Karyopharm Therapeutics Inc

This study is testing whether adding a new drug called selinexor to an existing standard drug (ruxolitinib) works better for people newly diagnosed with myelofibrosis, a serious bone marrow cancer. The main goals are to see if the combination shrinks enlarged spleens more effecti…

This study aimed to test the safety and effectiveness of a drug called selinexor when combined with other treatments for adults with an aggressive type of blood cancer (DLBCL) that has returned or stopped responding to prior therapies. The first part of the study would find the s…

This study is testing an oral drug called selinexor for people with myelofibrosis, a serious bone marrow cancer, who have already tried and stopped responding to standard JAK inhibitor treatments. About 112 participants will be randomly assigned to receive either selinexor or the…