Targeted drug cocktail aims to shrink Hard-to-Treat uterine cancers

NCT ID NCT06518564

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times

Summary

This study tests whether combining two drugs—avelumab (an immunotherapy) and M1774 (a targeted pill)—can shrink or slow the growth of recurrent endometrial cancer in people whose tumors have a specific genetic change (ARID1A mutation). About 25 participants will receive the combination and be monitored for tumor response and side effects. The goal is to find a new treatment option for this hard-to-treat cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.