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New hope for patients with advanced multiple myeloma: drug combo shows promise

NCT ID NCT04414475

Recruiting now Disease control Sponsor: Karyopharm Therapeutics Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called selinexor combined with a low-dose steroid (dexamethasone) in people with multiple myeloma that has stopped responding to many other treatments. Some participants will also receive another drug, bortezomib. The goal is to see if these combinations can shrink tumors and control the disease. About 127 adults aged 18 and older with specific types of refractory myeloma will take part.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA REFRACTORY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Assuta Ashdod Medical Center

    RECRUITING

    Ashdod, Ashdod, 7747629, Israel

  • Barzilai Medical Center

    RECRUITING

    Ashkelon, 7830604, Israel

  • Bnai-Zion Medical Center

    RECRUITING

    Haifa, Haifa District, 3108, Israel

  • Emek Medical Center

    RECRUITING

    Afula, Afula, 1834111, Israel

  • General Hospital of Athens "Alexandra"

    RECRUITING

    Attiki, Athens, 11528, Greece

  • General Hospital of Athens "Evangelismos"

    RECRUITING

    Athens, Attica, 10676, Greece

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, Jerusalem, 9112001, Israel

  • Meir Medical Center

    COMPLETED

    Kfar Saba, 4428164, Israel

  • Rabin Medical Center (Beilinson Hospital)

    RECRUITING

    Petah Tikva, Petah Tikva, 49100, Israel

  • Rambam Health Care Campus

    RECRUITING

    Haifa, Haifa District, 3109601, Israel

  • Shaare Zedek Medical Center

    RECRUITING

    Jerusalem, Jerusalem, 9103102, Israel

  • Soroka University Medical Center

    ACTIVE_NOT_RECRUITING

    Beersheba, Israel

  • Tel Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, Tel Aviv, 64239, Israel

  • The Chaim Sheba Medical Center at Tel HaShomer

    RECRUITING

    Ramat Gan, Ramat Gan, 52621, Israel

  • Theageneion Cancer Hospital

    RECRUITING

    Thessaloniki, Thessaloniki, 54007, Greece

  • University General Hospital of Patras

    COMPLETED

    Pátrai, Achaia, 2654, Greece

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