New hope for aggressive lymphoma patients with no other options

NCT ID NCT02227251

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 32 times

Summary

This study tests an experimental drug called selinexor in adults with relapsed or refractory diffuse large B-cell lymphoma (a type of blood cancer) who have run out of standard treatments. The main goal is to see how many patients respond to the drug. About 244 participants will take selinexor pills, and researchers will track tumor shrinkage and side effects.

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Contacts and locations

Locations

  • AOU Maggiore della Carità SCDU Ematologia

    Florence, Italy

  • AZ Delta

    Roeselare, Belgium

  • AZ Sint-Jan

    Bruges, 8000, Belgium

  • Addenbrooke's Hospital Cambridge

    Cambridge, CB2 0QQ, United Kingdom

  • Akh Linz Innere Med III - Zentrum für Hämatologie und med. Onkologie

    Linz, Austria

  • Ashford Cancer Centre

    Kurralta Park, South Australia, 5037, Australia

  • Assuta Medical Center

    Tel Aviv, 69710, Israel

  • Azienda Ospedaliero-Universitaria Senese

    Siena, Italy

  • Boca Raton Cancer Research Medical Center

    Plantation, Florida, United States

  • CH Jolimont

    La Louvière, 7100, Belgium

  • CHRU de Lille - Hopital Claude-Huriez

    Lille, France

  • CHU Lyon Sud

    Pierre-Bénite, Lyon, France

  • CHU Montpellier

    Montpellier, France

  • CSolnoky ferenc Hospital

    Veszprém, Hungary

  • Calvary Mater Newcastle Hospital

    Waratah, New South Wales, 2298, Australia

  • Cancer Institute (WIA)

    Chennai, Tamil Nadu, 600020, India

  • Centre Henri Becquerel

    Rouen, France

  • Centre Hospitalier Universitaire Henri Mondor

    Créteil, France

  • Centrum Onkologii- Insytut Im. Marii Skłodowskiej-Curie Klinika Nowotworow Ukladu Chlonnego

    Warsaw, 02-781, Poland

  • Charite Universitatsmedizin Berlin (Benjamin Franklin Campus)

    Berlin, Germany

  • Charite Universitatsmedizin Berlin (Virchow Campus)

    Berlin, Germany

  • Christchurch Hospital

    Christchurch, 8001, New Zealand

  • Chu Dijon-Bourgogne - Hematologie Clinique

    Dijon, France

  • Città della Salute e della Scienza di Torino

    Torino, Italy

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Clinical Research Alliance

    Lake Success, New York, United States

  • Cliniques Universitaires Saint-Luc

    Brussels, Belgium

  • Clínica Universidad De Navarra

    Pamplona, Spain

  • Dana Farber Cancer Institute

    Boston, Massachusetts, United States

  • Dayanand Medical College and Hospital

    Ludhiana, Punjab, 160012, India

  • Deenanath Mangeshkar Hospital

    Pune, Maharashtra, 411004, India

  • Department of clinical hematology ,university hospital Ioannina

    Ioannina, 45110, Greece

  • Derriford Hospital

    Plymouth, PL6 8DH, United Kingdom

  • Dr. B.R.A. Institute Rotary Cancer Hospital All India Institute of Medical Sciences

    New Delhi, 110029, India

  • Epworth Hospital

    East Melbourne, Victoria, 3001, Australia

  • Ev. Diakonie-Krankenhaus gGmbH

    Bremen, 28239, Germany

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Fondazione Policlinico Universitario A. Gemelli

    Rome, Italy

  • G. Kuppu Swamy Naidu Hospital

    Coimbatore, Tamil Nadu, 641037, India

  • Gabrail Cancer Center

    Canton, Ohio, 44718, United States

  • Gemeinschaftspraxis Haematologie and Onkologie-Dresden

    Dresden, 01307, Germany

  • Gloucestershire Royal Hospital

    Gloucester, Gloucestershire, GL1 3NN, United Kingdom

  • Greenville Hospital System

    Greenville, South Carolina, 29605, United States

  • Guy's and St Thomas' NHS Foundation Trust

    London, United Kingdom

  • H-Hartziekenhuis Roeselare-Menen

    Roeselare, Belgium

  • HELIOS Klinikum Bad Saarow

    Bad Saarow, Germany

  • Hadassah Medical Center

    Jerusalem, Israel

  • Haematology Department and HCT Unit G.Papanicolaou Hospital

    Exochi, Thessaloniki, Greece

  • Hematology Clinic,General Hospital of Athens,G. Gennimatos

    Athens, 11527, Greece

  • Hematology Department Laiko General Hospital

    Athens, Greece

  • Hematology Department St John's Cancer Centre

    Lublin, Poland

  • Hematology-Oncology & Stem Cell Transplantation Unit, National Cancer Institute, Fondazione 'G. Pascale', IRCCS

    Naples, 80131, Italy

  • Hematology-Soroka

    Beersheba, Israel

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Spain

  • Hospital Universitario La Paz

    Madrid, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital University Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital de Son Llàtzer

    Palma de Mallorca, Spain

  • Hospitalier de la Rochelle-Ré-Aunis

    La Rochelle, France

  • Hospitla Universitari Germans Trias i Pujol - ICO

    Badalona, 8916, Spain

  • Hostpial Saint Louis - CIRCO (Centre d'Investigations et de Recherche Clinique en Oncologie)

    Paris, 75010, France

  • Hôpital Necker Service d'Hématologie Adult

    Paris, France

  • IRCH, All India Institute of Medical Sciences

    Delhi, India, 110029, India

  • Icon Cancer Care

    South Brisbane, Queensland, 4101, Australia

  • Institut Jules Bordet

    Brussels, 1000, Belgium

  • Institut za onkologiju Vojvodine

    Kamenitz, 21204, Serbia

  • Institut za onkologiju i radiologiju Srbije

    Belgrade, 11000, Serbia

  • Institute of Medical Sciences & SUM Hospital

    Bhubaneswar, Odisha, 751003, India

  • Instituto di Ematologia Seragnoli Pad 8 Universita di Bologna

    Bologna, Italy

  • Instytut Hematologii i Transfuzjologii

    Warsaw, 02-776, Poland

  • Jaslok Hospital and Research Centre

    Mumbai, Maharashtra, 400026, India

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, United States

  • King George's Medical University (KGMU)

    Lucknow, Uttar Pradesh, 226003, India

  • King's College Hospital

    London, SE5 9RS, United Kingdom

  • Klinicko Bolnick Centar Zemun Odeljenje hematologije

    Belgrade, 11000, Serbia

  • Klinikum Kempten Klinik für Innere Medizin III - Hämatologie, Onkologie und Palliativmedizin

    Cologne, Germany

  • Klinikum Leverkusen

    Leverkusen, Germany

  • Klinikum Ludwigshafen

    Ludwigshafen, Germany

  • Klinikum Nürnberg Nord

    Nuremberg, 90419, Germany

  • Klinički centar Niš Klinika za hematologiju

    Niš, 18000, Serbia

  • Klinički centar Srbije Klinika za hematologiju

    Belgrade, 11000, Serbia

  • Kliničko bolnički centar Zvezdara

    Belgrade, 11000, Serbia

  • Krankenhaus Barmherzigen Schwestern Linz

    Linz, Austria

  • Krankenhaus der Elisabethinen Linz GmbH

    Linz, Austria

  • LKH Leoben Department for Haemato-Oncology

    Leoben, 8700, Austria

  • LUMC (leidse universitair medisch centrum)

    Leiden, Netherlands

  • Lahey Clinic

    Burlington, Massachusetts, United States

  • Leeds Teaching Hospitals NHS Trust

    Leeds, Yorkshire, United Kingdom

  • Liverpool Hospital, Ingham Institute of Medical Research

    Liverpool, New South Wales, 2170, Australia

  • MCM (Małopolskie Centrum Medyczne)

    Krakow, 30-510, Poland

  • MD Anderson

    Houston, Texas, 77030, United States

  • Maria Sklodowska Curie National Research Institute

    Warsaw, Poland

  • Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes

    Marseille, France

  • Martin-Luther-University Halle-Wittenberg Department of Oncology

    Halle, Germany

  • Medical University of Graz

    Graz, 8036, Austria

  • Medical University of Vienna (MUW) Department of Medicine I

    Vienna, Austria

  • Medizinische Hochschule

    Hanover, Germany

  • Medizinische Universität Innsbruck für Innere Medizin

    Innsbruck, Austria

  • Meenakshi Mission Hospital & Research Centre

    Madurai, Tamil Nadu, 625107, India

  • Memorial Provincial Specialist Hospital in Lodz

    Lodz, 62-1010, Poland

  • Monash Medical Centre

    Clayton, Victoria, 3168, Australia

  • National & Kapodistrian University of Athens, Attiko University Hospital

    Chaïdári, 12462, Greece

  • National & Kapodistrian University of Athens, Laiko General Hospital

    Athens, 11527, Greece

  • Netaji Subhas Chandra Bose Cancer Research Hospital

    Kolkata, West Bengal, 700094, India

  • Netaji Subhas Chandra Bose Cancer Research Institute

    Kolkata, West Bengal, 70016, India

  • New York Presbyterian Hospital/ Cornell Medical College

    New York, New York, 10065, United States

  • Nil Ratan Sircar Medical College and Hospital

    Kolkata, West Bengal, 700014, India

  • North Shore Hospital

    Auckland, 0622, New Zealand

  • Northwick Park Hospital

    Harrow, Middlesex, HA1 3UJ, United Kingdom

  • Norton Cancer Institute

    Louisville, Kentucky, 40241, United States

  • Országos Onkológiai Intézet "A" Belgyógyászati Onkológiai Osztály

    Budapest, 1122, Hungary

  • Oxford University Hospitals NHS Trust Oxford Cancer and Haematology Centre, Churchill Hospital

    Oxford, OX3 7LE, United Kingdom

  • Pitié-Salpêtrière Hospital

    Paris, France

  • Prince Aly Khan Hospital

    Mumbai, Maharashtra, 400010, India

  • Princess Margaret Cancer Centre

    Toronto, Ontario, Canada

  • Princess Royal University Hospital (PRUH)

    London, SE5 9RS, United Kingdom

  • Pécsi Tudományegyetem, ÁOK, I. számú Belgyógyászati Klinika

    Pécs, Hungary

  • Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Rajiv Gandhi Cancer Hospital

    New Delhi, National Capital Territory of Delhi, 110085, India

  • Rambam Healthcare Campus

    Haifa, Israel

  • Regional Cancer Centre

    Thiruvananthapuram, Kerala, 695011, India

  • Regional Cancer Centre, IGIMS

    Patna, Bihar, 800014, India

  • Robert H. Lurie Comprehensive Cancer Center/Northwestern University

    Chicago, Illinois, United States

  • Rotkreuzklinikum München

    München, Germany

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Liverpool University Hospital

    Liverpool, United Kingdom

  • Royal Marsden Hospital

    Sutton, London, SM2 5PT, United Kingdom

  • SCDU Ematologia, Division of Hematology, Dept. of Translational Medicine, Universita del Piemonte Orientale

    Novara, 28100, Italy

  • SODc Ematologica ,AOU Careggi

    Florence, 50134, Italy

  • SRM Institutes for Medical Science

    Vadapalani, Chennai, 600026, India

  • Samodzielny Publiczny Zakład Opieki Zdrowotnej Ministerstwa

    Olsztyn, 10-228, Poland

  • Saveetha Medical College Hospital

    Chennai, Tamil Nadu, 602105, India

  • Second Depth of Internal Medicine, Attiko University Hospital

    Athens, Greece

  • Semmelweis Egyetem Általános Orvosi Kar

    Budapest, 1083, Hungary

  • Semmelweis University Department of Medicine and Oncology

    Budapest, Hungary

  • Sheba Medical Center

    Tel Litwinsky, Israel

  • Sir Mortimer B Davis Jewish General Hospital/McGill University

    Montreal, Quebec, Canada

  • Somogy Megyei Kaposi Mór Oktató Kórház

    Kaposvár, 7400, Hungary

  • Southampton University Hospital

    Southampton, Hampshire, SO16 6YD, United Kingdom

  • Specialized Hospital for Active Treatment of Haematological Diseases EAD

    Sofia, 1756, Bulgaria

  • St. Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010, Australia

  • St. Vincent's Melbourne

    Fitzroy, Victoria, 3065, Australia

  • Stony Brook University Hospital

    Stony Brook, New York, 11794, United States

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Szpitale Wojewódzkie w Gdyni, Gdyńskie Centrum onkologii

    Gdynia, 81-519, Poland

  • TATA Memorial Centre

    Kolkata, West Bengal, 700156, India

  • TLV Sorasky Medical Center

    Tel Aviv, Israel

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The Clatterbridge Cancer Centre NHS Foundation Trust

    Liverpool, United Kingdom

  • Tufts Medical Center

    Boston, Massachusetts, United States

  • UACC Arizona

    Tucson, Arizona, 85704, United States

  • UZ Gent

    Ghent, 9000, Belgium

  • Uni. Klinik für Innere Medizin III Universitätsklinikum der PMU LKH Salzburg

    Salzburg, A-5020, Austria

  • Uniklinik Aachen Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation

    Aachen, Germany

  • Unite Hemopathies Lymphoides Chu Henri Mondor

    Créteil, France

  • Univ. General Hospital Hietzing

    Vienna, Austria

  • University Hospital for Active Treatment Dr. Georgi Stranski

    Pleven, 5800, Bulgaria

  • University Hospitals Seidman Cancer Center

    Cleveland, Ohio, United States

  • University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD

    Sofia, 1431, Bulgaria

  • University of California Los Angeles (UCLA)

    Santa Monica, California, 90404, United States

  • University of California San Francisco

    San Francisco, California, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Massachusetts Medical School

    Worcester, Massachusetts, United States

  • University of Oklahoma

    Oklahoma City, Oklahoma, United States

  • University of Patras Medical School

    Pátrai, 26504, Greece

  • Universität Heidelberg Medizinische Klinik V Hämatologie, Onkologie und Rheumatologie

    Heidelberg, Germany

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza

    Wroclaw, Radeckiego, 50-367, Poland

  • VUMc (Vrije Universiteit Amsterdam)

    Amsterdam, 1081 HV, Netherlands

  • Veszprém Megyei Csolnoky Ferenc Kórház

    Veszprém, 8200, Hungary

  • Virginia Mason Hospital & Medical Center

    Seattle, Washington, United States

  • Wojewodzki Szpital Specjalistyczny w Legnicy

    Legnica, 59-220, Poland

  • Wolfson MC

    Holon, Israel

  • Ziekenhuis Netwerk Antwerpen

    Antwerp, Belgium

Conditions

Explore the condition pages connected to this study.