New drug combo tested for hard-to-treat cancers
NCT ID NCT04344795
First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 38 times
Summary
This early-phase trial tested a new drug called TPST-1495, given alone or with pembrolizumab, in 89 people with advanced solid tumors (like colorectal, lung, or head and neck cancers) that had stopped responding to standard treatments. The main goal was to find a safe dose and check for side effects. Researchers also looked for signs that the drug might shrink tumors or slow their growth.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baystate Gynecologic Oncology
Springfield, Massachusetts, 01107, United States
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Carolina BioOncology Institute
Huntersville, North Carolina, 28078, United States
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SCRI-OK Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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START Midwest
Grand Rapids, Michigan, 49546, United States
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Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine
Baltimore, Maryland, 21287, United States
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South Texas Accelerated Research Therapeutics (START)
San Antonio, Texas, 78229, United States
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Tennessee Oncology
Nashville, Tennessee, 37203, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
Conditions
Explore the condition pages connected to this study.