ENDOMETRIAL CANCER

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that had come back or spread and had limited prior treatments. The goal was to see how many patien…

This phase 3 trial tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy for women with advanced or recurrent endometrial cancer that has a specific genetic feature (MMR deficient). About 260 participants will be randomly assigned to receive eit…

This study tests a combination of two drugs, atezolizumab and bevacizumab, in 110 women with advanced, recurrent, or persistent endometrial cancer that has not responded to standard treatments. The goal is to see if this drug pair can shrink tumors or slow cancer growth. Particip…

This study looks at whether giving chemotherapy after surgery can help people with early-stage (stage I-II) endometrial cancer who have a medium or high chance of the cancer coming back. About 244 participants who had their cancer removed and no cancer found in their lymph nodes …

This early-phase study tests a new drug called IMGN151 in 256 adults with recurrent gynaecological cancers (ovarian, endometrial, cervical, and related cancers). The drug is designed to target and kill cancer cells while sparing healthy ones. The main goals are to check safety, f…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors (like ovarian, breast, prostate, and lung cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and tolerable when given alon…

This study tests a drug called retifanlimab, given alone or with other treatments, for people with advanced or metastatic endometrial cancer that got worse after platinum chemotherapy. The goal is to see if the drug can shrink tumors or slow the cancer. About 206 adults are takin…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 32 people with advanced endometrial cancer that has spread or returned and is no longer responding to standard chemotherapy. The goal is to see if this treatment can shrink tumors or slow the disease. Par…

This study tests a drug called ceralasertib, either alone or combined with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, endometrial, and prostate cancers. The goal is to see if these combinations can shrink tumors or slow their gr…

This study tests a drug called sacituzumab govitecan against standard chemotherapy in 640 people with endometrial cancer that has returned or persisted after platinum-based chemo and immunotherapy. The goal is to see if the new drug can slow cancer growth or extend survival. Part…

This study tested whether combining two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer that has come back or spread. About 42 participants took part. The goal was to see if the combination could shrink tumors or stop them from growing, …

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This study tests a new drug called MK-2870 against standard chemotherapy for people with endometrial cancer who have already tried platinum-based chemo and immunotherapy. About 710 participants will receive either MK-2870 or a doctor-chosen chemo. The goal is to see if MK-2870 he…

This study tests whether adding the immunotherapy drug pembrolizumab to standard radiation and chemotherapy can help control high-risk endometrial cancer after surgery. About 45 participants who have had a hysterectomy will receive radiation to the vagina, followed by three cycle…

This early-phase study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with early-stage endometrial cancer who cannot have surgery. The goal is to see if the combination is safe and can help the immune system attack the cancer more effectively. Ten p…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer are taking part. The main goal is to check safe…

This study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H). The drug aims to shrink tumors by blocking a DNA repair protein. The trial will check safety, side effects, and how well the drug work…

This early-phase study tests two experimental immunotherapy drugs (botensilimab and balstilimab) in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the best dose. About 499 participants with various can…

This study tests a daily pill called giredestrant in 30 people with Grade 1 endometrial cancer (a low-grade uterine cancer). The goal is to see if the drug can shrink or stop the cancer from growing over 6 months, possibly avoiding or delaying surgery. Participants take the drug …

This early-phase study tests a new drug, AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment for people with advanced solid tumors that have stopped responding to standard therapies. The main goal is to find the safest dose and check for…

This study tests two drugs, abemaciclib and letrozole, in 53 people with advanced or returning endometrioid endometrial cancer that cannot be cured by surgery or radiation. The goal is to see how many patients have no cancer growth after 6 months. Treatment continues until side e…

This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is give…

This early-phase trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in adults with advanced solid tumors that have not responded to standard treatments. The main goal is to find a safe dose and check for side effects. About 120 people with various canc…

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can better show which pelvic lymph nodes contain cancer in women with stage IB1 cervical cancer or high-grade endometrial cancer. About 42 women scheduled for surgery…

This study tests whether group or one-on-one peer support helps Black patients finish their endometrial cancer treatment and feel less alone. About 252 participants will be randomly assigned to group support, a peer buddy, or standard care. The goal is to see if social support im…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will follow a guided exercise plan and be tested on strength, balance, and endurance. The goal is to see …

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants will follow the diet before their scheduled surg…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This study looks at ways to help people who have inherited gene changes that raise cancer risk. It tests if certain tools can help them follow doctor guidelines for managing their cancer risk and share their genetic results with family members. About 720 adults with these gene ch…

This study looks at how diet, lifestyle, and genetics influence the risk of getting endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey…

This study looks at 100 women with breast or gynecological cancer to see if their diet before starting chemotherapy affects levels of a protein called hepcidin. Researchers want to know if hepcidin levels are linked to how much of the planned chemotherapy dose patients actually r…

This study aimed to see if a special PET/MRI scan (FFNP) could predict how well a hormone-releasing IUD works for women with complex atypical hyperplasia (a precancerous condition) or grade 1 endometrial cancer. The plan was to enroll 8 women and follow them for 6 months. However…

This study was designed to see if a mobile health app helps patients with recurrent head and neck or gynecologic cancers track their symptoms and quality of life. Researchers planned to ask patients about their experience using the app and whether they found it easy and useful. T…

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…

This study tests whether a personalized surgical approach for endometrial cancer can safely reduce the extent of lymph node removal. Doctors use a real-time tissue analysis during surgery to decide how much lymph node dissection is needed. The goal is to lower surgical risks and …

This study collects information from about 300 endometrial cancer patients treated across Asia between 2021 and 2023. Researchers want to see how different cancer cell features affect treatment choices, such as radiation or chemotherapy. The goal is to help doctors give the right…