Engineered immune cells take on multiple Hard-to-Treat cancers
NCT ID NCT04044859
First seen Feb 13, 2026 · Last updated May 01, 2026 · Updated 5 times
Summary
This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is given alone or with standard immunotherapy drugs. The main goals are to check safety and find the right dose, while also seeing if tumors shrink.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Clinica Universitaria de Navarra
Pío, Pamplona, 31008, Spain
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Duke University Medical Center, Duke Cancer Institute
Durham, North Carolina, 27710, United States
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Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Hospital Clinico de Valencia
Ibanez, Valencia, 46010, Spain
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Hospital Universitario 12 De Octubre
Madrid, Avenida de Cordoba S/n, 28041, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario HM Sanchinarro CIOCC
Madrid, 28050, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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M.D. Anderson Cancer Center
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Name of Institution: Orlando Health Cancer Institute
Orlando, Florida, 32806, United States
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OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Washington University - School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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