ENDOMETRIAL CANCER

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after previous treatments like immunotherapy. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive treatment…

This study tests whether a newer, daily-adapted radiation technique can safely deliver fewer, stronger radiation doses for several pelvic cancers (prostate, endometrial, cervical, and rectal). About 264 participants will be randomly assigned to either standard radiation or the sh…

This study tests a new experimental drug (PF-08634404) combined with chemotherapy against an approved drug (pembrolizumab) plus chemotherapy in about 600 women with advanced or recurrent endometrial cancer that has a working DNA repair system (pMMR). Participants are randomly ass…

This study tests a new treatment called SL-28 for people with advanced solid tumors (like lung, breast, or colon cancer) that have not responded to standard therapies. SL-28 uses donated immune cells to fight cancer without genetic modification. The trial has two parts: first fin…

This study tests a newer, shorter course of radiation therapy (MH-ART) against the standard longer course (CF-IMRT) in 228 women who had surgery for cervical or endometrial cancer. The goal is to see if the newer approach causes fewer side effects and improves quality of life whi…

This study tests whether adding the targeted drug fruquintinib to standard chemotherapy works better than chemotherapy alone for people with advanced pMMR endometrial cancer. About 128 participants will receive either the combination or standard treatment. The goal is to see if t…

This study tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair-deficient (dMMR). The goal is to see if the treatment can make the cancer disappear or shrink enough so that sur…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study compares two surgical approaches for women with early-stage, high-risk endometrial cancer that has a p53 gene mutation. One group will receive the standard surgery that removes many lymph nodes, while the other group will have a less invasive sentinel lymph node biopsy…

This study compares standard immediate surgery to a 28-54 week pre-surgery plan for women with early endometrial cancer or precancerous changes and a BMI of 40 or higher. The plan includes a weight-loss drug, a hormone-releasing IUD, nutrition counseling, and exercise. The goal i…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will receive either tirzepatide or no additional treatment for 4 weeks be…

This study tests a new drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, or ovarian cancer. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants will join thi…

This study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy (a progesterone IUD) can better eliminate pre-cancer or early-stage uterine cancer in overweight women. About 30 women will be randomly assigned to get the combination or the IUD alone. T…

This study tests a new type of radiation therapy for endometrial cancer that uses MRI scans to guide the radiation beams more precisely. The goal is to reduce side effects on the bowel and bladder while still preventing cancer from coming back. About 61 women who need radiation a…

This early-phase trial tests a new drug called HH160 in about 56 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. The study is open-label, meaning every…

This study tests a drug called Inavolisib in about 48 people with advanced endometrial cancer that has a specific change in the PIK3CA gene. The goal is to see if the drug can shrink tumors or slow cancer growth. Participants will receive the drug and be monitored for response an…

This study tests a new drug called INV-8989 in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug is safe and can shrink tumors. About 178 adults with cancers like pancreatic, lung, or colorectal cancer will take…

This early study will test a new type of PET scan that uses two targets (FAPI and PSMA) at once to find and stage solid tumors like prostate, liver, ovarian, and endometrial cancers. About 20 adults with suspected or confirmed tumors will get this new scan, and doctors will compa…

This study tests a new FDA-cleared vaginal speculum designed to improve how doctors see the cervix during endometrial biopsies. It aims to make the procedure easier, more accurate, and less uncomfortable for patients. The trial will enroll 100 women who have had a previous biopsy…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can accurately detect these cancers compared to standard tests. About 300 women, some with c…

This study tests a new type of radiation therapy for endometrial cancer that uses daily MRI scans to guide treatment. The goal is to see if this approach is safe, tolerable, and reduces side effects like bowel and bladder problems. About 30 adults with endometrial cancer who need…

This study looks at whether hand and foot exercises can reduce nerve pain (like numbness and tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemothe…

This study looks at whether body composition (like muscle mass) measured from CT scans can help doctors adjust chemotherapy doses to reduce severe side effects. About 294 women with endometrial or ovarian cancer will be followed to see if using scan data leads to fewer hospital v…

This study aims to better understand how hormone levels relate to uterine cancer risk in people with abnormal uterine bleeding. About 50 participants aged 35 and older will collect daily urine samples and track their bleeding using a home monitor and a phone app. The goal is to s…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for two years. Those with a negative blood test may safely skip radiation, while others re…

This study will examine tissue samples from 50 people with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to how aggressive the cancer is and how long patients live without th…

This study compares two types of minimally invasive surgery for early-stage endometrial cancer: standard laparoscopy (small cuts in the belly) and vNOTES (surgery through the vagina with no visible scars). Researchers will check how well each method finds sentinel lymph nodes, ho…

This study aims to find how often certain inherited gene changes occur in people with endometrial cancer who already have a BRCA mutation in their tumor. Researchers will analyze blood samples from 20 participants to look for these genetic alterations. The goal is to better under…