Karyopharm Therapeutics Inc

This program provides early access to the investigational drug selinexor for people with multiple myeloma, lymphoma, sarcoma, or other cancers who have exhausted all approved treatments and cannot join a clinical trial. Patients must get approval from their doctor and local healt…

This study tests a drug called selinexor in people with myelofibrosis who have low platelet counts and have not yet taken JAK inhibitors. The main goal is to see if the drug can shrink the spleen by at least 35% after 24 weeks. About 58 adults will take selinexor alone, and resea…

This study tests a drug called selinexor combined with low-dose dexamethasone (and sometimes bortezomib) in people with multiple myeloma that has stopped responding to many other treatments. The goal is to see if these combinations can shrink tumors and control the disease. About…

This study tests whether taking selinexor pills after standard chemotherapy can delay cancer growth in people with a specific type of advanced or recurrent endometrial cancer (p53 wild-type). About 276 adults whose cancer shrank or disappeared after at least 12 weeks of platinum-…