New drug combo shows promise for Tough-to-Treat endometrial cancer
NCT ID NCT06463028
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new combination of drugs (sapanisertib and serabelisib, together called PIKTOR) plus standard chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. The goal is to see if this combo can shrink tumors or slow the cancer. A small part of the study also looks at whether a special low-insulin diet can help the drugs work better. About 40 adults will take part.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alliance Cancer Specialists, PC
RECRUITINGDoylestown, Pennsylvania, 18901, United States
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Avera Cancer Institute
RECRUITINGSioux Falls, South Dakota, 57105, United States
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Florida Cancer Specialists, East
RECRUITINGWest Palm Beach, Florida, 33401, United States
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Florida Cancer Specialists, North
RECRUITINGSt. Petersburg, Florida, 33705, United States
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Maryland Oncology Hematology, P.A.
RECRUITINGBrandywine, Maryland, 20613, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Minnesota Oncology Hematology, P.A.
RECRUITINGMaple Grove, Minnesota, 55369, United States
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Mount Sinai Comprehensive Cancer Center
RECRUITINGMiami Beach, Florida, 33140, United States
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Northwest Cancer Specialists, P.C.
RECRUITINGPortland, Oregon, 97227, United States
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Oncology Associates of Oregon, P.C.
RECRUITINGEugene, Oregon, 97401, United States
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Texas Oncology - Gulf Coast
RECRUITINGThe Woodlands, Texas, 77380, United States
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Texas Oncology - West Texas
RECRUITINGEl Paso, Texas, 79902, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92037, United States
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University of California, San Francisco (UCSF)
RECRUITINGSan Francisco, California, 94158, United States
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 46214, United States
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Virginia Cancer Specialists, P.C.
RECRUITINGFairfax, Virginia, 22031, United States
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West Penn Hospital
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Women's Cancer Care Associates, LLC
RECRUITINGAlbany, New York, 12208, United States