New antibody drug targets HER2 cancers in broad trial

NCT ID NCT06695845

Recruiting now Disease control Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This phase 2 trial tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers, including breast, lung, stomach, and others. Participants have already tried at least one standard treatment. The study measures how many tumors shrink or disappear. Zanidatamab is given by IV and aims to control the disease rather than cure it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zanidatamab (also called ZW25, JZP598, ZIIHERA®) - an antibody given by IV infusion
What this could lead to: If successful, this could provide a new treatment option for people with several types of HER2-positive cancers that have stopped responding to other therapies.
What could go wrong: This is a mid-stage trial with no control group, so results are preliminary. It may not work for all cancer types tested, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm colorectal cancer colorectal neoplasm endometrial cancer endometrium neoplasm esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm gastroesophageal cancer malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic neoplasm salivary gland cancer transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER COLORECTAL CANCER ENDOMETRIAL CANCER ESOPHAGEAL CANCER GASTRIC CANCER GASTROESOPHAGEAL CANCER HER-2 PROTEIN OVEREXPRESSION NON-SMALL CELL LUNG CANCER OVARIAN CANCER PANCREATIC CANCER SALIVARY GLAND CANCER UROTHELIAL CARCINOMA

Contacts and locations

Locations

Affiliated Oncologists
WITHDRAWN

Chicago Ridge, Illinois, 60415, United States
Alliance Cancer Specialists
WITHDRAWN

Horsham, Pennsylvania, 19044, United States
Arizona Oncology Associates, PC - NAHOA
WITHDRAWN

Prescott, Arizona, 86301, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Barbara Ann Karmanos Cancer Institute
WITHDRAWN

Detroit, Michigan, 48201, United States
Blue Ridge Cancer Care
WITHDRAWN

Roanoke, Virginia, 24014, United States
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun-Eup, Hwasun-Gun, 58115, South Korea
Florida Cancer Specialists - East
WITHDRAWN

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists - Lake Nona
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32827, United States
Florida Cancer Specialists - North
WITHDRAWN

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists - South
WITHDRAWN

Fort Myers, Florida, 33901, United States
Hospital Regional Universitario de Malaga - Hospital General
RECRUITING

Málaga, 29010, Spain
Korea University Guro Hospital
RECRUITING

Guro-gu, Seoul, 04524, South Korea
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
National Cancer Center Suwon
RECRUITING

Suwon, Gyeonggi-do, 10408, South Korea
Rocky Mountain Cancer Center
RECRUITING

Littleton, Colorado, 80120, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Samsung Medical Center
RECRUITING

Gangnam-gu, Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seoul, 13620, South Korea
Seoul National University Hospital
RECRUITING

Jongno-gu, Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seodaemun-gu, Seoul, 03722, South Korea
Tennessee Cancer Specialists
WITHDRAWN

Knoxville, Tennessee, 37909, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - San Antonio
WITHDRAWN

San Antonio, Texas, 78217, United States
Texas Oncology - West Texas
WITHDRAWN

Amarillo, Texas, 79124, United States
The Catholic University of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, 04524, South Korea
The Catholic University of Korea St Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 10408, South Korea

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