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New drug combo shows promise for Tough-to-Treat endometrial cancer

NCT ID NCT06463028

Recruiting now Disease control Sponsor: Faeth Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new combination of drugs (sapanisertib and serabelisib, together called PIKTOR) plus standard chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. The goal is to see if this combo can shrink tumors or slow the cancer. A small part of the study also looks at whether a special low-insulin diet can help the drugs work better. About 40 adults will take part.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Endometrioid endometrial cancer endometrial endometrioid adenocarcinoma endometrium neoplasm Genital Diseases hereditary sensory and autonomic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Alliance Cancer Specialists, PC

    RECRUITING

    Doylestown, Pennsylvania, 18901, United States

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

  • Florida Cancer Specialists, East

    RECRUITING

    West Palm Beach, Florida, 33401, United States

  • Florida Cancer Specialists, North

    RECRUITING

    St. Petersburg, Florida, 33705, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Brandywine, Maryland, 20613, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Minnesota Oncology Hematology, P.A.

    RECRUITING

    Maple Grove, Minnesota, 55369, United States

  • Mount Sinai Comprehensive Cancer Center

    RECRUITING

    Miami Beach, Florida, 33140, United States

  • Northwest Cancer Specialists, P.C.

    RECRUITING

    Portland, Oregon, 97227, United States

  • Oncology Associates of Oregon, P.C.

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Texas Oncology - Gulf Coast

    RECRUITING

    The Woodlands, Texas, 77380, United States

  • Texas Oncology - West Texas

    RECRUITING

    El Paso, Texas, 79902, United States

  • UC San Diego Moores Cancer Center

    RECRUITING

    La Jolla, California, 92037, United States

  • University of California, San Francisco (UCSF)

    RECRUITING

    San Francisco, California, 94158, United States

  • University of Cincinnati Medical Center

    RECRUITING

    Cincinnati, Ohio, 46214, United States

  • Virginia Cancer Specialists, P.C.

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • West Penn Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Women's Cancer Care Associates, LLC

    RECRUITING

    Albany, New York, 12208, United States

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