ENDOMETRIAL CANCER

This study compares two surgical approaches for treating high-risk endometrial cancer. Researchers want to see if a less invasive method that maps and removes only key lymph nodes works as well as the current standard of removing many lymph nodes. The goal is to reduce surgery co…

This early-stage study is testing a new targeted drug called CGT6297 in adults with advanced solid tumors that have a specific genetic change called a PIK3CA mutation. The main goals are to find a safe dose and see if the drug shows early signs of helping to shrink tumors. The st…

This study is testing whether the drug enfortumab vedotin can help control advanced endometrial (uterine) cancer that has worsened despite previous treatments. Up to 12 patients whose cancer has progressed after chemotherapy and immunotherapy will receive the drug for up to one y…

This study is testing an experimental drug called QLS5132, given by IV in combination with other cancer therapies, for people with advanced solid tumors like lung, stomach, ovarian, and endometrial cancer. The main goals are to find a safe and effective dose and to see how well t…

This study is observing a pre-surgery program designed for obese women with early-stage endometrial cancer or pre-cancer. The program combines weight-loss medication, a hormone-releasing device, diet, and exercise. Researchers want to see if this approach improves patients' overa…

This study is testing whether injecting a lab-made collagen directly into the uterus, along with standard hormone pills, can better treat early-stage endometrial cancer or precancerous changes in women who want to preserve their fertility. Researchers will compare the collagen-pl…

This early study is testing whether the weight-loss medication tirzepatide can slow the growth of endometrial cancer tumors. Twenty obese women with this type of cancer will take the drug for four weeks before their scheduled surgery. Researchers will compare tumor samples taken …

This study is testing whether a combination of two immunotherapy drugs can shrink tumors enough to avoid surgery in women with a specific, surgically removable type of endometrial cancer. It will enroll about 30 women who have not had recent cancer treatment. The main goal is to …

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This is the first study in humans testing an experimental drug called CTX-10726 for several advanced cancers that have stopped responding to standard treatments. Researchers will give increasing doses to 70 patients to check safety, determine the best dose, and see if the drug sh…

This study is creating and testing a patient navigation program to help young adults who have survived cancer. The program aims to guide survivors to get the recommended primary care and cancer check-ups they need. Researchers will first adapt an existing program for young surviv…

This study is testing whether adding a new drug called fruquintinib to standard chemotherapy works better than chemotherapy alone for advanced endometrial cancer that has not spread to other organs. It will involve 128 women with this specific type of cancer who have not had prio…

This study tests whether a new care coordination program helps cancer patients better manage chronic conditions like high blood pressure, diabetes, and high cholesterol during cancer treatment. Researchers will compare patients who receive the new program to those getting usual c…

This study is testing if a medication called tirzepatide, which is used for weight loss and diabetes, can slow the growth of abnormal cells in the uterus before a patient's scheduled surgery. It will involve 40 women with obesity who have been diagnosed with a pre-cancerous condi…

This study is testing a new, more comfortable vaginal swab device to see if it can detect early signs of ovarian and endometrial cancer. Researchers will collect samples from 300 women attending gynecology clinics, including some with cancer and some without, to look for biologic…

This study is testing whether a simple hand and foot exercise program can help reduce nerve pain and improve quality of life for older women receiving chemotherapy for gynecologic cancers. Researchers will enroll 74 participants aged 65+ who are experiencing nerve pain from their…

This study is testing a newly designed vaginal speculum to see if it makes endometrial biopsies more comfortable for patients and easier for doctors. It will involve 100 women who need follow-up biopsies for endometrial cancer. Doctors will use the new tool during the procedure a…

This study is testing whether a blood test that looks for tiny pieces of cancer DNA can help doctors decide which patients need extra radiation treatment after surgery. It will compare outcomes for women who are monitored with the blood test against those who receive standard rad…

This study aims to understand if the amount of a specific protein (METTL-14) found in endometrial cancer tissue is connected to how the disease behaves and how patients fare over time. Researchers will analyze tissue samples from 50 patients who have already been treated for a co…

This study aims to understand how often people with endometrial cancer have inherited changes in specific genes. Researchers will analyze blood samples from 20 participants who already have a specific tumor gene change. The goal is to gather knowledge that could help guide future…

This study aims to gather real-world data to better identify which patients with early-stage endometrial cancer truly need lymph node surgery. It will follow 350 women receiving standard care to see if some can safely avoid this procedure without affecting their treatment plan. T…