ENDOMETRIAL CANCER

This early-stage study is testing a new oral drug, GSK4418959, for adults with advanced solid tumors that have specific genetic features (called dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes the drug, and check if it can shrink tumors, either …

This early-stage study is testing a new drug called IMGN151 in patients with recurrent gynecologic cancers that have returned after previous treatments. The main goals are to determine the safest dose, understand how the drug behaves in the body, and see if it shows any early sig…

This study is testing whether a new combination of two drugs, cadonilimab and lenvatinib, can help control advanced endometrial cancer that has continued to grow after standard chemotherapy. It will involve about 32 patients to see how well the combination shrinks tumors and how …

This study is testing an immunotherapy drug called retifanlimab, given alone or with other drugs, for women with advanced endometrial (uterine) cancer that has continued to grow despite standard platinum-based chemotherapy. The main goal is to see if the treatment can shrink tumo…

This study is testing whether adding a new immunotherapy drug (TSR-042) to standard radiation treatment is safe and effective for people with endometrial (uterine) cancer who cannot have surgery. It will involve about 10 participants to first check for side effects. The goal is t…

This study tested an immunotherapy drug called pembrolizumab in people with many different types of advanced solid tumors that had stopped responding to standard treatments. The main goal was to see if the drug could shrink tumors and to identify biological markers that might pre…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This early-stage trial is testing the safety of a new treatment called ADP-A2M4CD8, which uses a patient's own modified immune cells to fight cancer. The study will enroll 120 adults with one of nine advanced cancers who have specific genetic markers. Researchers will give the ce…

This large, late-stage study is testing whether a newer targeted drug called sacituzumab govitecan works better than standard chemotherapy options for people with advanced endometrial (uterine) cancer. It is for patients whose cancer has grown or returned after receiving platinum…

This study is testing whether different types of social support can help Black women complete their prescribed endometrial cancer treatments and feel less alone. Researchers are comparing weekly group meetings, one-on-one peer support, and standard care to see which works best. T…

This large, late-stage trial is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy works better than chemotherapy alone for women with advanced or recurrent endometrial cancer that has a specific genetic marker (MMR deficient). The main goal is to …

This study is testing a new treatment plan for people with a high risk of their endometrial (uterine) cancer coming back after surgery. It combines a short course of targeted radiation with an immunotherapy drug (pembrolizumab) and then adds chemotherapy. The main goal is to see …

This study is testing an experimental drug called MK-2870 (sacituzumab tirumotecan) for people with advanced endometrial cancer that has returned or progressed after standard platinum-based chemotherapy and immunotherapy. It will compare MK-2870 to standard chemotherapy chosen by…

This study is testing whether combining an experimental drug (DKN-01) with an approved immunotherapy (pembrolizumab) can help control advanced or recurrent endometrial cancer. It will involve about 8 women with specific types of this cancer to see if the treatment is effective an…

This study tested whether combining two drugs, letrozole and everolimus, could help control advanced or returning endometrial cancer. It involved 42 patients whose cancer had progressed or returned after prior treatments. Researchers monitored if tumors shrank or stopped growing …

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is testing an oral medication called giredestrant in 30 patients with early-stage, low-grade endometrial cancer. The main goal is to see if the drug can shrink or eliminate the cancer cells in the uterus after six months of treatment. Researchers will monitor how well …

This study is testing whether a combination of two immunotherapy drugs can help control advanced endometrial cancer that has returned or spread. The trial will involve 110 women whose cancer has progressed despite previous chemotherapy. Researchers will measure whether tumors shr…

This study is testing whether doctors can tailor surgery for endometrial (uterine) cancer based on quick tissue analysis during the operation. The goal is to reduce unnecessary lymph node removal and its risks for low-risk patients while still fully treating high-risk patients. R…

This study is testing whether a combination of two existing drugs, abemaciclib and letrozole, can stop advanced or recurrent endometrial cancer from getting worse for at least six months. It involves about 53 women whose cancer has spread or returned and is not likely curable by …

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This study is testing whether a combination of three existing drugs can help control advanced or returning endometrial (uterine) cancer. The drugs—everolimus, letrozole, and metformin—work in different ways to potentially slow or stop cancer growth. The trial will enroll 62 patie…

This study is testing whether injecting a small amount of radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can create a clearer picture of which lymph nodes contain cancer. Researchers want to see if this method helps surgeons better identify and remove cancerous …

This study is testing whether a 10-week home exercise program can improve fitness and quality of life for women who have finished treatment for endometrial cancer. Researchers will measure changes in strength, endurance, and daily activity levels in 10 participants. The goal is t…

This study is testing an online program called 'Journey Ahead' designed to help women with gynecologic cancers (like ovarian, cervical, or uterine cancer) develop better coping and communication skills. The program aims to reduce distress, improve emotional acceptance, and enhanc…

This study is a data collection project to understand how doctors in Asia use detailed genetic and molecular tests to choose follow-up treatments (like radiation or chemotherapy) for patients with endometrial cancer. It will analyze the medical records of about 300 patients treat…

This study aimed to test a smartphone app for patients with recurrent head, neck, or gynecologic cancers. The goal was to see if the app was easy to use and helpful for patients to report their daily symptoms, quality of life, and any barriers to their care during treatment. The …

This study is testing whether a very low-carbohydrate (ketogenic) diet is safe and tolerable for overweight or obese patients newly diagnosed with endometrial (uterine) cancer before they have surgery. Researchers want to see if patients can stick to the diet and what effects it …

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study aimed to see if a special imaging scan (FFNP PET/MRI) could predict whether a hormone-releasing IUD would successfully treat early endometrial cancer or a precancerous condition. It planned to enroll 8 women who were scheduled to receive this IUD treatment. The goal wa…

This study is testing different online tools to help people who have inherited a gene change that increases cancer risk. It aims to help them better share this important information with their family members and follow the recommended cancer screening and prevention guidelines. T…

This study is observing 100 women with breast or gynecological cancers to see if their diet in the month before starting chemotherapy is linked to levels of a blood protein called hepcidin. Researchers will then check if hepcidin levels are connected to how well patients can stic…