Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested whether taking the drug selinexor as a maintenance pill after chemotherapy can help delay cancer progression in people with advanced or recurrent endometrial cancer. 263 participants who had responded to initial chemo were randomly assigned to receive either selinexor or a placebo. The study is now complete, and researchers are analyzing how long participants remained cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: selinexor (a drug taken as a pill)
What this could lead to: If it works, this could offer a new maintenance option to delay cancer progression after initial chemotherapy for advanced or recurrent endometrial cancer.
What could go wrong: This is a completed Phase 3 trial, but results are not yet widely available. Selinexor may cause side effects like nausea, fatigue, or low blood counts, and it may not improve survival for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrium neoplasm Genital Diseases neoplasm Neoplasms by Site uterine cancer uterine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER

Contacts and locations

Locations

ALEXANDRA Hospital

Athens, Greece, 11528, Greece
AZ Turnhout

Turnhout, 2300, Belgium
Agostino Gemelli University Polyclinic Foundation

Rome, 30161, Italy
Arizona Oncology

Tucson, Arizona, 85711, United States
CHR Verviers

Verviers, 4800, Belgium
CHU UCL Namur, Site Sainte-Elisabeth

Namur, 5000, Belgium
Cartitas Klinikum Saarbrücken

Saarbrücken, 66113, Germany
Charite Berlin Universitatsmedizin

Berlin, 13353, Germany
Chongqing University Cancer Hospital

Chongqing, Shapingba District, 400000, China
Consorci Sanitari de Terrassa

Barcelona, 08227, Spain
DIAKOVERE KH gGmbH, Henriettenstift Hannover

Hanover, 30171, Germany
Euromedica General Clinic

Thessaloniki, Macedonia, 54645, Greece
Florida Cancer Specialists (Sarah Cannon Research Institute)

West Palm Beach, Florida, 33401, United States
General University Hospital in Prague

Prague, 12851, Czechia
Gynecological Cancer Institute of Chicago

Oak Lawn, Illinois, 60453, United States
HCA Midwest Health - Kansas City (Sarah Cannon Research Institute)

Kansas City, Missouri, 64132, United States
Hadassah Medical Center

Jerusalem, 9112001, Israel
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150040, China
Henan Cancer Hospital

Zhengzhou, Henan, China
Hillel Yaffe Medical Center

Hadera, 38100, Israel
Hospital Clínico Universitario Lozano Blesa

Zaragoza, 50009, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital Na Bulovce

Prague, 18081, Czechia
Hospital Son Llàtzer

Palma, 071998, Spain
Hospital Universitari Clínic de Barcelona

Barcelona, 08036, Spain
Hospital Universitari Vall d' Hebrón

Barcelona, 08035, Spain
Hospital Universitario Donostia

San Sebastián, Gipuzkoa, 20014, Spain
Hospital Universitario Infanta Sofía

Madrid, 28702, Spain
Hospital Universitario Puerta de Hierro - Majadahonda

Madrid, 28220, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocío

Seville, 41013, Spain
Hospital Universitario y Politécnico de La Fe

Valencia, 46026, Spain
Hunan Cancer Hospital

Changsha, Hunan, China
Iaso Hospital

Marousi, Athens, 151 23, Greece
Indiana University Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Instituto Valenciano de Oncología

Valencia, 46009, Spain
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica

Naples, 80131, Italy
Istituto Nazionale dei Tumori IRCCS - MILANO S.C. Ginecologia Oncologica

Milan, 20133, Italy
Istituto di Candiolo, FPO, IRCCS

Candiolo, 10060, Italy
Jan Yperman Ziekenhuis

Ieper, 8900, Belgium
Jiangxi Maternal and Child Health Hospital

Nanchang, Jiangxi, 330006, China
Klinikum der Universitat Munchen

Munich, 80337, Germany
Liaoning Cancer Hospital

Shenyang, Liaoning, 110042, China
London Health Sciences Centre (London Regional Cancer Centre)

London, Ontario, N6C 0A7, Canada
McGill University Health Centre (MUHC)

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
NYU Langone

New York, New York, 10016, United States
Oncology Associates of Oregon

Eugene, Oregon, 97401, United States
Parkview Research Center

Fort Wayne, Indiana, 46845, United States
Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China
Romagnolo Scientific Institute for the Study and Treatment of Tumors

Meldola, 47014, Italy
San Raffaele Hospital

Milan, 20132, Italy
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Sheba Medical Center

Ramat Gan, 52621, Israel
Stanford University

Palo Alto, California, 94304, United States
Tennessee Oncology Nashville (Sarah Cannon Research Institute)

Nashville, Tennessee, 37203, United States
Texas Oncology DFW

Dallas, Texas, 75246, United States
Texas Oncology DFW

Fort Worth, Texas, 76104, United States
Texas Oncology, Austin

Austin, Texas, 78731, United States
UH Královské Vinohrady

Prague, 10034, Czechia
ULSS 3 SERENISSIMA UOC Oncologia Ed Ematologia Oncologica

Mirano, 30174, Italy
UZ Gent

Ghent, 9000, Belgium
Universitaire Ziekenhuizen K.U. Leuven

Leuven, 3000, Belgium
Universitatsklinikum Schleswig-Holstein

Kiel, 24105, Germany
University Health Network (PMCC)

Toronto, Ontario, M5G 2M9, Canada
University Hospital Brno

Brno, 60200, Czechia
University Hospital Dresden

Dresden, 01307, Germany
University Hospital Ostrava

Ostrava, 70852, Czechia
University of Oklahoma Health Sciences Center - Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Universitätsfrauenklinik Mainz

Mainz, 55131, Germany
Universitätsfrauenklinik Ulm

Ulm, 89070, Germany
VCU Massey Cancer Center

Richmond, Virginia, 23298, United States
Virgen de la Arrixaca University Clinical Hospital

Murcia, 30120, Spain
Wenzhou Medical University - The First Affiliated Hospital

Wenzhou, Zhejiang, 325000, China
Wolfson Medical Center

Holon, 58100, Israel
Women & Infants Hospital of Rhode Island

Providence, Rhode Island, 02905, United States

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