ENDOMETRIAL CANCER

This early-stage study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Ab…

This early-stage trial tests an experimental drug called ALTA2618 in adults with advanced solid tumors (like breast or endometrial cancer) that have a specific AKT1 E17K gene change. The main goals are to check safety and find the right dose. About 110 people who have tried other…

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that came back or spread and had limited prior treatments. The goal was to see how many patients h…

This study tests a new treatment called ADP-A2M4CD8 for people with certain cancers (like lung, ovarian, or melanoma) that have a specific protein (MAGE-A4) and a matching immune type (HLA-A2). The treatment uses the patient's own immune cells, modified to attack the cancer. The …

This early-stage trial tests a combination of two drugs (naptumomab estafenatox and durvalumab) in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find the safest dose and see if the combination can shrink tumors. About 120 …

This study tested a combination of two drugs, mirvetuximab soravtansine and pembrolizumab, in 18 people with a specific type of advanced or returning endometrial cancer that is microsatellite stable (MSS). The goal was to see if the combo could shrink tumors or stop them from gro…

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants whose cancer had returned or worsened despite prior treatment were enrolled. The goal was to see if the tumors shrank or stop…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 32 people with advanced endometrial cancer that has spread or come back and no longer responds to standard chemotherapy. The goal is to see if the combination can shrink tumors or slow cancer growth. Part…

This early-stage trial tests a new drug (AGEN1181) alone or with another drug (balstilimab) in people with advanced solid tumors that haven't responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 499 adults with …

This study tests whether the drug sacituzumab govitecan works better than standard chemotherapy for people with endometrial cancer that has come back after platinum-based chemo and immunotherapy. About 640 participants will be randomly assigned to receive either the study drug or…

This study tests a daily pill called giredestrant in 30 people with Grade 1 endometrial cancer. The goal is to see if the drug can shrink the cancer or keep it from growing over 6 months, possibly avoiding or delaying surgery. Participants take the drug for 6 months and have regu…

This early-phase study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with early-stage endometrial cancer who cannot have surgery. The goal is to see if the combination is safe and helps the immune system fight the cancer better. Ten participants wi…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, and prostate cancer. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer treatments. About 702 adults w…

This study tests the drug pembrolizumab in about 1,600 people with various advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink or control the tumors. Participants receive pembrolizumab and are monitored for tumor respons…

This study tests a combination of two drugs, abemaciclib and letrozole, in people with advanced or recurrent endometrioid endometrial cancer that cannot be cured by surgery or radiation. The main goal is to see how many participants have no cancer growth after 6 months of treatme…

This early-stage study tests an experimental pill, ATV-1601, for people with advanced solid tumors or certain breast cancers that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. About 134 ad…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer will receive the combination. The main goals ar…

This study looks at whether giving chemotherapy after surgery can help people with early-stage (stage 1 or 2) endometrial cancer who have a medium or high chance of the cancer coming back. About 244 participants who had their cancer removed and whose lymph nodes were cancer-free …

This early-phase study tests a new drug, BG-68501, in about 100 adults with advanced solid tumors (like breast, ovarian, or lung cancer) that have not responded to standard treatments. The drug targets a protein (CDK2) that helps cancer cells grow. The main goals are to check saf…

This study tests a drug called ceralasertib, alone or with other medicines (olaparib or durvalumab), in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors or slow their growth. Ab…

This early-phase study tests a new drug called IMGN151 in adults with gynaecological cancers that have come back after standard treatments. The drug is designed to target a protein on cancer cells and deliver a chemotherapy-like payload directly. The main goals are to find a safe…

This study tests a special device that combines a vaginal dilator with a drug delivery tube to help prevent vaginal narrowing and scarring after pelvic radiation therapy. About 76 women aged 18-70 who have completed radiation for pelvic tumors will use the device regularly. The g…

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy for people with a specific type of advanced or recurrent endometrial cancer (MMR deficient). About 260 participants will be randomly assigned to receive either dostarlimab or chemo…

This study is testing a new robotic surgery system (Medtronic Hugo™) for hysterectomy, a surgery to remove the uterus. It includes 70 adult patients with conditions like uterine fibroids, endometriosis, or gynecologic cancers. The goal is to see if the robot can safely perform th…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This study tests a drug called retifanlimab, given alone or with other therapies, in people with advanced or metastatic endometrial cancer that worsened after platinum chemotherapy. The goal is to see if the drug can shrink tumors or slow the disease. About 206 adults are taking …

This study tests whether the drug selinexor can help keep advanced or recurrent endometrial cancer from growing back after initial chemotherapy. About 276 adults whose cancer has a normal p53 gene and who responded to platinum-based chemo will receive either selinexor or a placeb…

This study tests a new treatment plan for people with high-risk endometrial cancer who have already had surgery to remove the uterus. The plan combines an immunotherapy drug (pembrolizumab) with radiation to the vagina, followed by more immunotherapy plus chemotherapy. The goal i…

This study tests two drugs, atezolizumab and bevacizumab, given together to women with advanced, recurrent, or persistent endometrial cancer. The goal is to see if the combination can shrink tumors or slow cancer growth. About 110 women who have already tried at least one chemoth…

This study tests whether giving the immunotherapy drug pembrolizumab before standard surgery can shrink tumors in people with a specific type of uterine cancer (MMRd). Twelve participants will receive 9 cycles of pembrolizumab before their hysterectomy. The goal is to see how man…

This early-phase study tests a new drug called AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) in a single shot. It enrolls 18 adults with various advanced solid tumors that have spread or come back. The main goal is to find the safest dose and underst…

This study tests a new drug, MK-2870, against standard chemotherapy in about 710 people with endometrial cancer that has worsened after platinum chemo and immunotherapy. The goal is to see if MK-2870 helps people live longer and delays cancer growth. Participants are randomly ass…

This study looks at four different tools to help people who have had cancer improve their diet, physical activity, and weight. About 353 cancer survivors will use these tools to see if they can adopt healthier habits that may lower the chance of their cancer coming back. The stud…

This study tests a new way to see if cancer has spread to lymph nodes in women with early-stage cervical or endometrial cancer. Before surgery, a radioactive sugar is injected into the cervix and a PET scan shows which lymph nodes contain cancer. The goal is to improve surgical p…

This study tests a newer type of radiation therapy called online adaptive radiotherapy (oART) for people who have had surgery for endometrial or cervical cancer. The goal is to see if using smaller treatment margins can reduce side effects while still effectively targeting any re…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer before they have surgery. Nineteen participants were enrolled to see if…

This study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will do exercises like chair stands and arm curls, guided by phone or video coaching. The goal is to see …

This study tests a program called Journey Ahead that helps women with gynecologic cancers improve their coping and communication skills. About 30 participants will learn strategies to manage emotional distress and talk with loved ones and doctors. The goal is to reduce depressive…

This study looks at whether what women eat in the month before starting chemotherapy is linked to levels of a protein called hepcidin, and whether that affects how much chemo they can actually receive. Researchers will follow 100 women with breast or gynecological cancer who have…

This study aimed to see if a special PET/MRI scan could predict whether hormone therapy with a hormone-releasing IUD would work for women with complex atypical hyperplasia or early-stage endometrial cancer. The plan was to enroll 8 women and follow them for 6 months. However, the…

This study looks at ways to help people who have genetic test results for inherited cancer risks. The goal is to see if certain interventions can help them follow cancer prevention guidelines and share their results with family members. The study includes 720 adults with specific…

This study looks at how women's quality of life and sexuality are affected after a very rare and extensive surgery called pelvic exenteration, used for gynecologic cancers that have come back. Researchers will ask about 21 patients to fill out questionnaires about their physical,…

This study collects information from about 300 endometrial cancer patients treated across Asia between 2021 and 2023. Researchers want to see how different cancer cell features affect treatment choices, such as radiation or chemotherapy. The goal is to learn how to tailor treatme…

This study looks at how diet, lifestyle, and genetics influence the risk of developing endometrial cancer. Researchers will compare women who have or had the cancer with those who don't, to identify key risk factors. About 1,315 women from New Jersey are taking part.

This study was designed to test a mobile health app that helps patients with recurrent head and neck or gynecologic cancers track their symptoms, treatment side effects, and quality of life. The goal was to see if patients find the app easy to use and useful. However, the study w…

This study looks at whether group support or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to one of three groups: group support, one-on-one peer support, or enhanced usual care. The…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study gathers fresh tumor samples from 416 people with various advanced cancers to develop a lab test that predicts whether immunotherapy will work. Participants provide tissue and health data, but receive no experimental treatment. The goal is to train a diagnostic platform…

This study looks at whether a personalized surgical approach for endometrial cancer can be just as effective as standard full lymph node removal. During surgery, doctors examine the tumor tissue to decide how many lymph nodes to take out. The goal is to reduce surgery time and si…