New drug XMT-1660 enters first human tests for Hard-to-Treat cancers
NCT ID NCT05377996
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This early-phase study tests a new drug called XMT-1660 in about 319 people with advanced solid tumors, including breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. Researchers will also see if the drug shrinks tumors. This is a first-in-human trial, so the main focus is safety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Avera Cancer Institute
RECRUITINGSioux Falls, South Dakota, 57105, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Comprehensive Cancer Centers of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Florida Cancer Specialists
RECRUITINGSarasota, Florida, 34232, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 09109, United States
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Henry Ford Health Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112, United States
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ICHAN School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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MD Anderson
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic - Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic - Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Mayo Clinic Comprehensive Cancer Center
RECRUITINGPhoenix, Arizona, 85054, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NEXT Oncology Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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New York University Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Sarah Cannon Research Institute (SCRI)
RECRUITINGNashville, Tennessee, 37203, United States
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Stephenson Cancer Center Oklahoma University Health
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Summit Cancer Centers
RECRUITINGSpokane, Washington, 99208, United States
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Texas Oncology, P.A.
RECRUITINGDallas, Texas, 75251, United States
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UC Irvine Health-Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
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UCLA David Geffen School of Medicine, Division of Hematology/Oncology
RECRUITINGSanta Monica, California, 90404, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
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Winship Cancer Institute, Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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