ENDOMETRIAL CANCER

This study tests whether daily online adaptive radiotherapy (ART) can safely deliver fewer, stronger radiation doses for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to either standard radiation or the new adaptive approach…

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after previous treatments, including immunotherapy. The goal is to see if the drug can shrink tumors and how safe it is. Participants receive treatmen…

This early-phase study tests an experimental drug called CGT6297 in 90 adults whose advanced solid tumors (including certain breast and endometrial cancers) have a specific genetic change called PIK3CA. The main goals are to check the drug's safety and find the best dose, while a…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study tests a new type of radiation therapy for women with endometrial cancer who need radiation after surgery. The treatment uses MRI scans to guide the radiation beam more precisely, which may reduce side effects like stomach or bladder problems. About 61 participants will…

This study looks at a program to help women with severe obesity (BMI 40 or higher) and early-stage endometrial cancer get healthier before surgery. The program includes weight-loss medication, a hormone-releasing IUD, diet changes, and exercise. The goal is to see if this approac…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair deficient. The goal is to see if the drugs can make the cancer disappear or shrink enough to avoid surgery. Participants will rec…

This study tests whether tirzepatide, a diabetes and weight-loss drug, can slow or stop the growth of early endometrial cancer or its precursor (EIN) in women with obesity. About 40 women will be randomly assigned to receive tirzepatide or no drug for 4 weeks before their schedul…

This study tests a drug called Inavolisib in about 48 women with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if the drug can shrink tumors or slow cancer growth. Participants must have tried other treatments first and have …

This study tests a new drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, ovarian, or endometrial cancer. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants will receive …

This study tests whether adding the drug fruquintinib to standard chemotherapy helps people with advanced endometrial cancer that has a normal repair system (pMMR). About 128 adults aged 18-75 will be randomly assigned to get either the combo or chemo alone. The goal is to see if…

This study compares two surgical approaches for people with early-stage, high-risk endometrial cancer that has a p53 mutation. One group will have a standard surgery that removes many lymph nodes, while the other will have a less invasive procedure that only removes a few key lym…

This study tests a new FDA-cleared vaginal speculum designed to make endometrial biopsies more comfortable and accurate. About 100 women who have had this biopsy before will try the new device. Doctors will rate how well they can see the cervix, how easy the tool is to use, and w…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancer. The goal is to see if this less invasive method can detect cancer-related markers as well as or better than current tests. About 300 women, s…

This study looks at whether hand and foot exercises can reduce nerve pain (like numbness and tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve their quality o…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health and find the right follow-up care. The goal is to see if this program improves how confident and capable survi…

This study aims to find how often people with endometrial cancer have inherited changes in certain genes, including BRCA. Researchers will analyze blood samples from 20 participants who already have a tumor with a BRCA mutation. The goal is to better understand the genetic roots …

This study examines tissue samples from 50 women with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to tumor features and patient survival. The goal is to better understand w…

This observational study looks at 350 women with early-stage endometrial cancer to see if current risk assessment methods can identify who truly needs lymph node staging. Participants receive standard care and are followed for 3 years. The goal is to refine treatment guidelines a…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 participants will be followed for two years. Those with a negative blood test may safely skip radiation, while ot…