New combo therapy shows promise for Hard-to-Treat myeloma

NCT ID NCT02343042

First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 26 times

Summary

This study tests a drug called selinexor combined with other standard treatments for multiple myeloma, a type of blood cancer. It includes 300 adults with either newly diagnosed or relapsed/refractory disease. The goal is to find safe doses and see how well the combinations control the cancer, but patients will need ongoing therapy.

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Contacts and locations

Locations

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234, United States

  • Cancer Care Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Columbia University

    New York, New York, 10032, United States

  • Cross Cancer Institute / University of Alberta

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke Institute of Cancer/ Duke University

    Durham, North Carolina, 27710, United States

  • Fred Hutch Cancer Center

    Seattle, Washington, 98109, United States

  • Hackensack University Medical Center - John Theurer Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Jonnsson Comprehensive Cancer Center / University of Los Angeles

    Los Angeles, California, 0095, United States

  • Maisonneuve-Rosemont Hospital

    Montreal, Quebec, H1T 2M4, Canada

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Hospital of Newfoundland

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Queen Elizabeth II Health Sciences Center

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Royal Victoria Hospital / McGill University

    Montreal, Quebec, H3A 1A1, Canada

  • Sarah Cannon- Tennessee Oncology Nashville

    Nashville, Tennessee, 37203, United States

  • Swedish Cancer Institute

    Seattle, Washington, 98109, United States

  • Tom Baker Cancer Center/Alberta Health Services

    Calgary, Alberta, T2N 4Z6, Canada

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of North Carolina - Chapel Hill Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Wisconsin School of Medicine and Public Health

    Madison, Wisconsin, 53792, United States

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Weill Cornell Medicine

    New York, New York, 10065, United States

  • Wilmot Cancer Center/ University of Rochester

    Rochester, New York, United States

Conditions

Explore the condition pages connected to this study.