Karyopharm Therapeutics Inc

This study is testing an oral medication called selinexor for adults with an aggressive type of blood cancer (diffuse large B-cell lymphoma) that has come back or stopped responding to at least two prior treatments. The main goal is to see if the drug can shrink the cancer and fo…

This study is testing 12 different combinations of an experimental drug called selinexor with other approved myeloma medications. It aims to find safe and effective treatment options for adults whose multiple myeloma has returned after prior therapy or who are newly diagnosed. Th…

This study is testing whether adding a new drug called selinexor to standard chemotherapy works better for people with aggressive lymphoma that has returned or stopped responding to previous treatments. The trial will involve about 500 patients who cannot receive stem cell transp…

This program provides the investigational drug selinexor to patients with certain cancers who have run out of standard treatment options and don't qualify for ongoing clinical trials. It allows doctors to request the drug for eligible patients before it receives full regulatory a…

This study is testing if a pill called selinexor can help keep advanced or recurrent endometrial cancer from coming back after successful chemotherapy. It will involve 276 adults whose cancer responded well to initial treatment. Participants will be randomly assigned to take eith…

This study is testing two different drug combinations for people with multiple myeloma that has stopped responding to multiple standard treatments. Researchers want to see if adding a new drug called selinexor to existing medications can help control the cancer. The trial is enro…

This study is testing whether the drug selinexor can reduce spleen size and ease symptoms in people with myelofibrosis, a type of bone marrow cancer, who also have low platelet counts and have not yet taken common JAK inhibitor drugs. About 58 participants will take selinexor alo…