Blood test may spare some women from radiation after endometrial cancer surgery

NCT ID NCT07339384

Not yet recruiting Knowledge-focused Sponsor: Natera, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for two years. Those with a negative blood test may safely skip radiation, while others receive standard care. The goal is to see if the blood test-guided approach works just as well as usual treatment.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER

Contacts and locations

Locations

Allegheny Health

Pittsburgh, Pennsylvania, 15224, United States
Atrium Health Levine Cancer

Charlotte, North Carolina, 28204, United States
Cleveland Clinic

Cleveland, Ohio, 44106, United States
Duke University

Durham, North Carolina, 27708, United States
New York University

New York, New York, 10016, United States
Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
University of Alabama at Birmingham Hospital

Birmingham, Alabama, 35294, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Diego

La Jolla, California, 92093, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Miami

Miami, Florida, 33146, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States

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